@article{1484342,
      recid = {1484342},
      author = {Dugbartey, George J. and Sener, Alp,},
      title = {Hydrogen sulfide in kidney diseases : a novel  pharmacotherapy /},
      pages = {1 online resource (xv, 229 pages) :},
      note = {Includes index.},
      abstract = {This book is the first to present the therapeutic benefits  of hydrogen sulfide in various kidney diseases. Hydrogen  sulfide (H2S), a gas with a distinctive smell of rotten  eggs, was known for over three centuries for its toxicity  and death at high concentrations especially among  agricultural and industrial workers. This is due to its  ability to reversibly antagonize complex IV of the  mitochondrial electron transport chain. However, studies  over the past two decades have shown that H2S has risen  above its historic notorious label and has received  significant experimental attention as an endogenously  produced gaseous signaling molecule that plays an important  role in cellular homeostasis and influences a myriad of  physiological and pathological processes at low  concentrations. Its production is enzymatically regulated  and has specific molecular targets. Several recent in vitro  and in vivo studies have demonstrated that at low  micromolar concentrations, H2S exhibits important  therapeutic characteristics that target multiple molecular  pathways and thereby preventing the development and  progression of several pathologies. This beneficial effect  of H2S suggests that it may meet the demand for alternative  and/or additional therapeutic agents against various renal  pathologies in which reduced levels of renal and plasma H2S  were observed. Interestingly, while the distribution of  H2S-producing enzymes is tissue-specific, they are  abundantly expressed in the glomeruli and in the brush  border and cytoplasm of epithelial cells of the renal  tubules and in the peritubular capillaries. This makes the  kidney a rich source of endogenous H2S production. From  pre-clinical and clinical perspectives, this book is  topical and timely, and seeks to lay the foundation for  future clinical applications of H2S in nephrology. Hydrogen  Sulfide in Kidney Diseases: A Novel Pharmacotherapy serves  as a good resource for educational and didactic purposes  towards novel treatment of kidney diseases and other  aspects of clinical medicine. It is an excellent guide for  nephrologists, pharmacologists, and residents in  nephrology.},
      url = {http://library.usi.edu/record/1484342},
      doi = {https://doi.org/10.1007/978-3-031-44041-0},
}