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001482378 019__ $$a1402810453
001482378 020__ $$a9783031426483$$q(electronic bk.)
001482378 020__ $$a3031426487$$q(electronic bk.)
001482378 020__ $$z3031426479
001482378 020__ $$z9783031426476
001482378 0247_ $$a10.1007/978-3-031-42648-3$$2doi
001482378 035__ $$aSP(OCoLC)1402813094
001482378 040__ $$aEBLCP$$beng$$cEBLCP$$dGW5XE$$dYDX$$dOCLCO
001482378 049__ $$aISEA
001482378 050_4 $$aRM301$$b.S48 2023
001482378 08204 $$a615.1$$223/eng/20231023
001482378 24500 $$aSex and gender effects in pharmacology /$$cStella E. Tsirka, Maricedes Acosta-Martinez, editors.
001482378 260__ $$aCham :$$bSpringer,$$c2023.
001482378 300__ $$a1 online resource (286 p.).
001482378 4901_ $$aHandbook of Experimental Pharmacology ;$$vv.282
001482378 500__ $$a7 Implications for Pain Treatment
001482378 5050_ $$aIntro -- Preface -- Contents -- Part I: Pharmacological Basic Principles -- The Impact of Sex and Gender in Medicine and Pharmacology -- 1 Historical Development -- 2 Basic Research -- 2.1 Immune Response -- 2.2 Animals and Cells -- 3 Clinical Trials -- 4 Pharmacology -- 4.1 Sex Differences -- 4.2 Gender Differences -- 5 Epidemiology, Health Care Research, and Prevention Research -- 6 Sex and Gender and Personalized Medicine -- 7 Implementation of Sex and Gender Sensitive Medicine -- 8 Conclusion -- References -- Sex Differences in Pharmacokinetics -- 1 Introduction -- 2 Methods
001482378 5058_ $$a3 Results and Discussion -- 3.1 Sex Differences in PKs Correlate with Sex Differences in ADRs -- 3.2 Factors Influencing Sex Differences in Pharmacokinetics -- 3.3 Selection of the Appropriate Drug Dose -- 3.4 Limitations in Population PK Studies -- 4 General Conclusions and Future Directions -- References -- Clinical Pharmacological Considerations in Transgender Medicine -- 1 Introduction -- 1.1 Terminology -- 1.2 US Demographics -- 1.3 Health Disparities and Co-occurring Medical Conditions -- 1.3.1 Barriers to Healthcare Access -- 1.3.2 Chronic Disease Burden
001482378 5058_ $$a1.3.3 Considerations Across the Lifespan -- 2 Pharmacologic Considerations for TGD Adults Undergoing Hormone Therapy -- 2.1 TGD-Inclusive Pharmacologic Research -- 2.2 Overview of Hormone Therapy -- 2.3 Drug Absorption -- 2.4 Drug Distribution -- 2.5 Drug Metabolism -- 2.6 Drug Elimination -- 2.7 Drug Transport -- 3 Limitations of Sex/Gender as Binary Variable in Biomedical and Pharmacologic Research -- 4 Conclusions and Clinical Implications -- References -- Sex and Gender Differences in the Pharmacology of the Overactive Urinary Bladder -- 1 Introduction -- 2 Healthy Bladder and Its Physiology
001482378 5058_ $$a2.1 Clinical Data -- 2.2 Gross Anatomy and Histology -- 2.3 Experimental Data -- 2.3.1 Contraction Studies -- 2.3.2 Relaxation Studies -- 2.3.3 Proposed Factors of Bladder Pathophysiology -- 3 Pathophysiology in OAB -- 3.1 Clinical Data -- 3.2 Experimental Data -- 4 Treatment Responses -- 5 Conclusions and Research Directions -- References -- Part II: Pathologies of the Brain -- Sex Differences in the Evaluation and Treatment of Stroke -- 1 Sex Differences in Stroke -- 2 Epidemiology -- 3 Stroke Symptoms -- 4 Outcomes -- 5 Estrogen and Stroke -- 6 Stroke Etiology -- 7 Atrial Fibrillation
001482378 5058_ $$a8 Treatment of Acute Ischemic Strokes -- 8.1 Thrombolysis -- 9 Carotid Intervention -- 9.1 Endovascular Interventions -- 10 Treatment of Intracerebral Hemorrhage -- 11 Pregnancy -- 12 Secondary Stroke Prevention -- 12.1 Antiplatelets -- 13 Pitfalls in Research and the Way Forward -- References -- Sex Differences in Pain and Its Treatment -- 1 Introduction -- 2 Sex Differences in Pain -- 3 Sex Differences in Response to Experimental Pain -- 4 Sex Differences in Pain: A Clinical Perspective -- 5 Possible Explanations for Sex Differences in People with Pain -- 6 Sex Differences in Pain Treatment
001482378 506__ $$aAccess limited to authorized users.
001482378 520__ $$aBiological sex and gender have a tremendous impact on the efficacy and safety of pharmacological interventions in virtually every disease state. This book presents a comprehensive and up-to-date overview on how sex-specific information is guiding the diagnosis and treatment of diseases affecting men and women, as well as of disease states that disproportionally affects women. Experts in various fields discuss both preclinical and clinical research that is contributing to a better understanding of the impact of sex in the presentation, etiology, treatment, and disease outcomes. Also discussed are the challenges encountered in implementing this growing body of knowledge into practice, as well as possible avenues to recognize and reduce health disparities between men and women so that therapeutic interventions are tailored and improved.
001482378 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed October 23, 2023).
001482378 650_6 $$aPharmacologie$$xDifférences entre sexes.
001482378 650_6 $$aMédicaments$$xDifférences entre sexes.
001482378 650_0 $$aPharmacology$$xSex differences.
001482378 650_0 $$aDrugs$$xSex differences.$$0(DLC)sh 89007049
001482378 655_0 $$aElectronic books.
001482378 7001_ $$aTsirka, Stella.
001482378 7001_ $$aAcosta-Martinez, Maricedes.
001482378 77608 $$iPrint version:$$aTsirka, Stella E.$$tSex and Gender Effects in Pharmacology$$dCham : Springer International Publishing AG,c2023$$z9783031426476
001482378 830_0 $$aHandbook of experimental pharmacology ;$$vv. 282.
001482378 852__ $$bebk
001482378 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-42648-3$$zOnline Access$$91397441.1
001482378 909CO $$ooai:library.usi.edu:1482378$$pGLOBAL_SET
001482378 980__ $$aBIB
001482378 980__ $$aEBOOK
001482378 982__ $$aEbook
001482378 983__ $$aOnline
001482378 994__ $$a92$$bISE