The marathon of the messenger : a history of messenger RNA vaccines / Jérôme Lemonnier and Nicolas Lemonnier ; drawings by Gilles Charrot.
Lemonnier, Jérôme, author.; Lemonnier, Nicolas, author.; Charrot, Gilles, illustrator.
2023
QR189.2
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Title The marathon of the messenger : a history of messenger RNA vaccines / Jérôme Lemonnier and Nicolas Lemonnier ; drawings by Gilles Charrot.
Author Lemonnier, Jérôme, author.
ISBN 9783031393006 (electronic bk.)
3031393007 (electronic bk.)
9783031392993
303139299X
DOI https://doi.org/10.1007/978-3-031-39300-6
Published Cham : Springer, [2023]
Language English
Description 1 online resource (172 pages) : illustrations (black and white, and colour).
Other Standard Identifiers 10.1007/978-3-031-39300-6 doi
Call Number QR189.2
Dewey Decimal Classification 615.19
Summary The Covid-19 pandemic changed the world. Indeed a real race took place worldwide between SARS-CoV-2 on the one hand and researchers on the other especially those specializing in messenger RNA vaccines. Four years after its emergence, the pandemic is not over, but some decisive battles have been won, thanks to the great success of mRNA vaccines. The Marathon of The Messenger presents the history of these mRNA vaccines, combining a scientific background with historical and economic perspectives. It appears that an important page in the history of these new vaccines was written in Europe, thanks to the crucial work of German and French scientists; this effort began in 1993 and continues to this day. In the face of a prevailing single-mindedness, these researchers pushed through a new therapeutic concept and defined the biotechnological keys that would open the way to the production of therapeutic messenger RNA in the fight against cancer and viral infections. Written for a broad audience and accompanied by humorous cartoons, this book will appeal to anyone looking for scientific and historical answers about mRNA vaccines. Readers will discover not only the technical and scientific knowledge of how these vaccines work, but also the economic levers that were necessary to create this technology. This book has been written in collaboration with Dr. Steve Pascolo, former director of CureVac, and the RNA messenger expert Professor Chantal Pichon. It also features a preface by Dr. Pierre Meulien, former director of the European Union public-private partnership Innovative Medicines Initiative (IMI). This book is a translation of an original French edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Source of Description Description based on print version record.
Added Author Lemonnier, Nicolas, author.
Charrot, Gilles, illustrator.
Available in Other Form Marathon of the messenger.
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Intro
About the Authors
Acknowledgements
Contents
Foreword
Preface
Introduction: The Marathon of the Messenger RNA...
Part I Messenger RNA, An Essential Role and Challenge
1 A Short History of Vaccination
References
2 From DNA to RNA
2.1 The Skeleton of DNA and RNA
References
3 Messenger RNA (mRNA): From Transcription to Protein Translation
4 The Mechanism of Viral Infection
4.1 The AIDS Virus and New Viruses
5 The Immune Response
5.1 The Role of Cytokines
5.2 Facilitating Antibodies
References

Part II From Preliminary Studies to Clinical Trials
6 Promising Studies in the 1990s
References
7 The Use of mRNA-The Initial Technical Obstacles
References
8 The Birth of CureVac: The Era of the Pioneers
References
9 Solutions for mRNA Optimization
References
10 Modified and Unmodified mRNA: For What Purpose?
References
11 Experiments and Clinical Trials Conducted: The Power of Therapeutic mRNA
References
12 Experiments and Clinical Trials Against Infectious Diseases
12.1 The Role of Type 1 Interferon in Triggering the Adaptive Immune Response

18 The Importance of Intellectual Property and Patents
References
19 2020: The Triumph of Anti-Covid mRNA Vaccines
19.1 Additional Data on Anti-Covid mRNA Vaccines
References
20 mRNA, a Technology of the Future
References
Conclusion
Postfaces
Afterword by Chantal Pichon
Afterword by Steve Pascolo
Glossary

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