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001481283 001__ 1481283
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001481283 019__ $$a1400971857
001481283 020__ $$a9789819938100$$q(electronic bk.)
001481283 020__ $$a9819938104$$q(electronic bk.)
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001481283 0247_ $$a10.1007/978-981-99-3810-0$$2doi
001481283 035__ $$aSP(OCoLC)1401057953
001481283 040__ $$aEBLCP$$beng$$cEBLCP$$dYDX$$dGW5XE
001481283 049__ $$aISEA
001481283 050_4 $$aRC643
001481283 08204 $$a616.99419$$223/eng/20231013
001481283 24500 $$aPathogenesis and treatment of leukemia /$$cHarinder Gill, Yok-Lam Kwong, editors.
001481283 260__ $$aSingapore :$$bSpringer,$$c2023.
001481283 300__ $$a1 online resource (663 p.)
001481283 500__ $$a4.2 Flow Cytometry in the Diagnosis of Acute Leukaemia
001481283 5050_ $$aIntro -- Contents -- 1: Basic Hematopoiesis and Leukemia Stem Cells -- 1.1 Introduction -- 1.2 Hematopoietic Stem and Progenitor Cells -- 1.2.1 Hematopoietic Stem and Progenitor Cell Heterogeneity -- 1.2.2 Lineage Commitment from the Hematopoietic Stem and Progenitor Cell -- 1.3 Hematopoietic Stem and Progenitor Cell Assays -- 1.3.1 Phenotypic Characterization -- 1.3.2 Colony Forming Unit (CFU) and Long-Term Culture-Initiating Cell (LT-CIC) Assays -- 1.3.3 Xenotransplantation Studies -- 1.4 Hematopoietic Stem and Progenitor Cell Expansion
001481283 5058_ $$a1.5 Aging Hematopoiesis, Including Telomeres -- 1.5.1 Influence of Aging on Hematopoiesis -- 1.5.2 Telomeres in Hematopoiesis -- 1.6 Leukemic Stem Cells -- References -- 2: Modern Classification of Acute and Chronic Leukemias: Integrating Biology, Clinicopathologic Features, and Genomics -- 2.1 Introduction -- 2.2 Myeloproliferative Neoplasms (MPN) -- 2.3 Myeloid/Lymphoid Neoplasms with Eosinophilia and Tyrosine Kinase Gene Fusions (MLN-TK) -- 2.4 Mastocytosis -- 2.5 Myelodysplastic/Myeloproliferative Neoplasms -- 2.6 Myelodysplastic Syndromes or Myelodysplastic Neoplasms (MDS)
001481283 5058_ $$a2.7 Acute Myeloid Leukemia -- References -- 3: Molecular Techniques in the Diagnosis and Monitoring of Acute and Chronic Leukaemias -- 3.1 Introduction -- 3.2 Short-Read NGS -- 3.3 General Principles of NGS -- 3.4 DNA Sequencing -- 3.4.1 Principles of NGS Assay Design -- 3.4.1.1 Panel Selection -- 3.4.1.2 Gene Selection in Panel Sequencing -- 3.4.1.3 Considerations of Variant Types During Panel Design -- 3.4.2 Bioinformatic Analysis for Variant Detection -- 3.4.2.1 Pre-processing Procedures -- 3.4.2.2 Variant Calling for SNVs and Short Indels -- 3.4.2.3 Variant Annotation
001481283 5058_ $$a3.4.2.4 Variant Calling for Long Indels -- 3.4.2.5 Detection of CNVs at the Gene Level -- 3.4.3 Specific Applications of DNA Sequencing Strategies in Leukaemias -- 3.4.3.1 Molecular Consensus Sequencing for Detection of Subclonal or Rare Variants -- 3.4.3.2 Evaluation of Immunoglobulin/T-Cell Receptor Genes -- 3.5 RNA Sequencing -- 3.5.1 Principles of Assay Design -- 3.5.2 Bioinformatic Considerations for RNA Sequencing -- 3.6 Molecular Monitoring of Measurable Residual Disease -- 3.7 Real-Time Quantitative PCR -- 3.7.1 Principles -- 3.7.2 MRD Monitoring in CML
001481283 5058_ $$a3.7.3 RQ-PCR Monitoring in Other Leukaemias -- 3.8 Digital PCR -- 3.8.1 Principles -- 3.8.2 Considerations on Analytical Sensitivity in DPCR -- 3.9 Gene Expression Profiling -- 3.10 Brief Review of GEP Platforms -- 3.11 Clinical Applications of GEP in Leukaemias -- 3.12 Newer Techniques -- 3.12.1 Long-Read Sequencing -- 3.12.2 Single-Cell Sequencing -- 3.12.3 Optical Mapping -- 3.12.4 Circulating Tumour DNA Testing in Leukaemia -- 3.13 Conclusion -- References -- 4: Flow Cytometric Techniques in the Diagnosis and Monitoring of Acute Leukaemias -- 4.1 Introduction
001481283 506__ $$aAccess limited to authorized users.
001481283 520__ $$aThis book covers a comprehensive update on acute and chronic leukemia. In 54 chapters, authors introduce research progress and clinical trials of acute myeloid leukaemia (AML), acute promyelocytic leukaemia (APL), acute lymphoblastic leukaemia (ALL), myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN) and chronic myeloid leukemia (CML). The last decade has seen the integration of genetic and clinical information to determine the prognosis and treatment strategies. This book provides practitioners, researchers and graduate students of Hematology and Hematopathology a comprehensive update on the pathobiology, genomics, classification, diagnosis, monitoring, prognostication and therapy of both acute and chronic leukemias.
001481283 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed October 13, 2023).
001481283 650_0 $$aLeukemia.$$0(DLC)sh 90001715
001481283 655_0 $$aElectronic books.
001481283 7001_ $$aGill, Harinder.
001481283 7001_ $$aKwong, Yok-Lam.
001481283 77608 $$iPrint version:$$aGill, Harinder$$tPathogenesis and Treatment of Leukemia$$dSingapore : Springer Singapore Pte. Limited,c2023$$z9789819938094
001481283 852__ $$bebk
001481283 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-981-99-3810-0$$zOnline Access$$91397441.1
001481283 909CO $$ooai:library.usi.edu:1481283$$pGLOBAL_SET
001481283 980__ $$aBIB
001481283 980__ $$aEBOOK
001481283 982__ $$aEbook
001481283 983__ $$aOnline
001481283 994__ $$a92$$bISE