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Table of Contents
Intro
Foreword
Preface
Contents
About the Editors
Chapter 1: Microbial Product Commercialization from Lab to Industry
1.1 Introduction
1.2 Natural and Recombinant Microbial Products and Various Industry Types
1.3 In Lab But Not in Industry
1.4 Basic Processes for Microbial Product Transfer from Lab to Industry
1.4.1 Preparation of Inoculum
1.4.2 Developmental Process of Inoculum for Fermentation
1.4.3 Development of Inoculum Monitoring
1.4.3.1 Inoculum Transfer to the Fermenter Vessel or the Process of Scaling Up
1.4.4 Biological Performances Affected Due To Different Parameters of the Process
1.5 Drawbacks or Hurdles
1.6 Ethical Clearance
1.7 Future Prospects
References
Chapter 2: Assessment of Microbes and Microbial Products for Future Industrialization
2.1 Introduction
2.2 Microbes and Microbial Products in Plant Health and Nutrition
2.3 Microbial Products as Insect Control Agents
2.4 Microbes as Fuel and Energy
References
Chapter 3: Design and Operation of New Microbial Product Bioprocessing System
3.1 Introduction
3.2 Development of Upstream Process
3.2.1 Microbial Bioactive Natural Products
3.2.1.1 Antibiotic
3.2.1.2 Antifungal Agents
3.2.1.3 Anticancer and Antitumor
3.2.1.4 Immunosuppressant and Anti-Inflammatory Agents
3.2.1.5 Antidiabetic, Antiparasitic and Insecticides
3.2.1.6 Biofilm-Inhibitory Agents
3.2.1.7 Biofuels and Bioenergy
3.2.1.8 Microbial Enzymes
3.2.2 Microbial Cell Factories
3.2.2.1 Gram-Negative Bacteria
3.2.2.2 Gram-Positive Bacteria
3.2.2.3 Yeast/Fungi
3.2.2.4 Microbial Consortia
3.2.3 Strategy for Product Enhancement
3.2.3.1 Strain Improvement
3.2.3.2 Protein Engineering
3.2.3.3 Protoplast Fusion
3.2.3.4 Metabolic Engineering
3.2.3.5 Recombinant DNA Technology
3.2.3.6 Mutasynthesis
3.2.3.7 Precursor Engineering Supply
3.2.3.8 Pathway Engineering
3.2.4 Inoculum Development
3.3 Types of Fermentation
3.3.1 Solid State Fermentation (SSF)
3.3.1.1 Factors Influencing of SSF
3.3.2 Submerged Fermentation (SmF)
3.3.2.1 Batch Fermentation
3.3.2.2 Continuous Fermentation
3.3.2.3 Fed-Batch Fermentation
3.3.3 Design of Bioreactor
3.3.4 Linked Bioreactor System
3.4 Bioprocess Optimization
3.5 Process Measurement
3.6 Bioprocess Control
3.7 Recent Progress in Upstream Processing
3.7.1 Quality by Design Approach
3.7.2 Process Analytical Technology
3.7.3 Upstream High-Throughput Cultivation Systems
3.8 Downstream Process
3.8.1 Stages of Downstream Process
3.8.1.1 Cell Disruption
3.8.1.2 Precipitation
3.8.1.3 Flocculation
3.8.1.4 Sedimentation
3.8.1.5 Centrifugation
3.8.1.6 Filtration
3.8.1.7 Solvent Extraction
3.8.1.8 Solvent Recovery
3.8.1.9 Salting Out
3.8.1.10 Chromatography
3.8.2 Product Formulation
3.9 Recent Progress in Downstream Processing
Foreword
Preface
Contents
About the Editors
Chapter 1: Microbial Product Commercialization from Lab to Industry
1.1 Introduction
1.2 Natural and Recombinant Microbial Products and Various Industry Types
1.3 In Lab But Not in Industry
1.4 Basic Processes for Microbial Product Transfer from Lab to Industry
1.4.1 Preparation of Inoculum
1.4.2 Developmental Process of Inoculum for Fermentation
1.4.3 Development of Inoculum Monitoring
1.4.3.1 Inoculum Transfer to the Fermenter Vessel or the Process of Scaling Up
1.4.4 Biological Performances Affected Due To Different Parameters of the Process
1.5 Drawbacks or Hurdles
1.6 Ethical Clearance
1.7 Future Prospects
References
Chapter 2: Assessment of Microbes and Microbial Products for Future Industrialization
2.1 Introduction
2.2 Microbes and Microbial Products in Plant Health and Nutrition
2.3 Microbial Products as Insect Control Agents
2.4 Microbes as Fuel and Energy
References
Chapter 3: Design and Operation of New Microbial Product Bioprocessing System
3.1 Introduction
3.2 Development of Upstream Process
3.2.1 Microbial Bioactive Natural Products
3.2.1.1 Antibiotic
3.2.1.2 Antifungal Agents
3.2.1.3 Anticancer and Antitumor
3.2.1.4 Immunosuppressant and Anti-Inflammatory Agents
3.2.1.5 Antidiabetic, Antiparasitic and Insecticides
3.2.1.6 Biofilm-Inhibitory Agents
3.2.1.7 Biofuels and Bioenergy
3.2.1.8 Microbial Enzymes
3.2.2 Microbial Cell Factories
3.2.2.1 Gram-Negative Bacteria
3.2.2.2 Gram-Positive Bacteria
3.2.2.3 Yeast/Fungi
3.2.2.4 Microbial Consortia
3.2.3 Strategy for Product Enhancement
3.2.3.1 Strain Improvement
3.2.3.2 Protein Engineering
3.2.3.3 Protoplast Fusion
3.2.3.4 Metabolic Engineering
3.2.3.5 Recombinant DNA Technology
3.2.3.6 Mutasynthesis
3.2.3.7 Precursor Engineering Supply
3.2.3.8 Pathway Engineering
3.2.4 Inoculum Development
3.3 Types of Fermentation
3.3.1 Solid State Fermentation (SSF)
3.3.1.1 Factors Influencing of SSF
3.3.2 Submerged Fermentation (SmF)
3.3.2.1 Batch Fermentation
3.3.2.2 Continuous Fermentation
3.3.2.3 Fed-Batch Fermentation
3.3.3 Design of Bioreactor
3.3.4 Linked Bioreactor System
3.4 Bioprocess Optimization
3.5 Process Measurement
3.6 Bioprocess Control
3.7 Recent Progress in Upstream Processing
3.7.1 Quality by Design Approach
3.7.2 Process Analytical Technology
3.7.3 Upstream High-Throughput Cultivation Systems
3.8 Downstream Process
3.8.1 Stages of Downstream Process
3.8.1.1 Cell Disruption
3.8.1.2 Precipitation
3.8.1.3 Flocculation
3.8.1.4 Sedimentation
3.8.1.5 Centrifugation
3.8.1.6 Filtration
3.8.1.7 Solvent Extraction
3.8.1.8 Solvent Recovery
3.8.1.9 Salting Out
3.8.1.10 Chromatography
3.8.2 Product Formulation
3.9 Recent Progress in Downstream Processing