Obesity, diabetes and inflammation : molecular mechanisms and clinical management / Dimiter Avtanski, Leonid Poretsky, editors.
Avtanski, Dimiter.; Poretsky, Leonid, 1954-
2023
RC628
Available Online

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Title
Obesity, diabetes and inflammation : molecular mechanisms and clinical management / Dimiter Avtanski, Leonid Poretsky, editors.
ISBN
9783031397219 (electronic bk.)
3031397215 (electronic bk.)
3031397207
9783031397202
DOI
https://doi.org/10.1007/978-3-031-39721-9
Publication Details
Cham : Springer, 2023.
Language
English
Description
1 online resource (235 p.).
Item Number
10.1007/978-3-031-39721-9 doi
Call Number
RC628
Dewey Decimal Classification
616.398
Summary
Obesity is a worldwide epidemic that affects half a billion people. It has been estimated that, if current trends continue, by 2050, 60% of men and 50% of women worldwide will be obese. Hypertrophy and hyperplasia of white adipose tissue caused by overweight and obesity lead to a chronic inflammatory state, which results in impaired insulin sensitivity and the development of diabetes. Currently, the number of people affected by diabetes globally exceeds 400 million (rising more rapidly in low- and middle-income countries). In 2019, diabetes was the ninth leading cause of mortality, with an estimated 1.5 million direct deaths. This book provides a comprehensive overview of the relationship between inflammation, obesity, and diabetes. It focuses on the pathogenesis and biological mechanisms of obesity, the interaction between adipose tissue and the immune system, the role of genetic and environmental factors, the progression of cardiovascular complications, and the association of obesity and inflammation with type 1 and type 2 diabetes, as well as gestational diabetes. This volume also includes practical recommendations for preventing and managing these conditions using both lifestyle modifications and pharmacological interventions. Written by experts in the field, Obesity, Diabetes and Inflammation: Molecular Mechanisms and Clinical Management addresses the role of inflammation in both obesity and diabetes, its effect on vascular and non-vascular pathologies, oxidative stress, genetics, and epigenetics. This text aims to be a valuable resource for researchers, clinicians, and students of medicine at all levels.
Note
Introduction
Includes index.
Access Note
Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed October 12, 2023).
Added Author
Avtanski, Dimiter.
Poretsky, Leonid, 1954-
Series
Contemporary endocrinology (Totowa, N.J.)
Available in Other Form
Obesity, Diabetes and Inflammation
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Online Access
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Intro
Preface
Contents
Chapter 1: Inflammation: Pathogenesis and Biological Markers
Introduction
Brief History and Definitions
Clinical Biomarkers
Immunology of Inflammation
Innate Immune System
Cells of the Innate Immune System
Molecular Components of the Innate Immune System
Adaptive Immune System
Components of Adaptive Immunity
Chronic Inflammation Associated with Adaptive Immunity
Anti-Inflammatory Therapy
Conclusions
References
Chapter 2: Obesity and Inflammation
Introduction
Obesity
Adipose Tissue

Introduction
Epidemiology and Risk Factors
Genetics
Inflammation, the Immune System, and Diabetes
The Role of Cytokines in the Development of Diabetes
Immune Checkpoint Inhibitor-Induced Diabetes
Treatment
Metformin
Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists
Sodium-Glucose Co-Transporter 2 Inhibitors
Immune-Based Therapies
Systemic Inflammation and Diabetes
Conclusions
References
Chapter 4: Diabetes, Obesity, and Oxidative Stress
Introduction
Oxidative Stress
Obesity, Diabetes and Insulin Resistance

Key Molecular Mechanisms of Obesity, IR and DM Include Mitochondrial Dysfunction, ER Stress and ROS-Induced DNA Damage, which Are Closely Connected with the Major Cellular Disturbances Caused by OS
Mitochondrial Dysfunction
Endoplasmic Reticulum Stress
ROS-Induced DNA Damage
Conclusions
References
Chapter 5: Advanced Glycation End Products and Diabetes
Advanced Glycation End Products: Sources, Metabolism, Interaction with Receptors
Exogenous AGEs
Endogenous AGEs
Metabolism of AGEs
Interaction of AGEs with Receptors

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