001562300 001__ 1562300
001562300 005__ 20241015084421.0
001562300 02470 $$ahttps://doi.org/10.1103$$2DOI
001562300 037__ $$aIR
001562300 041__ $$aeng
001562300 245__ $$aEfficacy of information transmission in cellular communication
001562300 269__ $$a2023-01-31
001562300 500__ $$aEfficacy of information transmission in cellular communication
Sumantra Sarkar, Md Zulfikar Ali, and Sandeep Choubey
Phys. Rev. Research 5, 013092 – Published 9 February 2023
001562300 520__ $$aCell signaling is essential for individual cells to execute various tasks and respond to changes in their
environment. It is carried out via diffusing molecules, whose transport is often aided by directional advection.
How diffusion and advection together impact the accuracy of information transmission during signaling remains
poorly understood. Here, we study this problem using a simplified model of signal transport in the presence and
absence of crowding. Mutual information, our measure of accuracy, shows three distinct regimes characterized
by power-law decay. Surprisingly, crowding has no measurable effect on information transmission. Our results
provide several important insights into the role of transport in cell signaling.
001562300 7001_ $$aSarkar, Sumantra$$uLos Alamos National Laboratory
001562300 7001_ $$aAli, Md Zulfikar$$uUniversity of Massachusetts Chan Medical School
001562300 7001_ $$aChoubey, Sandeep$$uThe Institute of Mathematical Sciences, CIT Campus
001562300 773__ $$tPhysical Review Research
001562300 789__ $$whttps://journals.aps.org/prresearch/abstract/10.1103/PhysRevResearch.5.013092$$2URL
001562300 8564_ $$98d434e2f-6dd9-49df-bd6b-4c5740a2d654$$s934618$$uhttps://library.usi.edu/record/1562300/files/PhysRevResearch.5.013092.pdf
001562300 909CO $$ooai:library.usi.edu:1562300$$pGLOBAL_SET
001562300 980__ $$aMANUSCRIPT