Background. Inhibitory control deficits may be one important cause for smartphone addiction. The available studies have shown that acute aerobic exercise may improve the inhibitory control. However, there is still lack of research on how regimens of an acute exercise affect this inhibitory control. 'e present study was to examine the effects of an acute aerobic exercise at three different exercise intensities on changes in the inhibitory control function including response inhibition and interference control in college students with smartphone addiction. Methods. Participants (n = 30; age 20.03 ± 0.96 years) with smartphone addiction were identified by the Mobile Phone Addiction Tendency Scale for College Students and randomized to study 1 and study 2 with 15 individuals each. Fifteen participants in study 1 were tested by the Go/NoGo task to explore the response inhibition, while other fifteen in study 2 were tested by the Flanker task to examine the interference control. 'e participants in study 1 and 2 were randomly assigned to three groups (5 in each) with exercising at low, moderate, and high intensity. 'e individual response inhibition and interference control were measured before and after 30 minutes acute aerobic exercise, respectively. Results. In study 1, the accuracy of NoGo stimulus after 30 minutes of acute aerobic exercise was significantly increased (p ≤ 0.001) while the response time (RT) of Go stimulus was significantly decreased (p ≤ 0.001). 'e largest changes occurred in the moderate-intensity group for the accuracy of NoGo stimulus (p = 0.012) and for the RT of Go stimulus (p ≤ 0.001). 'e results in study 2 showed no significant change in all three groups after exercise. Conclusions. 30 minutes of acute aerobic exercise could effectively elicit changes of the response inhibition in college students with smartphone addiction. 'e largest improvement was observed in the moderate intensity of an acute aerobic exercise in college students with smartphone addiction.