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001484429 001__ 1484429
001484429 003__ OCoLC
001484429 005__ 20240117003324.0
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001484429 008__ 231130s2023\\\\sz\a\\\\o\\\\\000\0\eng\d
001484429 019__ $$a1410863976$$a1410928732$$a1411017769
001484429 020__ $$a9783031423499$$q(electronic bk.)
001484429 020__ $$a3031423496$$q(electronic bk.)
001484429 020__ $$z9783031423482
001484429 020__ $$z3031423488
001484429 0247_ $$a10.1007/978-3-031-42349-9$$2doi
001484429 035__ $$aSP(OCoLC)1411035892
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001484429 049__ $$aISEA
001484429 050_4 $$aQH588.S83
001484429 08204 $$a616.02/774$$223/eng/20231130
001484429 24500 $$aHuman iPSC-derived disease models for drug discovery /$$cMarkus H. Kuehn, Wei Zhu, editors.
001484429 264_1 $$aCham :$$bSpringer,$$c2023.
001484429 300__ $$a1 online resource (viii, 332 pages) :$$billustrations (some color).
001484429 336__ $$atext$$btxt$$2rdacontent
001484429 337__ $$acomputer$$bc$$2rdamedia
001484429 338__ $$aonline resource$$bcr$$2rdacarrier
001484429 4901_ $$aHandbook of experimental pharmacology,$$x1865-0325 ;$$vvolume 281
001484429 5050_ $$aPart 1 General considerations -- Human iPS for clinical applications and cellular products -- 3D-printed iPS disease models -- Part 2 CNS iPSC and organoids -- iPS-derived neurons and brain organoids from patients (brain) -- iPS-derived RGCs (eye) -- iPS-derived glia (brain) -- iPSC to model blood-brain barrier endothelial cells -- Part 3 iPSC-derived nociceptive neurons -- IPSC-based peripheral nerve modeling -- Part 4 Non-neuronal specialized cell types -- iPSC-based drug screening of differentiated cardiomyocyte subtypes -- iPSC-based cardiac disease modeling: from cell to tissue -- iPSC-derived corneal endothelial cell -- iPSC-derived trabecular meshwork (eye) -- iPSC for in vitro disease modeling of diabetes.
001484429 506__ $$aAccess limited to authorized users.
001484429 520__ $$aSince their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to regenerative medicine technologies, and provided exceptional opportunities for pharmacologic research. These cells provide an essentially unlimited supply of cell types that are difficult to obtain from patients, such as neurons or cardiomyocytes, or are difficult to maintain in primary cell culture. iPSC can be obtained from patients afflicted with a particular disease but, in combination with recently developed gene editing techniques, can also be modified to generate disease models. Moreover, the new techniques of 3 Dimensional printing and materials science facilitate the generation of organoids that can mirror organs under disease conditions. These properties make iPSC powerful tools to study how diseases develop and how they may be treated. In addition, iPSC can also be used to treat conditions in which the target cell population has been lost and such regenerative approaches hold great promise for currently untreatable diseases, including cardiac failure or photoreceptor degenerations.
001484429 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed November 30, 2023).
001484429 650_6 $$aMédicaments$$xRecherche.
001484429 650_0 $$aInduced pluripotent stem cells$$xSimulation methods.
001484429 650_0 $$aDrugs$$xResearch.$$0(DLC)sh 89007049
001484429 655_0 $$aElectronic books.
001484429 7001_ $$aKuehn, Markus H.$$eeditor.
001484429 7001_ $$aZhu, Wei,$$eeditor.$$d1940-$$0(OCoLC)oca00056345
001484429 77608 $$iPrint version: $$z3031423488$$z9783031423482$$w(OCoLC)1390680777
001484429 830_0 $$aHandbook of experimental pharmacology ;$$vv. 281.$$x1865-0325
001484429 852__ $$bebk
001484429 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-42349-9$$zOnline Access$$91397441.1
001484429 909CO $$ooai:library.usi.edu:1484429$$pGLOBAL_SET
001484429 980__ $$aBIB
001484429 980__ $$aEBOOK
001484429 982__ $$aEbook
001484429 983__ $$aOnline
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