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Table of Contents
Intro
Preface
Acknowledgment
Contents
Editors and Contributors
1: Development and Synthesis of Block Co-polymer and their Role in Nanotechnology
1.1 Introduction
1.1.1 Nomenclature
1.1.2 Physical Properties
1.1.3 Thermal Properties
1.1.4 Processability
1.1.5 Mechanical Properties
1.1.6 Optical Properties
1.1.7 Chemical Resistance
1.1.8 Transport Properties
1.1.9 Blending Properties
1.2 Classification of Block Copolymers
1.2.1 Based on Chain Length
1.2.1.1 Linear Block Copolymer
1.2.1.2 Nonlinear Block Copolymers
1.2.1.3 Star-Block Copolymers
1.2.1.4 Miktoarm Star Copolymers
1.2.2 Based on Properties
1.2.2.1 Hydrophilic Block Copolymer
1.2.2.2 Hydrophobic Block Copolymers
1.2.2.3 Amphiphilic Block Copolymers
1.3 Synthesis of Block Copolymers with Distinct Structures Can Be Accomplished Using One of Three Main Methods
1.3.1 Living Polymerization by Sequential Additions of Different Monomers
1.3.2 Living Polymerization of the Original Polymer Chain Via the Addition of a Terminal End
1.3.3 Via the Addition of Highly Reactive Functional Groups between Different Polymers in the Final Reaction Step
1.3.4 Living Polymerization by Sequential Additions of Different Monomers
1.3.4.1 Living Anionic Polymerization
1.3.4.2 Living Cationic Polymerization
1.3.4.3 Controlled/Living Radical Polymerization
1.3.4.4 Other Living Polymerizations Methods
1.4 Different Polymeric Formulations and their Pharmaceutical Applications
1.4.1 Micelles
1.4.2 Hydrogels
1.4.3 Polymersomes
1.4.4 Cubosomes
1.4.5 Other Nanostructure System
1.5 Conclusion
References
2: Role of Block Co-Polymers in Drug Delivery
2.1 Introduction
2.2 Polymeric Nanocarriers for Drug Delivery
2.2.1 Nanoparticles
2.2.2 Micelles
2.2.3 Hydrogel
2.3 Stimuli-Responsive Polymers for Drug Delivery
2.3.1 Temperature-Sensitive Drug Delivery Systems
2.3.2 Redox-Responsive Polymeric Drug Delivery Systems
2.3.3 Light-Responsive Polymeric Drug Delivery Systems
2.3.4 Enzyme-Sensitive Polymers
2.4 Conclusion and Future Prospects
References
3: Role of Block Copolymers in the Enhancement of Poor Solubility of Drugs
3.1 Introduction
3.2 Solubility Enhancement by Micelle Formation Using Block-Copolymer
3.3 Mechanism of Solubilization by Micelles
3.4 Latest Studies on Solubility Enhancement by Micelles Using Block Copolymers
3.5 Solubility Enhancement by Solid Dispersion Using Block Copolymer
3.6 Technique for Making Solid Dispersions (SDD)
3.7 Latest Studies on Solubility Enhancement by SDD Using Block Copolymers
3.8 Conclusion
References
4: Synthesis and Self-Assembly of Block Copolymers
4.1 Introduction
4.2 Methodologies for Synthesis of Block Copolymers
Preface
Acknowledgment
Contents
Editors and Contributors
1: Development and Synthesis of Block Co-polymer and their Role in Nanotechnology
1.1 Introduction
1.1.1 Nomenclature
1.1.2 Physical Properties
1.1.3 Thermal Properties
1.1.4 Processability
1.1.5 Mechanical Properties
1.1.6 Optical Properties
1.1.7 Chemical Resistance
1.1.8 Transport Properties
1.1.9 Blending Properties
1.2 Classification of Block Copolymers
1.2.1 Based on Chain Length
1.2.1.1 Linear Block Copolymer
1.2.1.2 Nonlinear Block Copolymers
1.2.1.3 Star-Block Copolymers
1.2.1.4 Miktoarm Star Copolymers
1.2.2 Based on Properties
1.2.2.1 Hydrophilic Block Copolymer
1.2.2.2 Hydrophobic Block Copolymers
1.2.2.3 Amphiphilic Block Copolymers
1.3 Synthesis of Block Copolymers with Distinct Structures Can Be Accomplished Using One of Three Main Methods
1.3.1 Living Polymerization by Sequential Additions of Different Monomers
1.3.2 Living Polymerization of the Original Polymer Chain Via the Addition of a Terminal End
1.3.3 Via the Addition of Highly Reactive Functional Groups between Different Polymers in the Final Reaction Step
1.3.4 Living Polymerization by Sequential Additions of Different Monomers
1.3.4.1 Living Anionic Polymerization
1.3.4.2 Living Cationic Polymerization
1.3.4.3 Controlled/Living Radical Polymerization
1.3.4.4 Other Living Polymerizations Methods
1.4 Different Polymeric Formulations and their Pharmaceutical Applications
1.4.1 Micelles
1.4.2 Hydrogels
1.4.3 Polymersomes
1.4.4 Cubosomes
1.4.5 Other Nanostructure System
1.5 Conclusion
References
2: Role of Block Co-Polymers in Drug Delivery
2.1 Introduction
2.2 Polymeric Nanocarriers for Drug Delivery
2.2.1 Nanoparticles
2.2.2 Micelles
2.2.3 Hydrogel
2.3 Stimuli-Responsive Polymers for Drug Delivery
2.3.1 Temperature-Sensitive Drug Delivery Systems
2.3.2 Redox-Responsive Polymeric Drug Delivery Systems
2.3.3 Light-Responsive Polymeric Drug Delivery Systems
2.3.4 Enzyme-Sensitive Polymers
2.4 Conclusion and Future Prospects
References
3: Role of Block Copolymers in the Enhancement of Poor Solubility of Drugs
3.1 Introduction
3.2 Solubility Enhancement by Micelle Formation Using Block-Copolymer
3.3 Mechanism of Solubilization by Micelles
3.4 Latest Studies on Solubility Enhancement by Micelles Using Block Copolymers
3.5 Solubility Enhancement by Solid Dispersion Using Block Copolymer
3.6 Technique for Making Solid Dispersions (SDD)
3.7 Latest Studies on Solubility Enhancement by SDD Using Block Copolymers
3.8 Conclusion
References
4: Synthesis and Self-Assembly of Block Copolymers
4.1 Introduction
4.2 Methodologies for Synthesis of Block Copolymers