Chromatin : Structure, function, and history / Randall H. Morse, Laboratory of Molecular Genetics, Wadsworth Center, NY State Department of Health, Albany, NY, United States; Department of Biomedical Sciences, UAlbany School of Public Health, Albany, NY, United States.

Intro
Chromatin: Structure, Function, and History
Copyright
Contents
Preface
Part 1: Chromatin structure
Chapter 1: Early history
1869-1950: Identification of nucleic acid and the ``dark ages ́́of chromatin research
Prelude to the nucleosome: 1950s and 1960s
A model for the nucleosome: A new era of chromatin biology begins
References
Chapter 2: The nucleosome unveiled
From model to structure: The nucleosome core particle
Size and shape
The path of the DNA
Histones in the nucleosome

The nucleosome unveiled: High-resolution structure of the core particle
References
Chapter 3: Chromatin compaction
Early observations
Factors influencing chromatin folding
Cations
Linker histones
Histone tails
The structure of compact chromatin
Compact chromatin in living cells
Chromosome architecture
Chromosome territories
Loops
Topologically associating domains or TADs
Liquid-liquid condensates
Heterochromatin
Heterochromatin in budding yeast
References
Chapter 4: Nucleosomes in context: Positioning, occupancy, and spacing
Overview

Rotational vs translational nucleosome positioning
Nucleosome spacing
Methods for determining nucleosome positioning
Local analysis of nucleosome positioning
Global analysis of nucleosome positioning
First studies of nucleosome positioning
Nucleosome positioning in vivo
Heterogeneity in nucleosome positioning: Single cell approaches
Mechanisms of nucleosome positioning
Role of DNA sequence
DNA bending and nucleosome positioning
Poly(dA)-poly(dT) tracts and nucleosome exclusion
Cis vs trans determinants of nucleosome positioning and occupancy

Factors that contribute to nucleosome organization in trans
Nucleosome-positioning proteins
Nucleosome-excluding proteins
Remodelers and nucleosome positioning
Barrier elements, nucleosome spacing, and chromatin remodelers
NDRs and ``fragile ́́nucleosomes
References
Chapter 5: Histones and variants
General considerations
Histone deposition and chromatin maturation following DNA replication
Histone chaperones
Histone variation: Early work
Sea urchins: Variant histones expressed during development
Other species
Evolution of the histones

Canonical histones: Nonallelic variants
Histone mutants
Specialized variants
H2A.Z
H2A.X
H2A.B and the short H2A variants
MacroH2A
CenH3
H3.3
References
Part 2: Chromatin function
Chapter 6: Chromatin remodeling
The SWI/SNF complex
Yeast genetics points to a chromatin remodeling machine
swi and sin mutants
snf and ssn mutants
spt mutants
Connections between swi, snf, and spt mutants and chromatin
The SWI/SNF complex as a chromatin remodeling machine
More remodeling machines
SWI/SNF in other species
BAF mutations and cancer
RSC: A close cousin of the SWI/SNF complex
Chapter 7: Histone modifications
Chapter 8: Chromatin and transcription.