Intro
Contents
Part I: Brain Tumor Primer
1: Malignant Glioma
Clinical Scenario
Making the Diagnosis
Post-operative Treatment
Radiation
Chemotherapy
Tumor Treating Fields
Symptom Management
Surveillance
Treatment at Recurrence
Prognosis/Survivorship
Trends and Future Directions
References
2: Diffuse Astrocytoma
Clinical Vignette
Clinical Features
Surgical Decision-Making
Pathology
Risk Stratification and Selection of Patients for Treatment
Post-operative Treatment
Chemotherapy Dosing and Symptom Management
TMZ
PCV

Fertility Preservation (FP)
Surveillance
Treatment at Recurrence
Prognosis and Survivorship
Patient Information
References
3: Oligodendroglioma
The Clinical Scenario
Making the Diagnosis
The Role of Surgery
Integrated Histopathologic-Molecular Diagnosis
Post-operative Treatment
Radiation
Chemotherapy
Surveillance
Treatment at Recurrence (Regimens with Dosing)
Prognosis
Trends and Future Directions
Patient Information
References
4: BRAF-Mutated Glioma
The Clinical Scenario
Making the Diagnosis
BRAF Mutations

BRAF-Mutation Frequency by Tumor Type
Post-operative Treatment
Low Grade Glioma
High-Grade Glioma
Targeted Therapy Regimens and Dosing
Surveillance While on Treatment
Management of Common Toxicities
Treatment at Recurrence
Prognosis/Survivorship
Trends and Future Directions: When Do you Consider a Clinical Trial?
References
5: Treatment of Meningioma
Introduction
Clinical Scenario
Diagnostic Evaluation
Imaging
Pathology
Therapeutic Management
Surgery
Radiation
Systemic Therapies
Conclusions
References

6: Treatment of Primary CNS Lymphoma
Introduction
Clinical Scenario
Epidemiology
Diagnosis and Staging
Diagnosis
Staging
First-Line Treatment
Methotrexate Therapy
Supportive Medication and Monitoring
Concomitant Medications
Methotrexate Toxicity
Common Induction Regimens
R-MVP
MT-R
MATRix
R-MBVP
Role of Rituximab
Site-Specific Therapy
Common Consolidation Regimens
Relapsed Disease
Expectations from Treatment
Patient Information
What Type of Tumor Do I Have?
How Do I Treat It?

What Can I Expect to Experience During Treatment?
How Will We Keep an Eye on This?
What Is My Prognosis?
References
7: Adult Medulloblastoma
The Clinical Scenario
Clinical Presentation
Genetic Testing
Radiographic Finding
Staging
Pathologic and Molecular Findings
First Line Treatment
Clinical Risk Stratification
Surgery
Craniospinal Irradiation
Systemic Therapy
Surveillance
Prognosis
Recurrent Disease Treatment
Survivorship
Future Directions
References
8: Treatment of Ependymoma
The Clinical Scenario
Making the Diagnosis