Health risk assessment of environmental chemicals : pre-emptive and integrated approaches / Masami Ishido.
Ishido, Masami.
2023
RA1226
Available Online

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Title Health risk assessment of environmental chemicals : pre-emptive and integrated approaches / Masami Ishido.
Author Ishido, Masami.
ISBN 9789819915606 (electronic bk.)
9819915600 (electronic bk.)
9819915597
9789819915590
DOI https://doi.org/10.1007/978-981-99-1560-6
Imprint Singapore : Springer, 2023.
Language English
Description 1 online resource (303 p.)
Other Standard Identifiers 10.1007/978-981-99-1560-6 doi
Call Number RA1226
Dewey Decimal Classification 615.9/02
Summary This book presents the frontier research of toxicology and health risk assessment of chemicals. First, it provides an overview of the current methods of evaluating safety amounts of chemicals and provides a new aspect of the principle of toxicology. Secondly, it shows recent research where the new method of health risk evaluation is adopted, followed by an integrated health risk assessment of chemicals. Finally, it describes the epigenetic inheritance of chemical impact on health throughout several generations. Estimating the safety amount of chemicals surrounding our lives is not sufficient for health risk evaluation, particularly for carcinogenic compounds, endocrine disruptors, and nano materials. The authors group has found a family of chemicals linked to ADHD through animal screening and identified its chemical nature using chemoinformatics methods. Based on these new developments, this book proposes to utilize the biomarker common to those chemicals for health risk assessment, independent of exposure routes and physiological dimensions. The book appeals to researchers and students in the field of toxicology, health risk assessment, pharmacology, and public health.
Note 8.2.1 Contact Toxicity
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed September 28, 2023).
Available in Other Form Health Risk Assessment of Environmental Chemicals
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
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Intro
Preface
Acknowledgments
Contents
Chapter 1: Introduction
References
Part I: Current Health Risk Assessment of Chemicals
Chapter 2: The Safe Dose in the Utilization of Chemicals
2.1 Dose-Response Curve
2.2 Health Risk Assessment of Rotenone and Simazine
2.2.1 Rotenone
2.2.2 Simazine
2.3 Health Risk Assessment of Dioxin-Induced Malformation of Reproductive Organs
References
Chapter 3: Carcinogens
3.1 Carcinogens
3.2 Health Risk Assessment of Carcinogens
3.2.1 Long-Term Carcinogenicity Studies

3.2.2 Carcinogenicity Studies with Surrogates
3.3 Dose-Response Curve and Carcinogenic Mechanism of Benzo[a]Pyrene
3.3.1 Carcinogenic Mechanism of Benzo[a]Pyrene
3.4 Various Carcinogens and their Dose-Response Curves
3.5 Research on Carcinogens by Prof. Shoji Fukushima
3.6 Dose-Response Curve of TPA (12-O-Tetradecanoylphorbol 13-Acetate)
3.7 How to Interpret the Dose-Response Curve
3.8 Health Risk Assessment of Radiation
3.9 Genome Mutation
3.9.1 Mutation as a Factor in the Evolution
3.9.2 Mutation as a Factor of Carcinogenesis

3.9.3 Establishment of Mutagenicity Study Methods
3.10 Characteristics of Cancer
3.10.1 Carcinogenic Process in Colorectal Cancer
3.11 Ideas Relating to the Health Risk Assessment of Carcinogens
3.12 Concept of the Lifetime Risk of Carcinogenesis
3.12.1 Carcinogenic Risk of Benzo[a]Pyrene
3.12.2 Carcinogenic Risk of Chlordane
3.12.3 Benchmark Dose Method (BMDL: Benchmark Dose Lower Confidence Level)
3.13 Experiment on Cells with a Tumorigenic Probability of 10-6
3.14 The Signature of Cancer Genome Mutation
References
Chapter 4: Endocrine Disruptors

4.1 Dose Response of Endocrine Hormones
4.2 Dose Response of Bisphenol A
4.3 Carcinogenicity Evaluation of Bisphenol A
4.4 Health Risk Assessment of Bisphenol A
4.5 Strict Set Values for EU
References
Chapter 5: Nanomaterials
5.1 Physical Properties of Nanomaterials
5.2 Nanomaterials
5.2.1 Physicochemical Properties of Carbon Nanotubes
5.3 Dose-Response Curve of Nanomaterials
5.4 Carcinogenicity Evaluation of Carbon Nanotube
5.4.1 Health Risk Assessment of MWNT-7
References
Chapter 6: Epigenetic Chemicals
6.1 Epigenetic Chemicals

6.2 The Impact of Arsenic on the Epigenetic Mechanism
References
Chapter 7: Toward the Integrated Health Risk Assessment of Chemicals
7.1 Toxicology, Epidemiology, and Health Risk Assessment
7.2 Predominance of the Epidemiological Data
7.3 Dichloromethane (DCM) and 1,2-Dichloropropane (1,2-DCP)
7.3.1 Recent Cases of Cholangiocarcinoma
References
Part II: New Concepts of Toxicological Mechanisms of Chemicals
Chapter 8: Expanded Toxicological Mechanisms of Chemicals
8.1 A Strategy for New Aspects of Health Risk Assessment
8.2 Three Exposure Routes of Chemicals

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