Stem Cells in Clinical Application and Productization.

Cover
Title
Copyright
End User License Agreement
Contents
Foreword
Preface
List of Contributors
The Historical Overview of Stem Cells
Leisheng Zhang1,2,3,4,*, #, Hao Yu5,6,7,#, Wenjing Du5,6,7,#, Shuang Chen8, Yuan- guang Zhao8, Jun Yao9,* and Cunrong Chen10,*
INTRODUCTION
THE DEFINITION AND HISTORY OF STEM CELLS
THE CHARACTERISTICS AND BIOLOGY OF STEM CELLS
THE CLASSIFICATION OF STEM CELLS
THE SAFETY AND EFFICACY OF STEM CELLS
CONCLUSION
ABBREVIATIONS
ACKNOWLEDGEMENTS
REFERENCES
Biomaterials and Stem Cells
Leisheng Zhang1,2,3,4,*, #, Xiaodong Xu5,#, Rucai Zhan6,#, Shuang Chen7, Shixun Ma1, Yuanguang Zhao7, Zhihai Han3, Xianghong Xu1, Yonghong Li1, Miao Yu1, Tiankang Guo1, Hui Cai1, Hao Yao8,* and Ping Wang9,*
INTRODUCTION
HYDROGEL/STEM CELL COMPOSITE
COLLAGEN SCAFFOLD/STEM CELL COMPOSITE
NANOMATERIALS/STEM CELL COMPOSITE
BIOMATERIALS AND DERIVATIVES OF STEM CELLS
CONCLUSION
LIST OF ABBREVIATIONS
ACKNOWLEDGEMENTS
REFERENCES
Hematopoietic Stem Cells in Regenerative Medicine
Leisheng Zhang1,2,3,4,*, #, Xiaorong Bai5,#, Shan Huang6,#, Jiechao Ma7, Yuan Meng8, Xiaoming Feng9, Tiankang Guo1,* and Hui Cai1,*
INTRODUCTION
THE OVERVIEW OF HEMATOPOIETIC STEM CELLS (HSCS)
THE ORIGINS AND DEVELOPMENT OF HSCS
THE PRECLINICAL AND CLINICAL APPLICATIONS OF HSCS
CONCLUSION
LIST OF ABBREVIATIONS
ACKNOWLEDGEMENTS
REFERENCES
Neural Stem Cells in Tissue Engineering
Leisheng Zhang1,2,3,4,*, #, Xiaowei Gao5,#, Hongjun Chen6, Yimeng Wei7, Ping Wang8,* and Chaohui Zheng9,*
INTRODUCTION
THE OVERVIEW OF NEURAL STEM CELLS (NSCS)
THE ORIGINS AND DEVELOPMENT OF NSCS
THE APPLICATION OF NSCS AND THE UNDERLYING MOLECULAR MECHANISM
CONCLUSION
LIST OF ABBREVIATIONS
ACKNOWLEDGEMENTS
REFERENCES
Biomaterials and Mesenchymal Stem Cells.

Leisheng Zhang1,2,3,4,*, #, Bin Li5,#, Hao Yao6,#, Zongjin Li7 and Chenxi Ouyang8,*
INTRODUCTION
THE BIOLOGICAL PROPERTIES OF MSCS
THE ORIGINS AND DEVELOPMENT OF MSCS
THE APPLICATION AND MOLECULAR MECHANISM OF MSCS
THE STANDARDIZATION AND INDUSTRIALIZATION OF MSCS
CONCLUSION
LIST OF ABBREVIATIONS
ACKNOWLEDGEMENTS
REFERENCES
Stem Cells-Based Technological Innovation in Tissue Engineering
Leisheng Zhang1,2,3,4,*, #, Dong Zhang5,#, Wenjing Miao6,#, Zhihai Han3, Xian- ghong Xu1, Hongju Yang6,* and Baoquan Song7,*
INTRODUCTION
THREE-DIMENSIONAL (3D) PRINTING
ORGANOID
GENE EDITING AND STEM CELL-BASED GENE THERAPY
IN VIVO FLUORESCENT TRACER
SINGLE-CELL RNA SEQUENCING (SCRNA-SEQ)
CONCLUSION
LIST OF ABBREVIATIONS
ACKNOWLEDGEMENTS
REFERENCES
MSCs as Biological Drugs: From Manufacturing to Commercialization
Hao Yu1,2,3,#, Xiaonan Yang4,5,#, Meng Zhao2,3 and Leisheng Zhang6,7,8,9,*
INTRODUCTION
PROCESS DEVELOPMENT OF MESENCHYMAL STEM CELLS PRODUCTS
CHEMISTRY, MANUFACTURING, AND CONTROLS (GMP)
Raw Materials and Excipients
Raw Materials
Excipients
Process
Quality Research and Quality Control
Stability Studies of MSC Products
Packaging and Closed Container Systems
PHARMACOLOGICAL AND TOXICOLOGICAL STUDIES (GLP)
MESENCHYMAL STEM CELLS: CLINICAL TRIALS (GCP)
MSC-BASED PRODUCTS IN THE MARKET
REGULATIONS AND GUIDANCE OF MSC PRODUCTS
CONCLUSION
ACKNOWLEDGEMENTS
REFERENCES
Subject Index
Back Cover.