Targeting the DNA damage response for cancer therapy / Timothy A. Yap, Geoffrey I. Shapiro, editors.
Yap, Timothy A., editor.; Shapiro, Geoffrey I. editor.
2023
RC270.8
Available Online

Linked e-resources

Linked Resource
Online Access
Concurrent users
Unlimited
Authorized users
Authorized users
Document Delivery Supplied
Can lend chapters, not whole ebooks

Details

Title
Targeting the DNA damage response for cancer therapy / Timothy A. Yap, Geoffrey I. Shapiro, editors.
ISBN
9783031300653 (electronic bk.)
3031300653 (electronic bk.)
3031300645
9783031300646
DOI
https://doi.org/10.1007/978-3-031-30065-3
Published
Cham : Springer, 2023.
Language
English
Description
1 online resource (420 pages) : illustrations (black and white, and color).
Item Number
10.1007/978-3-031-30065-3 doi
Call Number
RC270.8
Dewey Decimal Classification
616.99406
Summary
This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic. Targeting the DNA Damage Response for Cancer Therapy comprehensively reviews the application of PARP and other DDR inhibitors across oncology disciplines. Therefore, it is a valuable resource for all medical professionals and researchers who use or who are researching the use of these inhibitors on a day-to-day basis.
Access Note
Access limited to authorized users.
Source of Description
Description based on print version record.
Added Author
Yap, Timothy A., editor.
Shapiro, Geoffrey I. editor.
Series
Cancer treatment and research ; v. 186.
Available in Other Form
TARGETING THE DNA DAMAGE RESPONSE FOR CANCER THERAPY.
Linked Resources
Online Access
Record Appears in
Online Resources > Ebooks
All Resources
Evolution of the development of PARP inhibitors
Exploiting cancer synthetic lethality in cancer Lessons learnt from PARP inhibitors
Mechanisms of PARP inhibitor resistance
Development of homologous recombination functional assays for targeting the DDR
Clinical application of Poly(ADP Ribose) Polymerase (PARP) inhibitors in ovarian cancer
Clinical use of PARP inhibitors in BRCA mutant and non-BRCA mutant breast cancer
Development of PARP inhibitors in targeting castration-resistant prostate cancer
Strategies for the management of patients with pancreatic cancer with PARP inhibitors
Combining poly (ADP-ribose) polymerase (PARP) inhibitors with chemotherapeutic agents: Promise and challenges
Rational combinations of PARP inhibitors with HRD-inducing molecularly targeted agents
Combining PARP inhibition and immunotherapy in BRCA-associated cancers
Mitotic MTH1 inhibitors in treatment of cancer
Targeting ATR in cancer medicine
Targeting polymerase Theta (POLq) for cancer therapy
Targeting DNA-PK
WRN is a promising synthetic lethal target for cancers with microsatellite instability (MSI).

Browse Subjects

Show more subjects...

Statistics

from
to
Export