Intro
Preface
Acknowledgments
Contents
1: Introduction to Infectious Diseases
1.1 Current Impact of Human Infectious Diseases: The Good News
1.2 Emergence and Reemergence of Human Infectious Diseases: The Bad News
1.3 Infectious Diseases in Animals
1.4 Infectious Diseases in Plants
1.5 Biology and the Need for Better Understanding of Infectious Diseases
1.6 Chapter Summary
Further Reading
2: The Germ Theory Paradigm
2.1 Perceptions of Infectious Diseases Before the Germ Theory
2.2 Early Contributions to Germ Theory

2.3 Louis Pasteur's Contributions to the Germ Theory
2.4 Robert Koch's Contributions to the Germ Theory
2.5 Major Advancements Since the Acceptance of Germ Theory
2.6 Contributions of Germ Theory to Combating Disease
2.6.1 Water, Sanitation, and Hygiene
2.6.2 Vector Control
2.6.3 Vaccination
2.6.4 Antibiotics
2.7 Chapter Summary
Further Reading
3: Host-Microbe Interactions and Infectious Disease
3.1 Microbes as Pathogens
3.2 Basic Concepts in Host-Microbe Interactions
3.3 Temporal Progression of a Host-Microbe Interaction

3.4 The Diversity of Host-Microbe Interactions: Mutualism, Commensalism, and Parasitism
3.5 What Is a Pathogen? Pathogenicity and Virulence
3.6 Damage-Response Framework
3.7 An Interaction-Centric Perspective on Disease
3.8 The Environmental Context of Host-Microbe Interactions
3.9 Chapter Summary
Further Reading
4: Viruses
4.1 Viral Morphology
4.2 Viral Genomes
4.3 Evolutionary Origin of Viruses
4.4 Classification of Viruses by Production of Messenger RNA (mRNA)
4.5 Viral Gene Expression and Pathogenesis

4.6 Mutation and Recombination/Reassortment in Viruses
4.7 Viral Infection Cycles
4.8 Positive-Sense ssRNA Viruses: Poliovirus
4.9 dsDNA Viruses: Adenovirus
4.10 Negative-Sense ssRNA Viruses: Influenza A Virus
4.11 Retroviruses: HIV
4.12 Viruses of Bacteria and Archaea
4.13 Plant Viruses: Tobacco Mosaic Virus
4.14 Prions
4.15 Chapter Summary
Further Reading
5: Bacteria
5.1 Bacterial Morphology
5.2 Biofilms
5.3 Bacterial Genomes
5.4 Horizontal Gene Transfer
5.5 Bacterial Pathogenesis and Virulence Factors
5.6 E. coli

5.7 Vibrio cholerae
5.8 Staphylococcus aureus
5.9 Mycobacterium tuberculosis
5.10 Bacterial Plant Pathogens
5.11 Chapter Summary
Further Reading
6: Protozoa
6.1 Protozoan Morphology
6.2 Protozoan Reproduction
6.2.1 Asexual Reproduction
6.2.2 Sexual Reproduction
6.3 Protozoan Genomics
6.4 Protozoan Life Cycles
6.5 Entamoeba histolytica
6.6 Plasmodium falciparum
6.7 Toxoplasma gondii
6.8 Trypanosomes
6.8.1 Trypanosoma brucei
6.8.2 Trypanosoma cruzi
6.9 Leishmania Species
6.10 Protozoan Parasites of Animals