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001481436 001__ 1481436
001481436 003__ OCoLC
001481436 005__ 20231031003338.0
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001481436 008__ 231016s2023\\\\sz\\\\\\o\\\\\000\0\eng\d
001481436 019__ $$a1401618637$$a1402029768$$a1402814923
001481436 020__ $$a9783031397257$$q(electronic bk.)
001481436 020__ $$a3031397258$$q(electronic bk.)
001481436 020__ $$z303139724X
001481436 020__ $$z9783031397240
001481436 0247_ $$a10.1007/978-3-031-39725-7$$2doi
001481436 035__ $$aSP(OCoLC)1403565494
001481436 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dEBLCP$$dYDX
001481436 049__ $$aISEA
001481436 050_4 $$aQP801.P8
001481436 08204 $$a547/.596$$223/eng/20231016
001481436 24500 $$aPurinergic receptors and their modulators /$$cVittoria Colotta, Claudiu T. Supuran, editors.
001481436 264_1 $$aCham, Switzerland :$$bSpringer,$$c2023.
001481436 300__ $$a1 online resource (240 pages).
001481436 336__ $$atext$$btxt$$2rdacontent
001481436 337__ $$acomputer$$bc$$2rdamedia
001481436 338__ $$aonline resource$$bcr$$2rdacarrier
001481436 4901_ $$aTopics in medicinal chemistry ;$$vvolume 41
001481436 5050_ $$aOnce upon a time adenosine and its receptors. Historical survey and perspectives as potential targets for therapy in human diseases -- Adenosine receptor ligands, probes and functional conjugates: A twenty-year history of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines (PTP) -- Adenosine receptor ligands as potential therapeutic agents for impaired wound healing and fibrosis -- Adenosine A2A receptor antagonists: chemistry, SARs, modeling studies and therapeutic potential -- A2B Adenosine Receptor as a new and attractive target to treat brain ischemia or demyelination -- A3 adenosine receptor ligands: from discovery to clinical trials -- Bifunctional tools to study adenosine receptors -- Allosteric modulators of adenosine receptors -- New computational approaches in inspecting adenosine receptor-ligand recognition process -- P2X4 receptors in immunity and inflammation -- CD73 inhibitors as antitumor agents -- Bacterial ectonucleotidases- underexplored antibacterial targets.
001481436 506__ $$aAccess limited to authorized users.
001481436 520__ $$aThis book overviews purinergic receptors that are playing key roles in human and pathophysiological processes. The book elaborates on how selective P1 and P2 modulators have been developed as therapeutics for a variety of diseases. It also provides an overview of current perspectives in the design of purinergic receptor modulators and future challenges such as the availability of selective ligands for all receptor subtypes. Divided into 12 chapters, this comprehensive volume also offers a multidisciplinary perspective on the historical evolution, starting with a chapter devoted to the roots and early discoveries of adenosine and its receptors, followed by a twenty-year retrospective on the synthesis, properties, and functional potential of adenosine receptor ligands, probes, and functional conjugates. In the next chapters, experts in the field delve into topics such as the therapeutic potential of adenosine receptor ligands in wound healing and fibrosis, the therapeutic benefits of A2A receptor antagonists, the A2B adenosine receptor as a target for brain ischemia or demyelination, the development and latest advancements in clinical trials of A3 adenosine receptor ligands. Other chapters describe bifunctional tools to study adenosine receptors, allosteric modulators of adenosine receptors, and new computational approaches to inspect adenosine receptor-ligand recognition processes. Furthermore, the book discusses the role of P2X4 receptors in immunity and inflammation. The final chapters illustrate CD73 inhibitors as antitumor agents, and bacterial ectonucleotidases as underexplored antibacterial drug targets. This book is a valuable resource for scholars working in the field of medicinal chemistry, as well as researchers in the industry, providing readers with a comprehensive understanding of adenosine receptor biology and its therapeutic potential.
001481436 588__ $$aDescription based on print version record.
001481436 650_0 $$aPurines$$xReceptors.
001481436 650_0 $$aBiological response modifiers.
001481436 655_0 $$aElectronic books.
001481436 7001_ $$aColotta, Vittoria,$$eeditor.
001481436 7001_ $$aSupuran, Claudiu T.,$$d1962-$$eeditor.
001481436 77608 $$iPrint version:$$tPURINERGIC RECEPTORS AND THEIR MODULATORS.$$d[Place of publication not identified] : SPRINGER INTERNATIONAL PU, 2023$$z303139724X$$w(OCoLC)1388317859
001481436 830_0 $$aTopics in medicinal chemistry (Springer (Firm)) ;$$vv. 41.
001481436 852__ $$bebk
001481436 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-39725-7$$zOnline Access$$91397441.1
001481436 909CO $$ooai:library.usi.edu:1481436$$pGLOBAL_SET
001481436 980__ $$aBIB
001481436 980__ $$aEBOOK
001481436 982__ $$aEbook
001481436 983__ $$aOnline
001481436 994__ $$a92$$bISE