Targeting the DNA damage response for cancer therapy / Timothy A. Yap, Geoffrey I. Shapiro, editors.
Yap, Timothy A., editor.; Shapiro, Geoffrey I. editor.
2023
RC270.8
Available Online

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Title Targeting the DNA damage response for cancer therapy / Timothy A. Yap, Geoffrey I. Shapiro, editors.
ISBN 9783031300653 (electronic bk.)
3031300653 (electronic bk.)
3031300645
9783031300646
DOI https://doi.org/10.1007/978-3-031-30065-3
Published Cham : Springer, 2023.
Language English
Description 1 online resource (420 pages) : illustrations (black and white, and color).
Item Number 10.1007/978-3-031-30065-3 doi
Call Number RC270.8
Dewey Decimal Classification 616.99406
Summary This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic. Targeting the DNA Damage Response for Cancer Therapy comprehensively reviews the application of PARP and other DDR inhibitors across oncology disciplines. Therefore, it is a valuable resource for all medical professionals and researchers who use or who are researching the use of these inhibitors on a day-to-day basis.
Access Note Access limited to authorized users.
Source of Description Description based on print version record.
Added Author Yap, Timothy A., editor.
Shapiro, Geoffrey I. editor.
Series Cancer treatment and research ; v. 186.
Available in Other Form TARGETING THE DNA DAMAGE RESPONSE FOR CANCER THERAPY.
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Record Appears in Online Resources > Ebooks
All Resources
Evolution of the development of PARP inhibitors
Exploiting cancer synthetic lethality in cancer Lessons learnt from PARP inhibitors
Mechanisms of PARP inhibitor resistance
Development of homologous recombination functional assays for targeting the DDR
Clinical application of Poly(ADP Ribose) Polymerase (PARP) inhibitors in ovarian cancer
Clinical use of PARP inhibitors in BRCA mutant and non-BRCA mutant breast cancer
Development of PARP inhibitors in targeting castration-resistant prostate cancer
Strategies for the management of patients with pancreatic cancer with PARP inhibitors
Combining poly (ADP-ribose) polymerase (PARP) inhibitors with chemotherapeutic agents: Promise and challenges
Rational combinations of PARP inhibitors with HRD-inducing molecularly targeted agents
Combining PARP inhibition and immunotherapy in BRCA-associated cancers
Mitotic MTH1 inhibitors in treatment of cancer
Targeting ATR in cancer medicine
Targeting polymerase Theta (POLq) for cancer therapy
Targeting DNA-PK
WRN is a promising synthetic lethal target for cancers with microsatellite instability (MSI).

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