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Table of Contents
Intro
Foreword
Contents
1: The Method Sets the Tone
1.1 Introduction
1.2 The Heroes
1.3 The Endless Revolution
1.3.1 The Hypothesis
1.3.2 The Design
1.3.3 Evidence-Based Dentistry
1.4 Conclusion
References
Evidence-Based Dentistry Related References
2: Preclinical Studies Design and Place of Rodents
2.1 Experimental Animal Model
2.1.1 Animal Species: Naturally-Occurring, Purpose-Bread, and/or Genetically Modified
2.1.2 General Use in Medical Devices Research
2.1.3 Financial Considerations
2.2 Surgical Model
2.2.1 Surgical Anatomical Site and Surgical Procedures for Implant Dentistry
2.2.1.1 Surgical Locations
Extraoral
Anatomy and Histology
Function and Physiology (Movement, Loading)
Advantages/Inconveniences in Implant Dentistry
Recommendations
Intraoral
Anatomy and Histology
Function and Physiology (Movement, Loading, and Occlusion)
Advantages/Inconveniences in Implant Dentistry Anatomy and Histology
Recommendations
2.2.1.2 Surgical Procedures
Extraoral: Description of the Procedures
Animal Welfare, Preparation for Survival Surgery, and Anesthesia (General, Local)
Surgical Step by Step: Anterior-Distal Surface of Femur Metaphysis
Surgical Step-by-Step:Femoral Condyle
Surgical Step by Step: Medial-Proximal Surface of Tibia Metaphysis
Follow-up and Termination
Recommendations
Intraoral: Description of the Procedures
Animal Welfare, Preparation for Survival Surgery and Anesthesia (General, Local)
Surgical Step-by-Step: Rat
Surgical Step-by-Step: Mouse
Follow-Up and Termination
Recommendations
2.3 Investigative Methods of Evaluation
2.3.1 X-Rays
2.3.2 Micro-CT
2.3.3 Histology (Remove Implant or Not)
2.3.4 Optics and Electronic Histology-Histomorphometry (Including Immunohistolabeling)
2.3.5 Biomechanics
2.3.5.1 Push-in Test
2.3.5.2 Pull-Out Test
2.3.6 Bacteriology
2.3.7 Genomics
2.4 Flag Ship Results from the Literature Using These Experimental-Surgical Models (Outlining Your Own Results): Critical Mini-Review
2.5 Expert Opinion: Balancing Models (Experimental and Surgical) Validation and Validity
References
3: Preclinical Studies Design and Place of Rabbits
3.1 Experimental Animal Model
3.1.1 Animal Species: Naturally-Occurring, Purpose-Bred and/or Genetically Modified
3.1.1.1 Animal Welfare
3.1.1.2 Handling and Husbandry
3.1.1.3 Health Status
3.1.2 General Use in Medical Devices Research
3.1.3 Financial Considerations
3.2 Surgical Model: Surgical Anatomical Site and Surgical Procedures for Implant Dentistry
3.2.1 Surgical Locations, Anatomy, and Histology
3.2.1.1 General Anatomical Information
3.2.1.2 Extraoral
Femur and Tibia
Skull
3.2.1.3 Intra Oral
Maxilla and Mandible
Sinuses
Foreword
Contents
1: The Method Sets the Tone
1.1 Introduction
1.2 The Heroes
1.3 The Endless Revolution
1.3.1 The Hypothesis
1.3.2 The Design
1.3.3 Evidence-Based Dentistry
1.4 Conclusion
References
Evidence-Based Dentistry Related References
2: Preclinical Studies Design and Place of Rodents
2.1 Experimental Animal Model
2.1.1 Animal Species: Naturally-Occurring, Purpose-Bread, and/or Genetically Modified
2.1.2 General Use in Medical Devices Research
2.1.3 Financial Considerations
2.2 Surgical Model
2.2.1 Surgical Anatomical Site and Surgical Procedures for Implant Dentistry
2.2.1.1 Surgical Locations
Extraoral
Anatomy and Histology
Function and Physiology (Movement, Loading)
Advantages/Inconveniences in Implant Dentistry
Recommendations
Intraoral
Anatomy and Histology
Function and Physiology (Movement, Loading, and Occlusion)
Advantages/Inconveniences in Implant Dentistry Anatomy and Histology
Recommendations
2.2.1.2 Surgical Procedures
Extraoral: Description of the Procedures
Animal Welfare, Preparation for Survival Surgery, and Anesthesia (General, Local)
Surgical Step by Step: Anterior-Distal Surface of Femur Metaphysis
Surgical Step-by-Step:Femoral Condyle
Surgical Step by Step: Medial-Proximal Surface of Tibia Metaphysis
Follow-up and Termination
Recommendations
Intraoral: Description of the Procedures
Animal Welfare, Preparation for Survival Surgery and Anesthesia (General, Local)
Surgical Step-by-Step: Rat
Surgical Step-by-Step: Mouse
Follow-Up and Termination
Recommendations
2.3 Investigative Methods of Evaluation
2.3.1 X-Rays
2.3.2 Micro-CT
2.3.3 Histology (Remove Implant or Not)
2.3.4 Optics and Electronic Histology-Histomorphometry (Including Immunohistolabeling)
2.3.5 Biomechanics
2.3.5.1 Push-in Test
2.3.5.2 Pull-Out Test
2.3.6 Bacteriology
2.3.7 Genomics
2.4 Flag Ship Results from the Literature Using These Experimental-Surgical Models (Outlining Your Own Results): Critical Mini-Review
2.5 Expert Opinion: Balancing Models (Experimental and Surgical) Validation and Validity
References
3: Preclinical Studies Design and Place of Rabbits
3.1 Experimental Animal Model
3.1.1 Animal Species: Naturally-Occurring, Purpose-Bred and/or Genetically Modified
3.1.1.1 Animal Welfare
3.1.1.2 Handling and Husbandry
3.1.1.3 Health Status
3.1.2 General Use in Medical Devices Research
3.1.3 Financial Considerations
3.2 Surgical Model: Surgical Anatomical Site and Surgical Procedures for Implant Dentistry
3.2.1 Surgical Locations, Anatomy, and Histology
3.2.1.1 General Anatomical Information
3.2.1.2 Extraoral
Femur and Tibia
Skull
3.2.1.3 Intra Oral
Maxilla and Mandible
Sinuses