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001484282 019__ $$a1410562002
001484282 020__ $$a9783031411922$$qelectronic book
001484282 020__ $$a3031411927$$qelectronic book
001484282 020__ $$z3031411919
001484282 020__ $$z9783031411915
001484282 0247_ $$a10.1007/978-3-031-41192-2$$2doi
001484282 035__ $$aSP(OCoLC)1410592495
001484282 040__ $$aEBLCP$$beng$$erda$$cEBLCP$$dYDX$$dGW5XE$$dYDX$$dOCLCO
001484282 049__ $$aISEA
001484282 050_4 $$aRC692$$b.C56 2023
001484282 08204 $$a616.136$$223/eng/20231207
001484282 24500 $$aCholesterol crystals in atherosclerosis and other related diseases /$$cGeorge S. Abela, Stefan Mark Nidorf, editors.
001484282 264_1 $$aCham, Switzerland :$$bHumana Press,$$c[2023]
001484282 300__ $$a1 online resource (499 p.).
001484282 336__ $$atext$$btxt$$2rdacontent
001484282 337__ $$acomputer$$bc$$2rdamedia
001484282 338__ $$aonline resource$$bcr$$2rdacarrier
001484282 4901_ $$aContemporary cardiology
001484282 500__ $$aIn Vivo Detection of Cholesterol Crystals in Atherosclerotic Plaque with Optical Coherence Tomography
001484282 504__ $$aIncludes bibliographical references and index.
001484282 5050_ $$aIntro -- Preface -- Acknowledgments -- Contents -- Part I: Overview -- Atherosclerosis as a Crystalloid Disease: The Discovery of the Role of Cholesterol Crystals in the Formation and Rupture of Atherosclerotic Plaques -- 1 Historical Views of the Mechanism of Plaque Rupture -- 2 Seeing Cholesterol Crystals in Atherosclerosis in a New Light -- 3 First Insights in the Pro-Inflammatory Potential of Cholesterol Crystals -- 4 Cholesterol Crystals May Contribute to Diseases Other Than Atherosclerosis -- 5 A New Paradigm for the Treatment of Atherosclerosis -- 6 Summary -- References
001484282 5058_ $$aThe Cholesterol Crystal Paradigm: Overview of How Cholesterol Crystals Evolve and Induce Traumatic and Inflammatory Vascular Injury -- 1 Introduction -- 2 Formation of Cholesterol Crystals -- 3 Intra-Cellular Cholesterol Crystals Promote the Formation of Atheroma -- 4 Extra-Cellular Cholesterol Crystals Promote Traumatic and Inflammatory Injury -- 5 Hyperglycemia and Crystal Formation -- 6 Clinical Implications -- References -- Part II: Physical Properties and Imaging of Cholesterol Crystals: In Vitro
001484282 5058_ $$aHow Innovation in Tissue Preparation and Imaging Revolutionized the Understanding of the Role of Cholesterol Crystals in Atherosclerosis -- 1 Background -- 2 Scanning Electron Microscopy Methodology -- 2.1 Tissue Preparation for SEM -- 2.2 Quantification of Cholesterol Crystals -- 2.3 Tissue Shrinkage -- 2.4 Cholesterol Crystal Expansion -- 2.5 Energy Dispersive X-Ray Spectroscopy (EDX) -- 3 Transmission Electron Microscopy with Cryo-Methodology -- 4 Confocal Microscopy Methodology -- 5 Digital Microscopy Methodology -- 6 Phase Contrast and Polarized Light Microscopy -- 7 Infrared Spectroscopy
001484282 5058_ $$a8 Raman Spectroscopy -- 9 Nuclear Magnetic Resonance Spectroscopy -- References -- Crystals in Atherosclerosis: Crystal Cholesterol Structures, Morphologies, Formation and Dissolution. What Do We Know? -- 1 Introduction -- 2 Why Cholesterol? Cholesterol, The Molecule and Its Crystals -- 3 Cholesterol Crystal Morphologies: What Are They, What Do They Mean, and What Do They Show Us? -- 4 Crystal Nucleation -- 4.1 Cholesterol Crystal Formation: The Conceivable Routes, The Hypotheses and the Evidence -- 5 Crystal Dissolution -- 5.1 Lowering Cholesterol Concentration in Blood
001484282 5058_ $$a5.2 Increasing Cholesterol Solubility in Water -- 5.3 Cell Membrane Solubilization of Cholesterol -- 5.4 Crystal Sequestration or Phagocytosis by Macrophages and Esterification or Cellular Efflux of Cholesterol -- 6 Conclusions, Questions, and Suggestions -- 6.1 Cholesterol Crystal Polymorphism: Curiosity or Interesting Possibility? -- 6.2 Cholesterol Crystal Formation: The Locations. Intra-Cellular, Extra-Cellular or Both? -- 6.3 Macrophage Activity: Crystal Formation, Dissolution or Both? -- References -- Part III: Physical Properties and Imaging of Cholesterol Crystals: In Vivo
001484282 506__ $$aAccess limited to authorized users.
001484282 520__ $$aThis book is the first authoritative and comprehensive text dedicated to the understanding of how cholesterol triggers vascular inflammation and mechanical injury that leads to heart attacks, strokes as well as other organ and tissue pathology. It includes chapters on the background of cholesterol crystal formation and methods for their detection as well as a description of the physiochemical transformation of metastable liquid cholesterol to a solid flat plate crystalloid within the cellular and extracellular environment resulting in volume expansion. Chapters also discusses cholesterol crystals and other crystalloid molecules found in atherosclerotic plaque. In addition, the book examines how cholesterol crystals can induce similar injurious processes in other organs including the retina of the eye to cause blindness, in solid cancers causing further tumor growth and in the brain of patients with Alzheimers. And lastly, the book addresses various potential therapeutics that disrupt the physiochemical transformation of cholesterol from a liquid to a solid, inhibit its role in triggering inflammation and tissue injury while ushering a path towards targeted therapies. Cholesterol Crystals in Atherosclerosis and Other Related Diseases will be of interest to cardiologists as well as individuals in various fields of science including crystallography, basic and clinical imaging, cardiac oncology, and drug discovery.
001484282 588__ $$aDescription based on online resource; title from digital title page (viewed on December 07, 2023).
001484282 650_6 $$aAthérosclérose.
001484282 650_6 $$aCholestérolémie.
001484282 650_6 $$aCœur$$xMaladies$$xÉtiologie.
001484282 650_0 $$aAtherosclerosis.$$0(DLC)sh 85009129
001484282 650_0 $$aBlood cholesterol.
001484282 650_0 $$aHeart$$xDiseases$$xEtiology.$$0(DLC)sh 85007430
001484282 655_0 $$aElectronic books.
001484282 7001_ $$aAbela, George S.
001484282 7001_ $$aNidorf, Stefan Mark.
001484282 77608 $$iPrint version:$$aAbela, George S.$$tCholesterol Crystals in Atherosclerosis and Other Related Diseases$$dCham : Springer International Publishing AG,c2023
001484282 830_0 $$aContemporary cardiology (Totowa, N.J.)
001484282 852__ $$bebk
001484282 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-41192-2$$zOnline Access$$91397441.1
001484282 909CO $$ooai:library.usi.edu:1484282$$pGLOBAL_SET
001484282 980__ $$aBIB
001484282 980__ $$aEBOOK
001484282 982__ $$aEbook
001484282 983__ $$aOnline
001484282 994__ $$a92$$bISE