001492867 001__ 1492867
001492867 005__ 20240627003246.0
001492867 02470 $$ahttps://doi.org/10.3390/metabo13040545$$2DOI
001492867 037__ $$aIR
001492867 041__ $$aeng
001492867 245__ $$aMetabolic Inheritance and the Competition for Calories between Mother and Fetus
001492867 269__ $$a2023-04-11
001492867 520__ $$aDuring the prenatal period, maternal and fetal cells compete for calories and nutrients. To ensure the survival of the mother and development of the fetus, the prenatal hormonal milieu alters the competitive environment via metabolic perturbations (e.g., insulin resistance). These perturbations increase maternal caloric consumption and engender increments in both maternal fat mass and the number of calories captured by the fetus. However, a mother’s metabolic and behavioral phenotypes (e.g., physical activity levels) and her external environment (e.g., food availability) can asymmetrically impact the competitive milieu, leading to irreversible changes in pre- and post-natal development—as exhibited by stunting and obesity. Therefore, the interaction of maternal metabolism, behavior, and environment impact the competition for calories—which in turn creates a continuum of health trajectories in offspring. In sum, the inheritance of metabolic phenotypes offers a comprehensive and consilient explanation for much of the increase in obesity and T2DM over the past 50 years in human and non-human mammals.
001492867 6531_ $$amaternal
001492867 6531_ $$afetal
001492867 6531_ $$acompetition inheritance
001492867 6531_ $$ametabolism
001492867 6531_ $$aobsesity
001492867 6531_ $$aT2DM
001492867 7001_ $$aArcher, Edward$$u EvolvingFX LLC
001492867 7001_ $$aLavie, Carl  J.$$uThe University of Queensland School of Medicine
001492867 7001_ $$aDobersek, Urska$$uUniversity of Southern Indiana
001492867 7001_ $$aHill, James O.$$uUniversity of Alabama at Birmingham
001492867 773__ $$tMetabolites
001492867 8564_ $$9e87972cd-2449-4cb7-bed1-592989425476$$s838535$$uhttps://library.usi.edu/record/1492867/files/metabolites-13-00545.pdf
001492867 909CO $$ooai:library.usi.edu:1492867$$pGLOBAL_SET
001492867 980__ $$aMANUSCRIPT