TY  - GEN
AB  - Cell signaling is essential for individual cells to execute various tasks and respond to changes in their
environment. It is carried out via diffusing molecules, whose transport is often aided by directional advection.
How diffusion and advection together impact the accuracy of information transmission during signaling remains
poorly understood. Here, we study this problem using a simplified model of signal transport in the presence and
absence of crowding. Mutual information, our measure of accuracy, shows three distinct regimes characterized
by power-law decay. Surprisingly, crowding has no measurable effect on information transmission. Our results
provide several important insights into the role of transport in cell signaling.
AD  - Los Alamos National Laboratory
AD  - University of Massachusetts Chan Medical School
AD  - The Institute of Mathematical Sciences, CIT Campus
AU  - Sarkar, Sumantra
AU  - Ali, Md Zulfikar
AU  - Choubey, Sandeep
DA  - 2023-01-31
ID  - 1562300
JF  - Physical Review Research
L1  - https://library.usi.edu/record/1562300/files/PhysRevResearch.5.013092.pdf
L2  - https://library.usi.edu/record/1562300/files/PhysRevResearch.5.013092.pdf
L4  - https://library.usi.edu/record/1562300/files/PhysRevResearch.5.013092.pdf
LA  - eng
LK  - https://library.usi.edu/record/1562300/files/PhysRevResearch.5.013092.pdf
N1  - Efficacy of information transmission in cellular communication
Sumantra Sarkar, Md Zulfikar Ali, and Sandeep Choubey
Phys. Rev. Research 5, 013092 – Published 9 February 2023
N2  - Cell signaling is essential for individual cells to execute various tasks and respond to changes in their
environment. It is carried out via diffusing molecules, whose transport is often aided by directional advection.
How diffusion and advection together impact the accuracy of information transmission during signaling remains
poorly understood. Here, we study this problem using a simplified model of signal transport in the presence and
absence of crowding. Mutual information, our measure of accuracy, shows three distinct regimes characterized
by power-law decay. Surprisingly, crowding has no measurable effect on information transmission. Our results
provide several important insights into the role of transport in cell signaling.
PY  - 2023-01-31
T1  - Efficacy of information transmission in cellular communication
TI  - Efficacy of information transmission in cellular communication
UR  - https://library.usi.edu/record/1562300/files/PhysRevResearch.5.013092.pdf
Y1  - 2023-01-31
ER  -