Human iPSC-derived disease models for drug discovery / Markus H. Kuehn, Wei Zhu, editors.
Kuehn, Markus H. editor.; Zhu, Wei, editor. 1940-
2023
QH588.S83
Available Online

Linked e-resources

Linked Resource Online Access
Concurrent users Unlimited
Authorized users Authorized users
Document Delivery Supplied Can lend chapters, not whole ebooks

Details

Title Human iPSC-derived disease models for drug discovery / Markus H. Kuehn, Wei Zhu, editors.
ISBN 9783031423499 (electronic bk.)
3031423496 (electronic bk.)
9783031423482
3031423488
DOI https://doi.org/10.1007/978-3-031-42349-9
Published Cham : Springer, 2023.
Language English
Description 1 online resource (viii, 332 pages) : illustrations (some color).
Other Standard Identifiers 10.1007/978-3-031-42349-9 doi
Call Number QH588.S83
Dewey Decimal Classification 616.02/774
Summary Since their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to regenerative medicine technologies, and provided exceptional opportunities for pharmacologic research. These cells provide an essentially unlimited supply of cell types that are difficult to obtain from patients, such as neurons or cardiomyocytes, or are difficult to maintain in primary cell culture. iPSC can be obtained from patients afflicted with a particular disease but, in combination with recently developed gene editing techniques, can also be modified to generate disease models. Moreover, the new techniques of 3 Dimensional printing and materials science facilitate the generation of organoids that can mirror organs under disease conditions. These properties make iPSC powerful tools to study how diseases develop and how they may be treated. In addition, iPSC can also be used to treat conditions in which the target cell population has been lost and such regenerative approaches hold great promise for currently untreatable diseases, including cardiac failure or photoreceptor degenerations.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed November 30, 2023).
Added Author Kuehn, Markus H. editor.
Zhu, Wei, editor. 1940-
Series Handbook of experimental pharmacology ; v. 281. 1865-0325
Available in Other Form Print version: 9783031423482
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
All Resources
Part 1 General considerations
Human iPS for clinical applications and cellular products
3D-printed iPS disease models
Part 2 CNS iPSC and organoids
iPS-derived neurons and brain organoids from patients (brain)
iPS-derived RGCs (eye)
iPS-derived glia (brain)
iPSC to model blood-brain barrier endothelial cells
Part 3 iPSC-derived nociceptive neurons
IPSC-based peripheral nerve modeling
Part 4 Non-neuronal specialized cell types
iPSC-based drug screening of differentiated cardiomyocyte subtypes
iPSC-based cardiac disease modeling: from cell to tissue
iPSC-derived corneal endothelial cell
iPSC-derived trabecular meshwork (eye)
iPSC for in vitro disease modeling of diabetes.

Browse Subjects

Show more subjects...

Statistics

from
to
Export