001484264 000__ 05833cam\\22005657i\4500 001484264 001__ 1484264 001484264 003__ OCoLC 001484264 005__ 20240117003318.0 001484264 006__ m\\\\\o\\d\\\\\\\\ 001484264 007__ cr\cn\nnnunnun 001484264 008__ 231125s2023\\\\sz\\\\\\o\\\\\001\0\eng\d 001484264 019__ $$a1410592079 001484264 020__ $$a9783031365225$$qelectronic book 001484264 020__ $$a3031365224$$qelectronic book 001484264 020__ $$z3031365216 001484264 020__ $$z9783031365218 001484264 0247_ $$a10.1007/978-3-031-36522-5$$2doi 001484264 035__ $$aSP(OCoLC)1410561784 001484264 040__ $$aYDX$$beng$$erda$$cYDX$$dGW5XE$$dYDX$$dOCLCO$$dEBLCP 001484264 049__ $$aISEA 001484264 050_4 $$aRC391$$b.N67 2023 001484264 08204 $$a616.858843$$223/eng/20231211 001484264 24500 $$aNormal pressure hydrocephalus :$$bpathophysiology, diagnosis, treatment and outcome /$$cOndrej Bradac, editor. 001484264 264_1 $$aCham, Switzerland :$$bSpringer,$$c[2023] 001484264 300__ $$a1 online resource 001484264 336__ $$atext$$btxt$$2rdacontent 001484264 337__ $$acomputer$$bc$$2rdamedia 001484264 338__ $$aonline resource$$bcr$$2rdacarrier 001484264 500__ $$aIncludes index. 001484264 5050_ $$aIntro -- Foreword by Prof. Vladimír Benea-- Foreword by Prof. David Netuka -- Foreword by Assoc. Prof. Vladimír Benea Jr. -- Acknowledgements -- Contents -- History and Background -- Introduction -- 1 Why a Book About NPH? -- References -- History -- 1 Introduction -- 2 Hydrocephalus History -- 3 Hakim's Discovery of NPH -- 4 Fundamental Discoveries in the Last Decades -- 4.1 Pathophysiology -- 4.2 Diagnosis -- 4.3 Shunt Systems -- 5 Conclusion -- 6 Key Points -- References -- Modern Hydrocephalus Classification Systems -- 1 Introduction -- 2 Hydrocephalus Definition 001484264 5058_ $$a3 Treatment Strategies Based on HCP Type -- 4 Categories of HCP -- 4.1 Classification Based on Age of Onset -- 4.2 Classification Based on Underlying Cause -- 4.3 Classification Based on Symptomatology and Chronology -- 4.4 Classification Based on CSF Dynamics -- 4.5 Classification Based on Pressure Dynamics -- 4.6 Classification Based on Genetics -- 4.7 Current Multi-categorical Classification System -- 4.8 ASPECT Hydrocephalus System -- 5 Conclusion -- 6 Key Points -- References -- The Epidemiology of Normal Pressure Hydrocephalus -- 1 Introduction -- 2 Population-Based Studies 001484264 5058_ $$a2.1 Population-Based Studies Following the American-European Guidelines -- 2.2 Population-Based Studies Following the Japanese Guidelines -- 3 Hospital-Based Studies -- 4 Register Data Studies -- 5 Meta-analyses and Systematic Reviews -- 6 Other Epidemiological Studies -- 7 Clinical Relevance -- 8 Conclusion -- 9 Key Points -- References -- CSF Physiology -- 1 Introduction -- 2 A Brief Historical Insight -- 3 Anatomical Concept -- 3.1 Ventricular System and Central Canal -- 3.2 The Complexity of Barriers -- 4 CSF Composition -- 5 CSF Functions -- 6 CSF Mechanisms -- 6.1 Production and Secretion 001484264 5058_ $$a6.2 Classical Hypothesis and Its Criticism -- 6.3 Circulation and Dynamics -- 6.4 The Glymphatic System -- 6.5 Absorption -- 7 Conclusion -- 8 Key Points -- References -- Pathophysiology of NPH -- 1 Introduction -- 2 Historical Understanding of NPH Pathophysiology -- 3 Alteration of CSF Dynamics and Vascular Factors -- 4 Glymphatic System Impairment -- 5 Neuropathological Changes -- 5.1 Metabolic Changes and Neuroinflammation -- 6 Genetic Aspects -- 7 Conclusion -- 8 Key Points -- References -- Genetic Aspects of iNPH -- 1 Introduction -- 2 Familial Studies of iNPH 001484264 5058_ $$a3 Candidate Genes Associated with iNPH -- 3.1 Cilia- and Flagella-Associated Protein 43, CFAP43 -- 3.2 Histone-Associated Genes Products: SFMBT1 -- 3.3 Genes Encoding Cell Membrane-Associated Proteins: CWH43 and AQP -- 3.4 Chromosome 9 Open Reading Frame 72, C9ORF72 -- 3.5 Genes Involved in Amyloid Metabolism -- 3.6 NME8 -- 3.7 Adenosine Receptors A1R and A2AR -- 4 Future Studies: Animal Models and Functional Analysis -- 4.1 Cyclin O, CCNO -- 4.2 Drosophila Studies of SFMBT1 -- 5 Conclusion -- 6 Key Points -- References -- Diagnosis of NPH -- Clinical Symptoms and Examination -- 1 Introduction 001484264 506__ $$aAccess limited to authorized users. 001484264 520__ $$aThis book provides a detailed practically focused guide on the latest diagnostic and treatment techniques available for normal pressure hydrocephalus (NPH). Chapters in this work cover the latest developments related to this condition. It introduces how to use a range of diagnostic modalities including magnetic resonance scanning along with how artificial intelligence and machine learning methodologies can be applied. Cases are presented to reinforce how the methods covered can be appropriately applied and guiding principles are also given to assist the reader in developing a thorough understanding of the topic. Potential complications and means of mitigating these are also described. Normal Pressure Hydrocephalus is a detailed practically applicable resource on NPH with insightful contributions covering relevant aspects of pathophysiology, diagnostic modalities and treatment strategies, making it an ideal resource for all medical practitioners who encounter these patients. 001484264 588__ $$aDescription based on online resource; title from digital title page (viewed on December 12, 2023). 001484264 650_0 $$aHydrocephalus. 001484264 650_6 $$aHydrocéphalie. 001484264 655_0 $$aElectronic books. 001484264 7001_ $$aBradáč, Ondřej. 001484264 77608 $$iPrint version: $$z3031365216$$z9783031365218$$w(OCoLC)1381202614 001484264 852__ $$bebk 001484264 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-36522-5$$zOnline Access$$91397441.1 001484264 909CO $$ooai:library.usi.edu:1484264$$pGLOBAL_SET 001484264 980__ $$aBIB 001484264 980__ $$aEBOOK 001484264 982__ $$aEbook 001484264 983__ $$aOnline 001484264 994__ $$a92$$bISE