Intro
Foreword
Preface
Contents
Contributors
I: The Best Clinical Cases in Severe Infections and Sepsis
1: Principles and Management of Sepsis
1.1 Introduction
1.1.1 Prevalence
1.1.2 Relevance and Importance
1.2 Definition
1.2.1 Evolution and History of Sepsis Definition
1.3 Components of Sepsis Therapy
1.3.1 Sepsis Identification and Diagnostics
1.3.2 Basics of Sepsis Therapy: "Golden Hour of Sepsis"
1.3.3 Treatment of Septic Shock
1.3.4 Additional Treatment Options: New Recommendations

1.4 Future Development and Precision Therapy Options-New Diagnostics
1.4.1 New Ways of Characterizing Sepsis: From Transcriptome to Precise Medical Therapy
1.4.2 New eHealth Strategies
1.4.3 New Diagnostic Approaches
1.4.3.1 Next-Generation Sequencing (NGS)
1.4.3.2 The Transcriptome of White Blood Cells
1.5 Follow-up Programs for Post-Sepsis Patients
References
2: Infection in an Immunocompromised Patient, the Perfect Costume in Which to Hide
2.1 Introduction
Case Presentation
2.2 Investigations
2.3 Differential Diagnosis
2.4 Treatment

2.4.1 Nonpharmacological Treatment
2.4.2 Pharmacological Treatment
2.5 Evolution, Outcome, and Follow-up
2.6 Discussion
Summary
References
3: Intraabdominal Sepsis: Portal and Mesenteric Vein Thrombosis as First Presentation of Myeloproliferative Disease in a Young Woman
3.1 Introduction
3.2 Investigations
3.3 Differential Diagnosis
3.4 Treatment
3.5 Evolution, Outcome, and Follow-up
3.6 Discussion
References
4: Necrotizing Fasciitis
4.1 Introduction
4.2 Investigations
4.3 Differential Diagnosis
4.4 Treatment

4.5 Evolution, Outcome, and Follow-up
4.6 Discussion
5: Fournier's Gangrene Secondary to Perforated Retrocaecal Appendicitis: A Turbulent and Prolonged ICU Admission
5.1 Introduction
Case Presentation
5.2 Investigations
5.3 Differential Diagnosis
5.4 Treatment
5.5 Evolution, Outcome, and Follow-up
5.6 Discussion
Summary
References
6: The Use of Venous-Venous Extracorporeal Membrane Oxygenation in a Patient with Severe Acute Respiratory Distress Syndrome and Multiple Organ Failure Due to Septic Shock: A Case Report
6.1 Introduction
Case Presentation

6.2 Investigations
6.2.1 Blood Exams
6.2.2 Instrumental Exams
6.2.3 Hemodynamic Monitoring
6.2.4 Microbiology
6.3 Treatment
6.3.1 Emergency Department
6.3.2 Intensive Care Unit-Peripheral Hospital
6.3.3 Intensive Care Unit-Hub Hospital
6.3.3.1 Respiratory Treatment
6.3.3.2 Hemodynamic
6.3.3.3 Infectious Disease
6.3.3.4 Renal Replacement Therapy
6.3.3.5 Hematology
6.3.3.6 Surgery
6.3.3.7 Nutrition
6.4 Evolution, Outcome and Follow-up
6.5 Discussion
Summary
References
7: Viral Infections in the Intensive Care Unit
7.1 Introduction