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001483934 001__ 1483934
001483934 003__ OCoLC
001483934 005__ 20240117003308.0
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001483934 008__ 231108s2023\\\\sz\a\\\\ob\\\\000\0\eng\d
001483934 019__ $$a1407278595$$a1407316541
001483934 020__ $$a9783031393006$$q(electronic bk.)
001483934 020__ $$a3031393007$$q(electronic bk.)
001483934 020__ $$z9783031392993
001483934 020__ $$z303139299X
001483934 0247_ $$a10.1007/978-3-031-39300-6$$2doi
001483934 035__ $$aSP(OCoLC)1408384212
001483934 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dN$T$$dOCLCO$$dGW5XE$$dEBLCP$$dYDX$$dOCLCQ
001483934 049__ $$aISEA
001483934 050_4 $$aQR189.2
001483934 08204 $$a615.19$$223/eng/20231116
001483934 1001_ $$aLemonnier, Jérôme,$$eauthor.
001483934 24514 $$aThe marathon of the messenger :$$ba history of messenger RNA vaccines /$$cJérôme Lemonnier and Nicolas Lemonnier ; drawings by Gilles Charrot.
001483934 264_1 $$aCham :$$bSpringer,$$c[2023]
001483934 300__ $$a1 online resource (172 pages) :$$billustrations (black and white, and colour).
001483934 336__ $$atext$$btxt$$2rdacontent
001483934 337__ $$acomputer$$bc$$2rdamedia
001483934 338__ $$aonline resource$$bcr$$2rdacarrier
001483934 504__ $$aIncludes bibliographical references.
001483934 5050_ $$aIntro -- About the Authors -- Acknowledgements -- Contents -- Foreword -- Preface -- Introduction: The Marathon of the Messenger RNA... -- Part I Messenger RNA, An Essential Role and Challenge -- 1 A Short History of Vaccination -- References -- 2 From DNA to RNA -- 2.1 The Skeleton of DNA and RNA -- References -- 3 Messenger RNA (mRNA): From Transcription to Protein Translation -- 4 The Mechanism of Viral Infection -- 4.1 The AIDS Virus and New Viruses -- 5 The Immune Response -- 5.1 The Role of Cytokines -- 5.2 Facilitating Antibodies -- References
001483934 5058_ $$aPart II From Preliminary Studies to Clinical Trials -- 6 Promising Studies in the 1990s -- References -- 7 The Use of mRNA-The Initial Technical Obstacles -- References -- 8 The Birth of CureVac: The Era of the Pioneers -- References -- 9 Solutions for mRNA Optimization -- References -- 10 Modified and Unmodified mRNA: For What Purpose? -- References -- 11 Experiments and Clinical Trials Conducted: The Power of Therapeutic mRNA -- References -- 12 Experiments and Clinical Trials Against Infectious Diseases -- 12.1 The Role of Type 1 Interferon in Triggering the Adaptive Immune Response
001483934 5058_ $$a18 The Importance of Intellectual Property and Patents -- References -- 19 2020: The Triumph of Anti-Covid mRNA Vaccines -- 19.1 Additional Data on Anti-Covid mRNA Vaccines -- References -- 20 mRNA, a Technology of the Future -- References -- Conclusion -- Postfaces -- Afterword by Chantal Pichon -- Afterword by Steve Pascolo -- Glossary
001483934 506__ $$aAccess limited to authorized users.
001483934 520__ $$aThe Covid-19 pandemic changed the world. Indeed a real race took place worldwide between SARS-CoV-2 on the one hand and researchers on the other especially those specializing in messenger RNA vaccines. Four years after its emergence, the pandemic is not over, but some decisive battles have been won, thanks to the great success of mRNA vaccines. The Marathon of The Messenger presents the history of these mRNA vaccines, combining a scientific background with historical and economic perspectives. It appears that an important page in the history of these new vaccines was written in Europe, thanks to the crucial work of German and French scientists; this effort began in 1993 and continues to this day. In the face of a prevailing single-mindedness, these researchers pushed through a new therapeutic concept and defined the biotechnological keys that would open the way to the production of therapeutic messenger RNA in the fight against cancer and viral infections. Written for a broad audience and accompanied by humorous cartoons, this book will appeal to anyone looking for scientific and historical answers about mRNA vaccines. Readers will discover not only the technical and scientific knowledge of how these vaccines work, but also the economic levers that were necessary to create this technology. This book has been written in collaboration with Dr. Steve Pascolo, former director of CureVac, and the RNA messenger expert Professor Chantal Pichon. It also features a preface by Dr. Pierre Meulien, former director of the European Union public-private partnership Innovative Medicines Initiative (IMI). This book is a translation of an original French edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation.
001483934 588__ $$aDescription based on print version record.
001483934 650_0 $$amRNA vaccines$$xHistory.
001483934 650_6 $$aVaccins à ARN messager$$xHistoire.
001483934 655_0 $$aElectronic books.
001483934 7001_ $$aLemonnier, Nicolas,$$eauthor.
001483934 7001_ $$aCharrot, Gilles,$$eillustrator.
001483934 77608 $$iPrint version:$$aLemonnier, Jérôme.$$tMarathon of the messenger.$$dCham : Springer, 2023$$z9783031392993$$w(OCoLC)1400087069
001483934 852__ $$bebk
001483934 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-39300-6$$zOnline Access$$91397441.1
001483934 909CO $$ooai:library.usi.edu:1483934$$pGLOBAL_SET
001483934 980__ $$aBIB
001483934 980__ $$aEBOOK
001483934 982__ $$aEbook
001483934 983__ $$aOnline
001483934 994__ $$a92$$bISE