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001480860 019__ $$a1396974982
001480860 020__ $$a9789819923021$$q(electronic bk.)
001480860 020__ $$a9819923026$$q(electronic bk.)
001480860 020__ $$z9819923018
001480860 020__ $$z9789819923014
001480860 0247_ $$a10.1007/978-981-99-2302-1$$2doi
001480860 035__ $$aSP(OCoLC)1397572402
001480860 040__ $$aEBLCP$$beng$$cEBLCP$$dYDX$$dGW5XE$$dOCLCO
001480860 049__ $$aISEA
001480860 050_4 $$aRS192
001480860 08204 $$a615.1072$$223/eng/20230927
001480860 24500 $$aRecent advances in pharmaceutical innovation and research /$$cPrati Pal Singh, editor.
001480860 260__ $$aSingapore :$$bSpringer,$$c2023.
001480860 300__ $$a1 online resource (774 p.)
001480860 500__ $$a4.4.2 The Architecture of Fuzzy Logic
001480860 5050_ $$aIntro -- Foreword -- Preface -- Contents -- Editor and Contributors -- Part I: Pharmaceutical Innovation and Research -- 1: Innovation in Stabilization of Biopharmaceuticals -- 1.1 Introduction -- 1.2 Stability Is the Major Concern for Biopharmaceuticals -- 1.3 Mechanisms of Protein Degradation -- 1.3.1 Self-Assembly of Monomeric Protein -- 1.3.2 Aggregation of Conformationally Altered Monomers -- 1.3.3 Aggregation of Chemically Modified Monomer -- 1.3.4 Nucleation-Mediated Aggregation -- 1.3.5 Surface-Induced Aggregation -- 1.4 Instability of Protein Drugs -- 1.4.1 Denaturation
001480860 5058_ $$a1.4.2 Aggregation -- 1.4.3 Precipitation -- 1.4.4 Chemical Instability -- 1.5 Novel Stabilizers -- 1.5.1 Immobilization of Enzymes -- 1.5.2 Aptamers -- 1.6 Outlook -- References -- 2: Concepts in Pharmacogenomics: Tools and Applications -- 2.1 Background -- 2.2 Pharmacogenomics Concept -- 2.3 History -- 2.4 Inter-individual Differences in Therapeutic Response to Drugs -- 2.5 Methods Used in Pharmacogenomics Research -- 2.6 OMICS Tools Used in Pharmacogenomics Research -- 2.6.1 Transcriptomics -- 2.6.2 Pharmacometabolomics -- 2.6.3 Proteomics -- 2.6.4 Genomics -- 2.7 Applications
001480860 5058_ $$a2.7.1 Precision Medicine -- 2.7.2 Drug Discovery and Development -- References -- 3: Pharmacogenetics: A New Approach for the Selection of the Right Drug -- 3.1 Introduction -- 3.2 History of Pharmacogenomics -- 3.2.1 In the Early 1930s -- 3.2.2 In the Late 1930s -- 3.2.3 In the Period of the 1960s -- 3.2.4 The Present Scenario -- 3.3 Role of Pharmacogenomics in Pharmacokinetics and Pharmacodynamics -- 3.3.1 Pharmacokinetic Interactions -- 3.3.2 Pharmacodynamic Interaction -- 3.4 Investigation of Pharmacogenome -- 3.4.1 First-Generation Sequencers of DNA
001480860 5058_ $$a3.4.2 The Beginning of High Throughput-Next-Generation Sequencing (HT-NGS) -- 3.4.3 HT-NGS Platforms of the Second Generation -- 3.4.4 HT-NGS Platforms of the Third Generation -- 3.4.5 Sequencer for Single Molecules in Real-Time (SMRTTM) -- 3.4.6 HeliScopeTM -- 3.4.7 RNA Polymerase (RNAP) Sequencer -- 3.4.8 DNA Sequencer Using Nanopores -- 3.4.9 VisiGen Biotechnologies -- 3.4.10 Technology for Multiplex Polony -- 3.5 Clinical Application of Pharmacogenomics -- 3.5.1 Proton Pump Inhibitors (PPIs) -- 3.5.2 Codeine -- 3.5.3 Carbamazepine -- 3.5.4 Allopurinol -- 3.5.5 Dapsone -- 3.5.6 Asparaginase
001480860 5058_ $$a3.6 Conclusion -- References -- 4: Meeting the Unmet Challenges of Pharmaceutical Research Using Artificial Intelligence -- 4.1 Introduction -- 4.2 AI in the Lifecycle of Pharmaceutical Product -- 4.2.1 In Drug Discovery -- 4.2.2 Forecasting of Physicochemical Properties -- 4.2.3 Forecasting of Pharmacological Activity -- 4.2.4 In Pharmaceutical Product Development -- 4.3 Artificial Neural Network -- 4.3.1 ANN vs. Human Brain -- 4.3.2 Theory of ANN -- 4.3.3 The Architecture of ANNs -- 4.3.4 Training -- 4.3.5 Working -- 4.4 Fuzzy Logic -- 4.4.1 Theory of Fuzzy Logic
001480860 506__ $$aAccess limited to authorized users.
001480860 520__ $$aThis book covers several important aspects of pharmaceutical research and innovations. It presents important topics on drug delivery, novel microsponge, nanocrystals, polymeric nanoparticles, peptide synthesis, biopharmaceuticals, pharmacodynamics, yeast flocculation, neuromodulators, innovative drug discovery, pharmacoinformatics, aminoquinoline, thiourea crystals for API synthesis, FDCs and formulations research, ayurveda and natural products, and innovations to militate anti-microbial resistance (AMR). A chapter is devoted to the applications of Artificial Intelligence and Machine Learning in diverse sectors of the pharmaceutical industry, including drug discovery and development, drug repurposing, and improving pharmaceutical productivity. The book also reviews the role of pharmacogenomics and pharmacogenetics in drug development and precision medicine. Further, the book presents an updated summary of recent advances in the fields of nanomedicines and nano-based drug delivery systems. This book is useful to pharmaceutical sciences students, researchers, educators, and professionals in the pharmaceutical industry to understand the intricacies of new drug research and innovations.
001480860 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed September 27, 2023).
001480860 650_6 $$aTechniques pharmaceutiques.
001480860 650_6 $$aMédicaments$$xDéveloppement$$xInnovations.
001480860 650_0 $$aPharmaceutical technology.
001480860 650_0 $$aPharmaceutical industry$$xTechnological innovations.$$xLaw and legislation$$0(DLC)sh 85039735
001480860 650_0 $$aDrug development$$xTechnological innovations.
001480860 655_0 $$aElectronic books.
001480860 7001_ $$aSingh, Prati Pal.
001480860 77608 $$iPrint version:$$aSingh, Prati Pal$$tRecent Advances in Pharmaceutical Innovation and Research$$dSingapore : Springer,c2023$$z9789819923014
001480860 852__ $$bebk
001480860 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-981-99-2302-1$$zOnline Access$$91397441.1
001480860 909CO $$ooai:library.usi.edu:1480860$$pGLOBAL_SET
001480860 980__ $$aBIB
001480860 980__ $$aEBOOK
001480860 982__ $$aEbook
001480860 983__ $$aOnline
001480860 994__ $$a92$$bISE