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001481488 005__ 20231031003340.0
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001481488 0247_ $$a10.1007/978-981-99-4886-4$$2doi
001481488 035__ $$aSP(OCoLC)1404264660
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001481488 08204 $$a571.6/5$$223/eng/20231017
001481488 24500 $$aPhase separation in living cells :$$bbenefits and risks /$$cRiki Kurokawa, editor.
001481488 264_1 $$aSingapore :$$bSpringer,$$c2023.
001481488 300__ $$a1 online resource (309 pages) :$$billustrations (black and white, and color).
001481488 336__ $$atext$$btxt$$2rdacontent
001481488 337__ $$acomputer$$bc$$2rdamedia
001481488 338__ $$aonline resource$$bcr$$2rdacarrier
001481488 5050_ $$aChapter 1. FUS aggregation by shear stress on pipetting and its suppression by non-coding RNA -- Chapter 2. Basics and recent advances in computational and theoretical methods for understanding the liquid-liquid phase separation -- Chapter 3.Promotion of liquid-liquid phase separation by G-quadruplex DNA and RNA -- Chapter 4. Phase regulation by chaperons -- Chapter 5. Regulation of aggregation of intrinsically disordered protein through phase separation: Risk management of phase separation -- Chapter 6. Molecular mechanisms of phase transition/separation of protein low-complexity sequences -- Chapter 7. Winding and Tangling. An Initial Phase of Membrane-less Organelle Formation (from a viewpoint of Cajal Bodies) -- Chapter 8. Formation and function of phase separated nuclear bodies directed by architectural noncoding RNA -- Chapter 9. Force-dependent remodeling of cell-to-cell adhesion through the regulation of phase separation -- Chapter 10. Neuronal RNA granules: Phase separation, dynamics, and higher brain functions -- Chapter 11. Liquid-liquid phase separation in structure and function of nuclear pore complex -- Chapter 12. Phase Separation Orchestrates Cancer Signaling: Biomolecular condensates as a promising target for cancer therapy -- Chapter 13. Regulatory interaction of intrinsically disordered regions of pathogenic proteins in neurodegenerative diseases -- Chapter 14. Functional properties of phase separation and intranuclear complex of FUS in the pathogenesis of ALS/FTLD -- Chapter 15. Functional responses of microglia to amyloid plaques -- Chapter 16. Emerging role of phage separation in COVID-19.
001481488 506__ $$aAccess limited to authorized users.
001481488 520__ $$aThis book presents the latest cutting-edge research on phase separation. It discusses the benefits and risks of phase separation for living cells from the perspectives of physics, chemistry, biology, and medicine. Phase separation is a physico-chemical process that induces a single solution of solvent and intrinsically disordered proteins (IDPs) to separate into two phases, one phase containing only solvent and the other containing IDPs in the solvent. A key molecule in phase separation is the intrinsically disordered region (IDR) proteins (IDPs), mostly comprised of RNA-binding proteins (RBPs). One of the major roles of phase separation is to generate condensates, membrane-less organelles including stress granule, Cajal body, and nucleolus. Biological actions of phase separation in various aspects of science have received increasing attention in recent years. The book consists of four parts; Part I on physics and chemistry includes topics on structural biology of RBP FUS/TLS and chaperone for phase separation, computational approach of phase separation, and chemistry of G-quadruplex of DNA and RNA. Part II on molecular biology presents molecular mechanism of IDR sequence phase separation and potential cellular function of these labile fibers, formation of membrane-less organelles, and roles of noncoding RNAs in phase separation. Part III on biology covers topics from nuclear pore complex, developmental biology regarding force-dependent remodeling, and neurobiology and higher order brain functions. Finally, Part IV on medicine presents condensates and cancer therapy, pathogenesis of neurodegenerative diseases based on IDPs, and responses of microglia to amyloid. The last chapter highlights the latest topic on how the SARS-Cov-2 virus takes advantage of phase separation for its infections. This book brings together the studies of phase separation in each area in a single volume. The comprehensive approach provides new insights to the research and will benefit the readers by responding to the emerging needs for understanding phase separation.
001481488 588__ $$aDescription based on print version record.
001481488 650_0 $$aCell organelles.
001481488 650_0 $$aBiochemistry.
001481488 655_0 $$aElectronic books.
001481488 7001_ $$aKurokawa, Riki,$$eeditor.
001481488 77608 $$iPrint version:$$tPHASE SEPARATION IN LIVING CELLS.$$d[Place of publication not identified] : SPRINGER VERLAG, SINGAPOR, 2023$$z9819948851$$w(OCoLC)1385301154
001481488 852__ $$bebk
001481488 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-981-99-4886-4$$zOnline Access$$91397441.1
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001481488 980__ $$aBIB
001481488 980__ $$aEBOOK
001481488 982__ $$aEbook
001481488 983__ $$aOnline
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