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Table of Contents
Intro
Preface
Contents
About the Authors
1: Introduction to Pulmonary Diseases and OMICS Approaches
1.1 Pulmonary Diseases
1.2 Types of Pulmonary Diseases
1.3 Need and Significance of Biomarkers in Pulmonary Diseases
Diagnostic Biomarkers
Monitoring Biomarkers
Prognostic Biomarkers
Risk or Susceptibility Biomarkers
Pharmacodynamic or Drug Response Biomarkers
Predictive Biomarkers
1.4 Omics Approaches as Tools for Identification of Biomarkers for Pulmonary Diseases
1.5 Types of Omics Approaches
Genomics
Epigenomics
Transcriptomics
Proteomics
Metabolomics
Exposomics
Metagenomics
Radiomics
Bioinformatics
Integrative Omics
1.6 Different Biological Samples Explored by Omics Approaches for Discovery of Biomarkers for Pulmonary Diseases
Blood
Sputum
Exhaled Breath
Urine
Broncho Alveolar Lavage Fluid (BALF)
Bronchial Tissue Biopsies
1.7 Conclusion
References
2: Obstructive Airway Diseases
2.1 Introduction
2.2 Clinical Features
2.3 Different Types of Obstructive Pulmonary Diseases
2.4 Diagnosis of Obstructive Pulmonary Diseases
Pulmonary Function Tests (PFTs)
6-min Walk Test & 2-Chair Test
Imaging Techniques
2.5 Treatment of Obstructive Pulmonary Diseases
2.6 Dissecting Different Dimensions of Obstructive Pulmonary Diseases: A Step Toward Precision Medicine
2.7 Conclusion
References
3: Chronic Obstructive Pulmonary Disease (COPD)
3.1 Introduction
3.2 Clinical Features
3.3 Biomarkers of COPD
3.4 Genomics
3.5 Epigenomics
3.6 Transcriptomics
3.7 Proteomics
3.8 Metabolomics
3.9 Metagenomics
3.10 Medical Imaging or Radiomics
3.11 Bioinformatics
3.12 Multi-Omics and Data Integration
3.13 Current Applications
3.14 Future Perspectives
References
4: Asthma
4.1 Introduction
4.2 Clinical Features
Classification of Asthma
4.3 Biomarkers of Asthma
4.4 Genomics
4.5 Epigenomics
4.6 Transcriptomics
4.7 Proteomics
4.8 Metabolomics
4.9 Metagenomics
4.10 Exposomics
4.11 Bioinformatics
4.12 Medical Imaging
4.13 Multi-omics and Data Integration
4.14 Current Applications
4.15 Future Perspectives
References
5: Bronchiectasis
5.1 Introduction
5.2 Pathobiology
5.3 Clinical Features and Diagnosis
5.4 Biomarkers of Bronchiectasis
5.5 Genomics
5.6 Transcriptomics
5.7 Proteomics
5.8 Metabolomics
5.9 Metagenomics
5.10 Bioinformatics
5.11 Medical Imaging or Radiomics
5.12 Multi-Omics and Data Integration
5.13 Present Therapeutic Strategies
5.14 Future Perspectives
References
6: Restrictive Pulmonary Diseases
6.1 Introduction
6.2 Clinical Features
6.3 Aetiology and Pathogenesis
6.4 Different Types of Restrictive Pulmonary Diseases
6.5 Diagnosis of Restrictive Pulmonary Diseases
6.6 Treatment of Restrictive Pulmonary Diseases
Preface
Contents
About the Authors
1: Introduction to Pulmonary Diseases and OMICS Approaches
1.1 Pulmonary Diseases
1.2 Types of Pulmonary Diseases
1.3 Need and Significance of Biomarkers in Pulmonary Diseases
Diagnostic Biomarkers
Monitoring Biomarkers
Prognostic Biomarkers
Risk or Susceptibility Biomarkers
Pharmacodynamic or Drug Response Biomarkers
Predictive Biomarkers
1.4 Omics Approaches as Tools for Identification of Biomarkers for Pulmonary Diseases
1.5 Types of Omics Approaches
Genomics
Epigenomics
Transcriptomics
Proteomics
Metabolomics
Exposomics
Metagenomics
Radiomics
Bioinformatics
Integrative Omics
1.6 Different Biological Samples Explored by Omics Approaches for Discovery of Biomarkers for Pulmonary Diseases
Blood
Sputum
Exhaled Breath
Urine
Broncho Alveolar Lavage Fluid (BALF)
Bronchial Tissue Biopsies
1.7 Conclusion
References
2: Obstructive Airway Diseases
2.1 Introduction
2.2 Clinical Features
2.3 Different Types of Obstructive Pulmonary Diseases
2.4 Diagnosis of Obstructive Pulmonary Diseases
Pulmonary Function Tests (PFTs)
6-min Walk Test & 2-Chair Test
Imaging Techniques
2.5 Treatment of Obstructive Pulmonary Diseases
2.6 Dissecting Different Dimensions of Obstructive Pulmonary Diseases: A Step Toward Precision Medicine
2.7 Conclusion
References
3: Chronic Obstructive Pulmonary Disease (COPD)
3.1 Introduction
3.2 Clinical Features
3.3 Biomarkers of COPD
3.4 Genomics
3.5 Epigenomics
3.6 Transcriptomics
3.7 Proteomics
3.8 Metabolomics
3.9 Metagenomics
3.10 Medical Imaging or Radiomics
3.11 Bioinformatics
3.12 Multi-Omics and Data Integration
3.13 Current Applications
3.14 Future Perspectives
References
4: Asthma
4.1 Introduction
4.2 Clinical Features
Classification of Asthma
4.3 Biomarkers of Asthma
4.4 Genomics
4.5 Epigenomics
4.6 Transcriptomics
4.7 Proteomics
4.8 Metabolomics
4.9 Metagenomics
4.10 Exposomics
4.11 Bioinformatics
4.12 Medical Imaging
4.13 Multi-omics and Data Integration
4.14 Current Applications
4.15 Future Perspectives
References
5: Bronchiectasis
5.1 Introduction
5.2 Pathobiology
5.3 Clinical Features and Diagnosis
5.4 Biomarkers of Bronchiectasis
5.5 Genomics
5.6 Transcriptomics
5.7 Proteomics
5.8 Metabolomics
5.9 Metagenomics
5.10 Bioinformatics
5.11 Medical Imaging or Radiomics
5.12 Multi-Omics and Data Integration
5.13 Present Therapeutic Strategies
5.14 Future Perspectives
References
6: Restrictive Pulmonary Diseases
6.1 Introduction
6.2 Clinical Features
6.3 Aetiology and Pathogenesis
6.4 Different Types of Restrictive Pulmonary Diseases
6.5 Diagnosis of Restrictive Pulmonary Diseases
6.6 Treatment of Restrictive Pulmonary Diseases