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001481038 001__ 1481038
001481038 003__ OCoLC
001481038 005__ 20231031003320.0
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001481038 008__ 230923s2023\\\\si\\\\\\ob\\\\000\0\eng\d
001481038 019__ $$a1398569263
001481038 020__ $$a9789819943180$$qelectronic book
001481038 020__ $$a9819943183$$qelectronic book
001481038 020__ $$z9819943175
001481038 020__ $$z9789819943173
001481038 0247_ $$a10.1007/978-981-99-4318-0$$2doi
001481038 035__ $$aSP(OCoLC)1399167413
001481038 040__ $$aEBLCP$$beng$$erda$$cEBLCP$$dYDX$$dGW5XE$$dEBLCP$$dYDX
001481038 049__ $$aISEA
001481038 050_4 $$aQH447$$b.C44 2023
001481038 08204 $$a572.8/6$$223/eng/20230928
001481038 1001_ $$aChhaya, Pradeep,$$eauthor.
001481038 24514 $$aThe topological model of genome and evolution :$$bunderstanding the origin and nature of life /$$cPradeep Chhaya.
001481038 264_1 $$aSingapore :$$bSpringer,$$c[2023]
001481038 300__ $$a1 online resource
001481038 336__ $$atext$$btxt$$2rdacontent
001481038 337__ $$acomputer$$bc$$2rdamedia
001481038 338__ $$aonline resource$$bcr$$2rdacarrier
001481038 500__ $$a3.16 Genotopic Architecture of Genome
001481038 504__ $$aIncludes bibliographical references.
001481038 5050_ $$aIntro -- Preface -- Introduction -- Contents -- About the Author -- 1: Nature of Life: Structuralism and Functionalities -- 1.1 Introduction -- 1.2 Life as a Natural Phenomenon -- 1.3 What Separates Life from Other Natural Phenomena -- 1.4 Why Does Life Defy Formal Definition? -- 1.5 Involuted Manifold Model of a Typical Natural Phenomenon -- 1.6 Involuted Manifold Model of Life -- 1.7 The Reason Why Life Is Difficult to Be Formalized -- 1.8 Is There a Common Structure of Life? -- 1.9 Are There Any Definitive Functionalities of Life?
001481038 5058_ $$a1.10 The Semantics of This Relationship Between Structuralism and Functionalities -- 1.11 Why Does Life Defy Common Semantics? -- 1.12 Involuted Model of the Relationship Between Structuralism and Functionalities -- 1.13 Involuted Model of Biological Structuralism and Functionalities -- 1.14 Involuted Model of Natural Selection -- 1.15 Conventional Perspective of Natural Selection -- 1.16 Why Natural Selection Cannot Be Rationalized by the Conventional Model -- 1.17 Need to Reinterpret Darwinian Paradigm -- 1.18 Conclusion -- References
001481038 5058_ $$a2: Nature of Relationship Between a Genotype and Phenotype -- 2.1 Introduction -- 2.2 Formal Description of the Relationship Between Structuralism and Functionalities -- 2.3 Comparison with the Relationship Between Genotype and Phenotype -- 2.4 Generic Description of Dualities -- 2.5 Significance of Genotype and Phenotype -- 2.6 Conventional Perspective of the Relationship Between Genotype and Phenotype -- 2.7 Semantic Ambiguities of the Conventional Perspective -- 2.8 Origins of Semantic Ambiguities -- 2.9 Can We Redefine Genotype and Phenotype Within the Darwinian Paradigm?
001481038 5058_ $$a2.10 Problem of Complexity in the Darwinian Paradigm -- 2.11 Semantics of Complexity in Biological Evolution -- 2.12 Why Do We Need to Reinterpret Darwinian Theory? -- 2.13 Emergence of Complexity in the Involuted Model -- 2.14 Redefining Genotype and Phenotype -- 2.15 New Explanation of the Emergence of Complexity -- 2.16 Role of Genotype and Phenotype in the Emergence of Complexity -- 2.17 Semantics of Dualities -- 2.18 Conclusion -- References -- 3: Nature of Genomic Architecture: A Topological Model of Genome -- 3.1 Introduction -- 3.2 Conventional Perspective of Natural Selection
001481038 5058_ $$a3.3 Proposed Model of Natural Selection -- 3.4 Postulate of Natural Selection -- 3.5 Explicit Genomic Architecture -- 3.6 Implicit Genomic Architecture -- 3.7 Postulate of Genomic Architecture -- 3.8 Functional Genome Versus Structural Genome -- 3.9 Nature of Long-Range Influences in Genome -- 3.10 Postulate of Long-Range Influences -- 3.11 Units of Selection Versus Units of Inheritance -- 3.12 Topological Model of Genomic Unit Genotope -- 3.13 Semantics of Genotope -- 3.14 The Relationship Between Genotype and Phenotype Using Genotope -- 3.15 Natural Selection and Genotope
001481038 506__ $$aAccess limited to authorized users.
001481038 520__ $$aThis book deals with the missing link in the domain of functional genomics viz. genomic architecture. It begins with a deconstruction of the Darwinian paradigm using the proposed model of modified involuted manifolds. It recasts the process of natural selection as a process of information transfer. Using a topological model, this book outlines a new genomic architecture. The key argument for this proposed model is that some such structuralism has always been implicit in genomics. The proposed model fits very well with the known genomic characteristics and allows to separate the regulatory genome from the transcriptive genomes. The model is capable of discerning modular architecture of genomes with different genomic functionalities existing in hierarchical relationships and demonstrates that genomes act as units of selection and as the environment for the individual genes which act as competing species. Towards the end, the book also examines the role of genomic evolution in cancer and the principles of natural selection and evolution of the genotype. The regulatory genome is also discussed, with an emphasis on its evolution and natural selection. It is a valuable source for researchers working in functional genomics, mathematical modeling in biology and evolutionary genomics. .
001481038 588__ $$aDescription based on online resource; title from digital title page (viewed on October 24, 2023).
001481038 650_0 $$aFunctional genomics.$$0(DLC)sh2003008319
001481038 650_0 $$aEvolutionary genetics.
001481038 655_0 $$aElectronic books.
001481038 77608 $$iPrint version:$$aChhaya, Pradeep$$tThe Topological Model of Genome and Evolution$$dSingapore : Springer,c2023$$z9789819943173
001481038 852__ $$bebk
001481038 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-981-99-4318-0$$zOnline Access$$91397441.1
001481038 909CO $$ooai:library.usi.edu:1481038$$pGLOBAL_SET
001481038 980__ $$aBIB
001481038 980__ $$aEBOOK
001481038 982__ $$aEbook
001481038 983__ $$aOnline
001481038 994__ $$a92$$bISE