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Table of Contents
Intro
front-matter
Table of Contents
Preface
1
Organic Bioelectronic Transistors: From Fundamental Investigation of Bio-Interfaces to Highly Performing Biosensors
1. Introduction
2. Organic Thin Film Transistors as highly performing bioelectronic sensors
2.1 OTFT operating principles
2.2 OTFT analytical biosensors with different configurations
2.3 Impact of biological recognition on TFT performance features
3. Integration of recognition elements
3.1 Strategies for recognition elements immobilization
3.1.1 Physical Immobilization
3.1.2 Covalent Immobilization
3.1.3 Bioaffinity Immobilization
3.2 Bulk and Surface Equilibrium Constants of Ligand-Receptor
4. OTFT devices with a biolayer between the gate dielectric and the organic semiconductor
4.1 Interfacial electronic effects in functional bio-layers integrated into OTFT
4.2 Structural and morphological characterization of functional biointelayers
4.3 FBI-OTFT based biosensing platforms
4.4 Organic bioelectronics probing conformational changes in surface confined proteins
Conclusions
References
2
Biosensing with Electrolyte Gated Organic Field Effect Transistors
1. Introduction
2. EGOFETs as sensors for life sciences
2.1 Target analytes and biorecognition elements employed to date in EGOFET biosensors
2.2 Why EGOFET as biosensors?
2.3 Recognition element immobilization in EGOFETs biosensors
3. EGOFET biosensors with functionalized OS/electrolyte interface
3.1 Immobilization of biorecognition element using OSCs with substituted main conjugated backbone
3.2 Interfacial modification of the OSC surface
3.3 Direct physisorption of biorecognition elements on bare OSC
4. EGOFET biosensors with functionalized gate/electrolyte interface
5. EGOFET biosensors based on competitive binding.
Conclusions and future perspectives
References
3
The Organic Charge-Modulated Field-Effect Transistor: a Flexible Platform for Application in Biomedical Analyses
1. Introduction
2. Organic Charge-Modulated Field-Effect Transistor: device structure and working principle
3. OCMFET as sensor for biomedical applications
3.1 DNA sensing
3.2 Cellular electrical and pH sensing
Conclusions
References
4
Graphene Based Field Effect Transistors for Biosensing: Importance of Surface Modification
1. Introduction
1.1 From MOSFET to bioFET
1.2 From bioFET to GFET for sensing
2. Preparation of graphene, graphene oxide and reduced graphene and its transfer to surfaces for the formation of GFETs
3. Different graphene based transistor structures
4. Integration of surface ligands onto GFET for selective sensing
4.1 Non-covalent modification of graphene
4.2 Covalent modification of graphene
5. Applications of GFETs for sensing of biomolecules
5.1 DNA sensors
5.2 Protein sensors
5.3 Other molecules
5.4 Cells and bacteria
Conclusion and Perspectives
Acknowledgements
References
5
Graphene as an Organic and Bioelectronic Material
1. Introduction
2. Bioelectronic devices based on graphene
2.1 Graphene transistors
2.2 Graphene microelectrodes
3. Graphene devices for healthcare
3.1 GFET biosensing
3.2 GFET electrophysiology
3.3 GMEA electrophysiology
4. Towards flexible bioelectronics
5. Conclusions and outlook
References
6
Graphene based Materials for Bioelectronics and Healthcare
1. Graphene based materials
2. Syntheses of graphene based materials
3. Surface (bio)functionalization of GBMs
4. System integration of GBMs
5. Biosensor platforms of GBMs
6. Biosensor platforms of GBMs: Applications in healthcare.
7. Challenges and opportunities
References
7
Inkjet Printing for Biosensors and Bioelectronics
1. Introduction
2. Biosensor
3. Bioelectronic Interfaces:
Summary
References
8
Rapid Point-of-Care-Tests for Stroke Monitoring
1. Introduction
1.1 Stroke prognosis: what is missing?
1.2 Time is Brain: need for rapid solutions
1.3 Rapid Point-of-Care-Tests
2. POCTs Expedite Stroke Prognosis
2.1 Mobile Stroke Unit
2.2 Imaging POCTS
2.2.1 CereTom® (Samsung/Neurologica) &
SOMATOM Scope (Siemens)
2.2.2 Vivid q® (GE Healthcare)
2.3 Electrochemical POCTs Assays
2.3.1 CoaguChek® (Roche)
2.3.2 SMARTChip (Sarissa Biomedical)
2.3.3 i-STAT® (Abbott)
2.3.4 PocH-100iTM (Sysmex)
2.4 Optical POCTs Assays
2.4.1 Hemochron® (ITC/Accriva Diagnostics)
2.4.2 Reflotron® plus analyzer (Roche)
2.4.3 Cobas® h 232 (Roche)
2.4.4 Triage® BNP Test (Alere)
2.4.4 Cornell University
2.4.5 VerifyNow® (Accumetrics/Accriva Diagnostics)
2.5 Other POCTs
2.5.4 PFA-100® (Dade/Siemens)
2.5.2 Prediction Sciences LLC
2.5.3 ReST™ (Valtari BioTM Inc.)
3. Future Stroke POCTs
Acknowledgments
References
back-matter
Conclusions and Outlook
Keyword Index
About the Editors.
front-matter
Table of Contents
Preface
1
Organic Bioelectronic Transistors: From Fundamental Investigation of Bio-Interfaces to Highly Performing Biosensors
1. Introduction
2. Organic Thin Film Transistors as highly performing bioelectronic sensors
2.1 OTFT operating principles
2.2 OTFT analytical biosensors with different configurations
2.3 Impact of biological recognition on TFT performance features
3. Integration of recognition elements
3.1 Strategies for recognition elements immobilization
3.1.1 Physical Immobilization
3.1.2 Covalent Immobilization
3.1.3 Bioaffinity Immobilization
3.2 Bulk and Surface Equilibrium Constants of Ligand-Receptor
4. OTFT devices with a biolayer between the gate dielectric and the organic semiconductor
4.1 Interfacial electronic effects in functional bio-layers integrated into OTFT
4.2 Structural and morphological characterization of functional biointelayers
4.3 FBI-OTFT based biosensing platforms
4.4 Organic bioelectronics probing conformational changes in surface confined proteins
Conclusions
References
2
Biosensing with Electrolyte Gated Organic Field Effect Transistors
1. Introduction
2. EGOFETs as sensors for life sciences
2.1 Target analytes and biorecognition elements employed to date in EGOFET biosensors
2.2 Why EGOFET as biosensors?
2.3 Recognition element immobilization in EGOFETs biosensors
3. EGOFET biosensors with functionalized OS/electrolyte interface
3.1 Immobilization of biorecognition element using OSCs with substituted main conjugated backbone
3.2 Interfacial modification of the OSC surface
3.3 Direct physisorption of biorecognition elements on bare OSC
4. EGOFET biosensors with functionalized gate/electrolyte interface
5. EGOFET biosensors based on competitive binding.
Conclusions and future perspectives
References
3
The Organic Charge-Modulated Field-Effect Transistor: a Flexible Platform for Application in Biomedical Analyses
1. Introduction
2. Organic Charge-Modulated Field-Effect Transistor: device structure and working principle
3. OCMFET as sensor for biomedical applications
3.1 DNA sensing
3.2 Cellular electrical and pH sensing
Conclusions
References
4
Graphene Based Field Effect Transistors for Biosensing: Importance of Surface Modification
1. Introduction
1.1 From MOSFET to bioFET
1.2 From bioFET to GFET for sensing
2. Preparation of graphene, graphene oxide and reduced graphene and its transfer to surfaces for the formation of GFETs
3. Different graphene based transistor structures
4. Integration of surface ligands onto GFET for selective sensing
4.1 Non-covalent modification of graphene
4.2 Covalent modification of graphene
5. Applications of GFETs for sensing of biomolecules
5.1 DNA sensors
5.2 Protein sensors
5.3 Other molecules
5.4 Cells and bacteria
Conclusion and Perspectives
Acknowledgements
References
5
Graphene as an Organic and Bioelectronic Material
1. Introduction
2. Bioelectronic devices based on graphene
2.1 Graphene transistors
2.2 Graphene microelectrodes
3. Graphene devices for healthcare
3.1 GFET biosensing
3.2 GFET electrophysiology
3.3 GMEA electrophysiology
4. Towards flexible bioelectronics
5. Conclusions and outlook
References
6
Graphene based Materials for Bioelectronics and Healthcare
1. Graphene based materials
2. Syntheses of graphene based materials
3. Surface (bio)functionalization of GBMs
4. System integration of GBMs
5. Biosensor platforms of GBMs
6. Biosensor platforms of GBMs: Applications in healthcare.
7. Challenges and opportunities
References
7
Inkjet Printing for Biosensors and Bioelectronics
1. Introduction
2. Biosensor
3. Bioelectronic Interfaces:
Summary
References
8
Rapid Point-of-Care-Tests for Stroke Monitoring
1. Introduction
1.1 Stroke prognosis: what is missing?
1.2 Time is Brain: need for rapid solutions
1.3 Rapid Point-of-Care-Tests
2. POCTs Expedite Stroke Prognosis
2.1 Mobile Stroke Unit
2.2 Imaging POCTS
2.2.1 CereTom® (Samsung/Neurologica) &
SOMATOM Scope (Siemens)
2.2.2 Vivid q® (GE Healthcare)
2.3 Electrochemical POCTs Assays
2.3.1 CoaguChek® (Roche)
2.3.2 SMARTChip (Sarissa Biomedical)
2.3.3 i-STAT® (Abbott)
2.3.4 PocH-100iTM (Sysmex)
2.4 Optical POCTs Assays
2.4.1 Hemochron® (ITC/Accriva Diagnostics)
2.4.2 Reflotron® plus analyzer (Roche)
2.4.3 Cobas® h 232 (Roche)
2.4.4 Triage® BNP Test (Alere)
2.4.4 Cornell University
2.4.5 VerifyNow® (Accumetrics/Accriva Diagnostics)
2.5 Other POCTs
2.5.4 PFA-100® (Dade/Siemens)
2.5.2 Prediction Sciences LLC
2.5.3 ReST™ (Valtari BioTM Inc.)
3. Future Stroke POCTs
Acknowledgments
References
back-matter
Conclusions and Outlook
Keyword Index
About the Editors.