Role of signaling pathways in brain tumoriogenesis / Mehdi Hayat Shahi.
Shahi, Mehdi Hayat, author.
2023
RC280.B7
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Title
Role of signaling pathways in brain tumoriogenesis / Mehdi Hayat Shahi.
Author
Shahi, Mehdi Hayat, author.
ISBN
9789811584732 (electronic bk.)
9811584737 (electronic bk.)
9789811584725
9811584729
DOI
https://doi.org/10.1007/978-981-15-8473-2
Published
Singapore : Springer, 2023.
Language
English
Description
1 online resource
Item Number
10.1007/978-981-15-8473-2 doi
Call Number
RC280.B7
Dewey Decimal Classification
616.99481
Summary
This book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. Finally, the book summarizes the potential early therapeutic targets and targeted drug discovery for brain tumours. .
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Access limited to authorized users.
Source of Description
Description based on print version record.
Available in Other Form
Print version: 9811584729
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Intro
Preface
Organization of the Book
Acknowledgments
Contents
About the Author
Part I
1: Introduction to Cell Signaling Pathways and Brain Tumors
1.1 Cell-Signaling Pathway Classification
1.1.1 Endocrine Signaling
1.1.2 Autocrine Signaling
1.1.3 Paracrine Signaling
1.1.4 Intracrine Signaling
1.1.5 Juxtacrine Signaling
1.2 Introduction to Brain Tumors
1.2.1 Primary Brain Tumors
1.2.2 Brain Tumor Metastases
1.2.3 Benign Brain Tumors
1.2.4 Malignant Brain Tumors
1.2.4.1 Astrocytoma
1.2.4.2 Ependymoma

1.2.4.3 Glioblastoma
1.2.4.4 Oligodendroglioma
1.2.4.5 Medulloblastoma
1.2.5 Symptoms
References
Part II
2: Wnt Cell Signaling Pathway in Brain Tumor Development
2.1 Canonical Pathway
References
3: Notch Cell Signaling Pathway and Brain Tumors
References
4: Sonic Hedgehog Cell Signaling Pathway and Medulloblastoma
References
5: Role of the Shh Signaling Pathway in the Most Common Brain Tumor "Glioma" role in Glioma Growth
References
Part III
6: NANOG Stem Cell Marker and Its Role in Brain Tumor Development
References

7: Stem Cell Factor Sox2 and Brain Tumor Development
References
8: Role of Neurotrophins in Brain Tumor Development
8.1 Role of Neurotrophins in Neuron Development
8.2 NGF and Brain Tumors
8.3 BDNF and Brain Tumor
8.4 NT3 and Brain Tumors
8.5 NT-4 and Brain Tumors
8.6 Dehydroepiandrosterone (DHEA) and Brain Tumor
References
9: Role of NF-kB in Brain Tumor Development
References
Part IV
10: Role of Myc in Brain Tumor Development
References
11: Role of p53 in Medulloblastoma Development
References
12: Role of TP53 Gene in Glioma
References

13: Role of HIF-1 in Brain Tumor Development
References
Part V
14: EGFR and Its Role in Glioma Development
References
15: Role of EFGR in Medulloblastoma Development
References
16: Role of OCT4 in Glioblastoma
References
Part VI
17: Role of OCT4 in Pediatric Brain Tumor "Medulloblastoma" Development
References
18: Mitogen-activated protein (MAP) kinase Roles in Paediatric Brain Tumor "Medulloblastoma"
References

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