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Table of Contents
Intro
Preface
Contents
Biological Methods for Drug Delivery
1 Introduction
2 Biological Barriers to Drug Delivery
3 Biological Methods for Drug Delivery
3.1 Endogenous Cell Membranes Vectors
3.2 Exogenous Substances: Viruses, VLPs and Virosomes
3.3 Extracellular Vesicles
4 BNPs Production Methods
4.1 Synthesis of Cell Membrane-Based BNPs
4.2 Synthesis of Exogenous Substances (Viruses, VLPs and Virosomes) Based BNPs
4.3 Synthesis of Extracellular Vesicles-Based BNPs
5 Clinical Trials of Biomimetic Nanoparticles
6 Challenges and Future Directions
7 Conclusion
References
Liposome-Based Drug Delivery-A New Therapeutic Paradigm
1 Introduction
2 Synthesis Techniques
2.1 Physical Methods
2.2 Chemical Methods
2.3 Characterization of Synthesized Liposomes
3 Infectious Diseases
3.1 Overview of Liposomal Drug Delivery for Infectious Diseases
3.2 Recent Technologies and Advances with Liposomal Drug Delivery
4 Mycobacterial Infections
4.1 Overview of Mycobacterial Infections
4.2 Clinical Studies on Liposomal Drug Delivery for Mycobacterial Infectious
5 Anticancer Drug Delivery
5.1 Overview of Anticancer Drug Delivery
5.2 Examples of Anticancer Drugs Used in Targeted Liposomal Drug Delivery
5.3 Challenges of Liposomal Delivery of Anticancer Drugs
5.4 Future Directions of Research on Liposomal Targeted Drug Delivery of Anticancer Drugs
6 Lung Specific Drug Delivery
7 Future Prospects
8 Conclusion
References
Multifunctional Liposomes to Attain Targeting, Stimuli Sensitive Drug Release and Imaging Cancer
1 Introduction
2 Structure of Liposomes
3 Liposomes in Cancer
4 Methods for the Preparation of Liposomes
4.1 Thin Film Hydration Process
4.2 Solvent Injection Process
4.3 Reverse Phase Evaporation Method
4.4 Detergent Removal Method
4.5 Size Reduction Method
5 Marketed Liposomal Formulation
6 Dual or Multi Drug Loaded Liposomes
7 Prolongation of Systemic Circulation of Liposomes
8 Strategies for Targeting Liposomes
9 Stimuli Sensitive Drug Delivery by Liposomes
10 Imaging of Cancer Using Liposomes
11 Cell Penetrating Liposomes
12 Multifunctional Liposomes
13 Clinical Trials Using Liposomal Formulations
14 Applications of Liposomes in Healthcare
15 Conclusion
References
Electroporation-Based Drug Delivery
1 Introduction
2 Mechanisms
3 Bulk Electroporation (BEP)
4 Single-Cell Electroporation (SCEP)
5 Localized Single-Cell Electroporation (LSCEP)
6 Clinical Trials
7 Pros and Cons of Electroporation
8 Concluding Remarks and Future Aspect
References
Mechanoporation-Based Drug Delivery
1 Introduction
2 Basic Mechanism
3 Different Methods of Mechanoporation
4 Device Fabrication
5 Advantages of Mechanoporation
6 Drawbacks of Mechanoporation
7 Conclusions
References
Preface
Contents
Biological Methods for Drug Delivery
1 Introduction
2 Biological Barriers to Drug Delivery
3 Biological Methods for Drug Delivery
3.1 Endogenous Cell Membranes Vectors
3.2 Exogenous Substances: Viruses, VLPs and Virosomes
3.3 Extracellular Vesicles
4 BNPs Production Methods
4.1 Synthesis of Cell Membrane-Based BNPs
4.2 Synthesis of Exogenous Substances (Viruses, VLPs and Virosomes) Based BNPs
4.3 Synthesis of Extracellular Vesicles-Based BNPs
5 Clinical Trials of Biomimetic Nanoparticles
6 Challenges and Future Directions
7 Conclusion
References
Liposome-Based Drug Delivery-A New Therapeutic Paradigm
1 Introduction
2 Synthesis Techniques
2.1 Physical Methods
2.2 Chemical Methods
2.3 Characterization of Synthesized Liposomes
3 Infectious Diseases
3.1 Overview of Liposomal Drug Delivery for Infectious Diseases
3.2 Recent Technologies and Advances with Liposomal Drug Delivery
4 Mycobacterial Infections
4.1 Overview of Mycobacterial Infections
4.2 Clinical Studies on Liposomal Drug Delivery for Mycobacterial Infectious
5 Anticancer Drug Delivery
5.1 Overview of Anticancer Drug Delivery
5.2 Examples of Anticancer Drugs Used in Targeted Liposomal Drug Delivery
5.3 Challenges of Liposomal Delivery of Anticancer Drugs
5.4 Future Directions of Research on Liposomal Targeted Drug Delivery of Anticancer Drugs
6 Lung Specific Drug Delivery
7 Future Prospects
8 Conclusion
References
Multifunctional Liposomes to Attain Targeting, Stimuli Sensitive Drug Release and Imaging Cancer
1 Introduction
2 Structure of Liposomes
3 Liposomes in Cancer
4 Methods for the Preparation of Liposomes
4.1 Thin Film Hydration Process
4.2 Solvent Injection Process
4.3 Reverse Phase Evaporation Method
4.4 Detergent Removal Method
4.5 Size Reduction Method
5 Marketed Liposomal Formulation
6 Dual or Multi Drug Loaded Liposomes
7 Prolongation of Systemic Circulation of Liposomes
8 Strategies for Targeting Liposomes
9 Stimuli Sensitive Drug Delivery by Liposomes
10 Imaging of Cancer Using Liposomes
11 Cell Penetrating Liposomes
12 Multifunctional Liposomes
13 Clinical Trials Using Liposomal Formulations
14 Applications of Liposomes in Healthcare
15 Conclusion
References
Electroporation-Based Drug Delivery
1 Introduction
2 Mechanisms
3 Bulk Electroporation (BEP)
4 Single-Cell Electroporation (SCEP)
5 Localized Single-Cell Electroporation (LSCEP)
6 Clinical Trials
7 Pros and Cons of Electroporation
8 Concluding Remarks and Future Aspect
References
Mechanoporation-Based Drug Delivery
1 Introduction
2 Basic Mechanism
3 Different Methods of Mechanoporation
4 Device Fabrication
5 Advantages of Mechanoporation
6 Drawbacks of Mechanoporation
7 Conclusions
References