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001482821 019__ $$a1407278496
001482821 020__ $$a9783031351181$$q(electronic bk.)
001482821 020__ $$a3031351185$$q(electronic bk.)
001482821 020__ $$z3031351177
001482821 020__ $$z9783031351174
001482821 0247_ $$a10.1007/978-3-031-35118-1$$2doi
001482821 035__ $$aSP(OCoLC)1407313194
001482821 040__ $$aEBLCP$$beng$$cEBLCP$$dOCLCO$$dGW5XE$$dYDX
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001482821 050_4 $$aRB113$$b.M65 2023eb
001482821 08204 $$a571.9/4$$223/eng/20231116
001482821 24500 $$aMolecular surgical pathology /$$cLiang Cheng, George J. Netto, John N. Eble, editors.
001482821 250__ $$a2nd ed.
001482821 260__ $$aCham :$$bSpringer,$$c2023.
001482821 300__ $$a1 online resource (725 p.)
001482821 500__ $$aDigital Pathology (DP)
001482821 500__ $$aIncludes index.
001482821 5050_ $$aIntro -- Preface -- Contents -- Contributors -- 1: Molecular Techniques/Molecular Diagnostics for Surgical Pathologists: An Overview -- Introduction -- Roles for Molecular Surgical Pathology -- Background Information for Molecular Genomics -- Background on Genome Organization -- DNA Sequence Variation -- Background for RNA Analysis -- Overview of Molecular Methods -- Sample Preparation -- Sample Types -- Sample Adequacy -- Fixatives -- DNA/RNA Extraction Basic Steps -- Preparation of DNA from Formalin Fixed Paraffin Embedded Tissue -- DNA Methylation -- RNA Extraction
001482821 5058_ $$aQuality Assessment of DNA and RNA -- Cytogenetics -- Background Information for Cytogenetics -- Classes of Pathogenic Cytogenetic Variation -- Cytogenetic Methods -- Karyotyping -- Fluorescent In Situ Hybridization -- Microarrays -- Molecular Diagnostics Basic Methods -- DNA/RNA Electrophoresis -- The Art of Detection -- Target Amplification Versus Signal Amplification -- Methods: PCR -- Principles of PCR -- Real-Time PCR -- PCR Contamination -- Real-Time PCR Formats -- SNV Detection by PCR -- Methods: Digital Droplet PCR (ddPCR) -- Methods: Rolling Circle Amplification (RCA)
001482821 5058_ $$aMethods: Hybridization Chain Reaction (HCR) -- Methods: Branched DNA (bDNA) -- Methods: Whole-Genome Amplification (WGA) -- Sequencing -- General Remarks -- Methods: Sequencing/Sanger Sequencing -- Second-Generation Sequencing -- Second Generation Sequencing Platforms -- Outline of a Representative Illumina Protocol -- Outline of a Representative Thermo-Fisher (Ion Torrent) Protocol -- Third-Generation Sequencing -- PacBio -- Oxford Nanoporetech -- Other Applications of NGS -- Bioinformatics -- Single-Cell 'Omics' -- General Remarks -- Single-Cell Protocols
001482821 5058_ $$aSpatial 'Omics: Not Quite the Final Frontier -- General Remarks -- In Situ Hybridization (ISH) -- Single Molecule FISH (smFISH) -- Representative Method: SeqFISH+ -- Representative Method: MERFISH -- In Situ Sequencing -- In Situ Capture-Ex Situ Sequencing (Generic) -- Representative Implementation: GeoMx Digital Space Profiler -- Representative Implementation: Seq-Scope Illumina -- Representative Implementation: HDST -- Representative Implementation: Visium (10× Genomics) -- In Situ Genomic (DNA) Sequencing Extended by Ex Situ Sequencing -- Analysis -- Achievements of Spatial Genomics
001482821 5058_ $$aFuture Directions/Predictions -- Further Reading -- 2: Bioinformatics, Digital Pathology, and Computational Pathology for Surgical Pathologists -- Introduction -- Bioinformatics, a Distinct Field in Pathology and Where Are We Now -- Pathology Bioinformaticians and Their Role -- Specialized Training in Bioinformatics -- Definitions and Terminologies Related to Bioinformatics and Computational Pathology -- Annotation -- Artificial Intelligence (AI) -- Black Box/Glass Box -- Cloud Computing -- Computational Pathology (CPATH) -- Convolutional Neural Network (CNN) -- Deep Learning -- Data Augmentation
001482821 506__ $$aAccess limited to authorized users.
001482821 520__ $$aSince the first edition of this book in 2012, the field of molecular pathology has expanded exponentially. The advent of complete cancer genome sequencing, new diagnostic molecular tests, and biomarkers for targeted therapy and immunotherapy have demonstrated the importance of molecular tools both in patient care and in the practice of pathology. Furthermore, the development of many new molecular technologies has revolutionized the practice of modern pathology. The rapid growth of this field has led to an expansion of knowledge of molecular processes and many more clinical applications in our daily practice of surgical pathology. Thus, this updated second edition of Molecular Surgical Pathology aims to serve as the best available quick reference for pathologists, oncologists, geneticists, primary care physicians, and other medical professionals with an interest in this specialty. Molecular Surgical Pathology 2nd Edition focuses on the practical utility of molecular techniques and on molecular biomarkers for the practicing surgical pathologist. The emphasis is on the impact of molecular pathology for tumor classification, diagnosis and differential diagnosis, as well as its implications for patient management and personalized care. This concise overview of molecular surgical pathology and molecular classification of tumors of different organ sites will help not only practicing physicians, but also those in training, including residents and fellows in various disciplines.
001482821 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed November 16, 2023).
001482821 650_0 $$aPathology, Molecular.$$0(DLC)sh 85098691
001482821 650_0 $$aPathology, Surgical.
001482821 655_0 $$aElectronic books.
001482821 7001_ $$aCheng, Liang.$$d1901-1972$$0(OCoLC)oca00784400
001482821 7001_ $$aNetto, George J.
001482821 7001_ $$aEble, John N.
001482821 77608 $$iPrint version:$$aCheng, Liang$$tMolecular Surgical Pathology$$dCham : Springer International Publishing AG,c2023$$z9783031351174
001482821 852__ $$bebk
001482821 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-35118-1$$zOnline Access$$91397441.1
001482821 909CO $$ooai:library.usi.edu:1482821$$pGLOBAL_SET
001482821 980__ $$aBIB
001482821 980__ $$aEBOOK
001482821 982__ $$aEbook
001482821 983__ $$aOnline
001482821 994__ $$a92$$bISE