001484236 000__ 04966cam\\2200553\i\4500
001484236 001__ 1484236
001484236 003__ OCoLC
001484236 005__ 20240117003317.0
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001484236 008__ 231124s2023\\\\si\a\\\\o\\\\\000\0\eng\d
001484236 019__ $$a1410591456
001484236 020__ $$a9789811584732$$q(electronic bk.)
001484236 020__ $$a9811584737$$q(electronic bk.)
001484236 020__ $$z9789811584725
001484236 020__ $$z9811584729
001484236 0247_ $$a10.1007/978-981-15-8473-2$$2doi
001484236 035__ $$aSP(OCoLC)1410432961
001484236 040__ $$aYDX$$beng$$cYDX$$dOCLCO$$dGW5XE$$dEBLCP$$dOCLCO
001484236 049__ $$aISEA
001484236 050_4 $$aRC280.B7
001484236 08204 $$a616.99481$$223/eng/20231211
001484236 1001_ $$aShahi, Mehdi Hayat,$$eauthor.
001484236 24510 $$aRole of signaling pathways in brain tumoriogenesis /$$cMehdi Hayat Shahi.
001484236 264_1 $$aSingapore :$$bSpringer,$$c2023.
001484236 300__ $$a1 online resource
001484236 5050_ $$aIntro -- Preface -- Organization of the Book -- Acknowledgments -- Contents -- About the Author -- Part I -- 1: Introduction to Cell Signaling Pathways and Brain Tumors -- 1.1 Cell-Signaling Pathway Classification -- 1.1.1 Endocrine Signaling -- 1.1.2 Autocrine Signaling -- 1.1.3 Paracrine Signaling -- 1.1.4 Intracrine Signaling -- 1.1.5 Juxtacrine Signaling -- 1.2 Introduction to Brain Tumors -- 1.2.1 Primary Brain Tumors -- 1.2.2 Brain Tumor Metastases -- 1.2.3 Benign Brain Tumors -- 1.2.4 Malignant Brain Tumors -- 1.2.4.1 Astrocytoma -- 1.2.4.2 Ependymoma
001484236 5058_ $$a1.2.4.3 Glioblastoma -- 1.2.4.4 Oligodendroglioma -- 1.2.4.5 Medulloblastoma -- 1.2.5 Symptoms -- References -- Part II -- 2: Wnt Cell Signaling Pathway in Brain Tumor Development -- 2.1 Canonical Pathway -- References -- 3: Notch Cell Signaling Pathway and Brain Tumors -- References -- 4: Sonic Hedgehog Cell Signaling Pathway and Medulloblastoma -- References -- 5: Role of the Shh Signaling Pathway in the Most Common Brain Tumor "Glioma" role in Glioma Growth -- References -- Part III -- 6: NANOG Stem Cell Marker and Its Role in Brain Tumor Development -- References
001484236 5058_ $$a7: Stem Cell Factor Sox2 and Brain Tumor Development -- References -- 8: Role of Neurotrophins in Brain Tumor Development -- 8.1 Role of Neurotrophins in Neuron Development -- 8.2 NGF and Brain Tumors -- 8.3 BDNF and Brain Tumor -- 8.4 NT3 and Brain Tumors -- 8.5 NT-4 and Brain Tumors -- 8.6 Dehydroepiandrosterone (DHEA) and Brain Tumor -- References -- 9: Role of NF-kB in Brain Tumor Development -- References -- Part IV -- 10: Role of Myc in Brain Tumor Development -- References -- 11: Role of p53 in Medulloblastoma Development -- References -- 12: Role of TP53 Gene in Glioma -- References
001484236 5058_ $$a13: Role of HIF-1 in Brain Tumor Development -- References -- Part V -- 14: EGFR and Its Role in Glioma Development -- References -- 15: Role of EFGR in Medulloblastoma Development -- References -- 16: Role of OCT4 in Glioblastoma -- References -- Part VI -- 17: Role of OCT4 in Pediatric Brain Tumor "Medulloblastoma" Development -- References -- 18: Mitogen-activated protein (MAP) kinase Roles in Paediatric Brain Tumor "Medulloblastoma" -- References
001484236 506__ $$aAccess limited to authorized users.
001484236 520__ $$aThis book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. Finally, the book summarizes the potential early therapeutic targets and targeted drug discovery for brain tumours. .
001484236 588__ $$aDescription based on print version record.
001484236 650_6 $$aCerveau$$xTumeurs$$xPathogenèse.
001484236 650_6 $$aTransduction du signal cellulaire.
001484236 650_6 $$aCerveau$$xTumeurs$$xTraitement.
001484236 650_0 $$aBrain$$xTumors$$xPathogenesis.
001484236 650_0 $$aCellular signal transduction.$$0(DLC)sh 89002397
001484236 650_0 $$aBrain$$xTumors$$xTreatment.
001484236 655_0 $$aElectronic books.
001484236 77608 $$iPrint version: $$z9789811584725$$z9811584729$$w(OCoLC)1295105159
001484236 852__ $$bebk
001484236 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-981-15-8473-2$$zOnline Access$$91397441.1
001484236 909CO $$ooai:library.usi.edu:1484236$$pGLOBAL_SET
001484236 980__ $$aBIB
001484236 980__ $$aEBOOK
001484236 982__ $$aEbook
001484236 983__ $$aOnline
001484236 994__ $$a92$$bISE