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Intro
Preface
Contents
About the Editors
PPPM Innovation in Primary, Secondary and Tertiary Care
1 Health-to-Disease Transition in Focus of Advanced Bio/Medical Sciences and Healthcare Services
2 A Holistic Approach by 3P Medicine Is the Clue
3 Technological Innovation
4 Conclusion
References
Suboptimal Health Innovation: From Bench to Bedside
1 Introduction
2 Suboptimal Health Status
3 Diagnostic Tools for SHS
3.1 Subjective Measure
3.2 Objective Measurements Enhance the Reliability of SHSQ-25

4 Paradigm Shift from Reactive to Predictive, Preventive, and Personalized Medicine
5 Conclusion and Recommendations
Appendix 1: SHSQ-25
English Version
Chinese Version
Russian Version
Korean Version
References
What Is the Routine Mitochondrial Health Check-Up Good For? A Holistic Approach in the Framework of 3P Medicine
1 By Regulating Whole-Body Physiological Functions, Mitochondria Are at the "Forefront" of Holistic PPPM Approach
1.1 Mitochondrial Dynamics and Circadian Rhythmicity
1.2 Shift Work
1.3 Chronic Stress, Fatigue and Mitochondrial Burnout

2 Microvascular Deficits and Silent Lacunar Brain Lesions in Flammer Syndrome: A Case Presentation for Implementing PPPM Strategies
3 Compromised Mitochondrial Health in Critical Illnesses: Prominent Examples
3.1 Mitochondrial Dysfunction in the Ageing-Related Metabolic Disorders
3.2 Female and Male Reproductive Health
3.3 Pathologic Pregnancy
3.4 Connective Tissue Dysregulation
3.5 Atrial Fibrillation (AF)
3.6 Ischemic Stroke
3.7 Skin Disorders
3.7.1 Atopic Dermatitis (AD, Also Atopic Eczema/Neurodermitis)
3.8 Impaired Wound Healing
3.9 Cancers

3.10 Sleep Disorders
3.11 Psychiatric Disorders
3.12 Endocrine Disorders
3.13 Kidney Disease
3.14 Liver Disorders
3.15 Eye Disorders
3.15.1 Retinal Microvascular Endothelial Cells Dysfunction
3.15.2 Myopia
3.15.3 Glaucoma
3.15.4 Diabetic Retinopathy
3.15.5 Early Cataract
3.16 Neurodegeneration
3.17 Musculoskeletal Degenerative Disorders
3.18 Respiratory Diseases
3.19 Long COVID
4 Conclusions and Outlook in the Framework of 3P Medicine
References

Prehabilitation as an Integral Procedure in Predictive, Preventive, and Personalized Medicine and Modern and Effective Healthcare
1 Introduction
1.1 History of Prehabilitation
2 Prehabilitation
2.1 Multimodal Approach of Prehabilitation
2.1.1 The Reason for Multimodal Approach in Prehabilitation
2.2 Exercise and Physical Activity (Rehabilitation) as Element of Prehabilitation
2.2.1 Patient Examination and Setting Up Training in Terms of Prehabilitation
2.2.2 6-Minute Walk Test
2.2.3 Chair Stand Test
2.2.4 Timed Up-and-Go Test (TUG)

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