001484342 000__ 05039cam\\2200553\i\4500
001484342 001__ 1484342
001484342 003__ OCoLC
001484342 005__ 20240117003321.0
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001484342 007__ cr\un\nnnunnun
001484342 008__ 231127s2023\\\\sz\a\\\\o\\\\\001\0\eng\d
001484342 019__ $$a1409639351$$a1409702610
001484342 020__ $$a9783031440410$$q(electronic bk.)
001484342 020__ $$a3031440412$$q(electronic bk.)
001484342 020__ $$z9783031440403
001484342 020__ $$z3031440404
001484342 0247_ $$a10.1007/978-3-031-44041-0$$2doi
001484342 035__ $$aSP(OCoLC)1410735862
001484342 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dOCLCO$$dYDX$$dEBLCP
001484342 049__ $$aISEA
001484342 050_4 $$aRC903
001484342 08204 $$a616.6/106$$223/eng/20231127
001484342 1001_ $$aDugbartey, George J.$$eauthor.
001484342 24510 $$aHydrogen sulfide in kidney diseases :$$ba novel pharmacotherapy /$$cGeorge J. Dugbartey, Alp Sener.
001484342 264_1 $$aCham :$$bSpringer,$$c2023.
001484342 300__ $$a1 online resource (xv, 229 pages) :$$billustrations (some color)
001484342 336__ $$atext$$btxt$$2rdacontent
001484342 337__ $$acomputer$$bc$$2rdamedia
001484342 338__ $$aonline resource$$bcr$$2rdacarrier
001484342 500__ $$aIncludes index.
001484342 5050_ $$aChapter 1: Hydrogen Sulfide and the Renal System -- Chapter 2: Hydrogen Sulfide for Cisplatin-Induced Acute Kidney Injury -- Chapter 3: Hydrogen Sulfide as a Therapeutic Alternative for Chronic Kidney Disease -- Chapter 4: Hydrogen Sulfide in Diabetic Kidney Disease -- Chapter 5: Hydrogen Sulfide for the Treatment of Hypertensive Nephropathy -- Chapter 6: Hydrogen Sulfide as a Potential Therapy for COVID-19-Associated Nephropathy -- Chapter 7: Hydrogen Sulfide as a Potential Novel Therapy to Prevent Renal Damage During Ureteral Obstruction -- Chapter 8: Hydrogen Sulfide Therapy as the Future of Renal Graft Preservation -- Chapter 9: Hydrogen Sulfide against Ischemia-Reperfusion Injury in Transplantation of Kidney and Other Transplantable Solid Organs -- Chapter 10: FDA-Approved Hydrogen Sulfide Donor Drug and its Clinical Applications in Nephrology.
001484342 506__ $$aAccess limited to authorized users.
001484342 520__ $$aThis book is the first to present the therapeutic benefits of hydrogen sulfide in various kidney diseases. Hydrogen sulfide (H2S), a gas with a distinctive smell of rotten eggs, was known for over three centuries for its toxicity and death at high concentrations especially among agricultural and industrial workers. This is due to its ability to reversibly antagonize complex IV of the mitochondrial electron transport chain. However, studies over the past two decades have shown that H2S has risen above its historic notorious label and has received significant experimental attention as an endogenously produced gaseous signaling molecule that plays an important role in cellular homeostasis and influences a myriad of physiological and pathological processes at low concentrations. Its production is enzymatically regulated and has specific molecular targets. Several recent in vitro and in vivo studies have demonstrated that at low micromolar concentrations, H2S exhibits important therapeutic characteristics that target multiple molecular pathways and thereby preventing the development and progression of several pathologies. This beneficial effect of H2S suggests that it may meet the demand for alternative and/or additional therapeutic agents against various renal pathologies in which reduced levels of renal and plasma H2S were observed. Interestingly, while the distribution of H2S-producing enzymes is tissue-specific, they are abundantly expressed in the glomeruli and in the brush border and cytoplasm of epithelial cells of the renal tubules and in the peritubular capillaries. This makes the kidney a rich source of endogenous H2S production. From pre-clinical and clinical perspectives, this book is topical and timely, and seeks to lay the foundation for future clinical applications of H2S in nephrology. Hydrogen Sulfide in Kidney Diseases: A Novel Pharmacotherapy serves as a good resource for educational and didactic purposes towards novel treatment of kidney diseases and other aspects of clinical medicine. It is an excellent guide for nephrologists, pharmacologists, and residents in nephrology.
001484342 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed November 27, 2023).
001484342 650_6 $$aReins$$xMaladies$$xChimiothérapie.
001484342 650_6 $$aSulfure d'hydrogène$$xEmploi en thérapeutique.
001484342 650_0 $$aKidneys$$xDiseases$$xChemotherapy.
001484342 650_0 $$aHydrogen sulfide$$xTherapeutic use.$$0(DLC)sh 85063433
001484342 655_0 $$aElectronic books.
001484342 7001_ $$aSener, Alp,$$eauthor.
001484342 77608 $$iPrint version: $$z3031440404$$z9783031440403$$w(OCoLC)1393300472
001484342 852__ $$bebk
001484342 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-44041-0$$zOnline Access$$91397441.1
001484342 909CO $$ooai:library.usi.edu:1484342$$pGLOBAL_SET
001484342 980__ $$aBIB
001484342 980__ $$aEBOOK
001484342 982__ $$aEbook
001484342 983__ $$aOnline
001484342 994__ $$a92$$bISE