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Table of Contents
Intro
Preface
Acknowledgments
Editor biographies
Raju Khan
Ayushi Singhal
List of contributors
Chapter 1 An introduction to molecularly imprinted polymers: the plastic antibodies
1.1 Introduction
1.2 The early history of MIPs
1.3 MIPs compared to other biorecognition elements
1.4 The properties of MIPs
1.5 The applications of MIPs in various fields
1.5.1 Environmental applications
1.5.2 Food analysis
1.5.3 Biomedical diagnostics
1.5.4 Drug delivery
1.6 Challenges
1.7 Conclusion and future prospects
References
Chapter 2 Synthesis and characterization of molecularly imprinted polymers
2.1 Synthesis of imprinted polymers
2.1.1 Imprinted polymers from monomers
2.1.2 Imprinted polymers from polymers
2.1.3 Imprinted polymers from co-blocks
2.1.4 Initiator assisted synthesis
2.1.5 Flexible imprinted polymers
2.1.6 Resist modified imprinted polymers
2.2 Surface characterization techniques for MIPs
2.2.1 FTIR spectroscopy
2.2.2 NMR spectroscopy
2.2.3 Chromatography
2.2.4 BET analysis
2.2.5 TGA
2.2.6 Isotherms governing MIPs
2.2.7 SEM and TEM analysis
2.3 Applications of imprinted polymers
2.4 Challenges in synthesizing imprinted polymers
References
Chapter 3 Theoretical and computational approaches and strategies in molecularly imprinted polymer development
3.1 Introduction
3.2 Molecular imprinting technology
3.2.1 The physical forms of imprinted polymers
3.2.2 Target molecules and applications
3.3 Theoretical and computational strategies for MIP development
3.3.1 Electronic structure calculations
3.3.2 Molecular dynamics
3.3.3 Multivariate analysis
3.4 The pre-polymerization stage
3.4.1 Electronic structure calculations
3.4.2 Molecular dynamics
3.4.3 Multivariate analysis
3.5 The polymerization stage.
3.5.1 Electronic structure calculations
3.5.2 Molecular dynamics
3.5.3 Multivariate analysis
3.6 MIP structure and function
3.6.1 Electronic structure calculations
3.6.2 Molecular dynamics
3.6.3 Multivariate analysis
3.7 Conclusions and perspectives
References
Chapter 4 The role of nanomaterials in molecularly imprinted polymers for disease diagnosis
4.1 Fundamentals of nanomaterials in molecularly imprinted polymers (MIPs)
4.2 MIP sensors for disease diagnosis purposes
4.3 Assembled nanomaterials on MIPs for improved disease diagnosis purposes
4.3.1 Electrochemical sensors
4.3.2 Optical sensors
4.4 Conclusion, challenges, and prospects
References
Chapter 5 Current and emerging techniques for the detection of environmental contaminants
5.1 Introduction
5.2 Existing techniques for the detection of environmental contaminants
5.3 Electrochemical detection of contaminants
5.4 Optical detection
5.5 Fluorescent detection
5.6 Future perspectives
Acknowledgments
References
Chapter 6 The importance of molecularly imprinted polymers in wastewater treatment
6.1 Introduction
6.2 The significance of MIPs in wastewater treatment
6.3 Literature review of MIPs for wastewater treatment
6.4 Current status and future prospects
6.5 Conclusion
Funding statement
Conflicts of interest
References
Chapter 7 Molecularly imprinted polymers for the detection of heavy metals
7.1 Introduction
7.1.1 Heavy metals
7.1.2 Biomimetics: methods of detection
7.1.3 Polymers to molecular-imprinted polymers
7.2 Molecularly imprinted polymers
7.3 MIP-based sensing and removal of heavy metals
7.3.1 Mercury (II) ions
7.3.2 Lead (II) ions
7.3.3 Cadmium (II) ions
7.3.4 Chromium (III) ions
7.3.5 Copper (II) ions
7.3.6 Arsenic ions
7.3.7 Selenium ions.
7.3.8 Iron (II) ions
7.3.9 Nickel (II) ions
7.4 Transformed MIP-based detection
7.5 Future prospects of MIPs in toxicity remediation
7.6 Conclusion
References
Chapter 8 Molecularly imprinted polymers for the extraction and sensing of vitamins
8.1 Overview of molecular imprinting
8.2 Imprinted polymers for vitamins
8.2.1 Water-soluble vitamins
8.2.2 MIPs against fat-soluble vitamins
8.3 Future perspective
References
Chapter 9 Molecularly imprinted polymers for the detection of toxic anions
9.1 Introduction
9.2 Molecularly imprinted polymer constituents, technologies, and strategies
9.2.1 The different components of MIPs
9.2.2 Molecular imprinting technologies (MITs)
9.2.3 Strategies and approaches
9.3 Molecular imprinting for anion recognition
9.3.1 Sensing of inorganic anions
9.3.2 Sensing of organic anions
9.4 Conclusion and outlook
References
Chapter 10 Molecularly imprinted polymers for the detection of environmental estrogens
10.1 Introduction
10.1.1 What are environmental estrogens?
10.2 Overview of molecularly imprinted polymers
10.3 The preparation of MIP-based chemical sensors
10.4 Types of MIP-based chemical sensors
10.4.1 MIP-based electrochemical sensors
10.4.2 MIP-based optical sensors
10.4.3 MIP-based quartz crystal microbalance sensors
10.4.4 MIP-based thermal sensors
10.5 Application of MIP-based sensors in the analysis of EEs
10.5.1 Detection of natural estrogens in the environment
10.5.2 Detection of synthetic environmental estrogens
10.5.3 Persistent organic pollutants
10.5.4 Phthalates
10.6 Conclusion and future perspectives
Acknowledgments
References
Chapter 11 Molecularly imprinted polymer based detection of pesticides
11.1 Introduction
11.2 General concepts of MIPs.
11.3 The synthesis procedure for MIPs
11.4 MIPs as recognition elements for electrochemical sensors
11.5 The development of MIP-based electrochemical sensors
11.6 Electrochemical techniques combined with MIP sensors
11.6.1 Voltammetric detection
11.6.2 Amperometric detection
11.6.3 Electrochemical impedance spectroscopic detection
11.6.4 Potentiometric detection
11.7 Recent advances of MIP-based electrochemical sensors for pesticide detection
11.7.1 Pesticides
11.7.2 Insecticides
11.7.3 Herbicides
11.7.4 Fungicides and biocides
11.8 Challenges and limitations of MIP application in pesticide detection
11.9 Conclusion and future perspectives
References
Chapter 12 Molecularly imprinted polymers for the detection of pharmaceutical residues
12.1 Introduction
12.2 MIPs-artificial antibodies
12.3 MIPs-life-saving tools
12.4 MIP-based sensors for the detection of pharmaceutical residues
12.5 Conclusion and future perspectives
Acknowledgements
References
Chapter 13 Molecularly imprinted polymers for the sensing of microorganisms
13.1 Introduction
13.2 Detection of microorganisms
13.3 Traditional methods of detection and analysis
13.4 Emerging methods for detection and selective methods of recognition
13.5 Electrochemical based detection
13.6 Fluorescence based detection
13.7 Surface plasmon resonance based detection
13.8 Quartz crystal microbalance-based detection
13.9 Conclusion and future perspectives
Acknowledgements
References
Chapter 14 Future perspectives on molecularly imprinted polymers for environmental monitoring
14.1 Introduction
14.2 Molecular imprinting for environmental monitoring
14.3 Pre-polymerization studies
14.4 Green aspects in molecularly imprinted microspheres
14.5 The detection of contaminants using MIPs.
14.6 MIPs for microbial contaminants
14.7 MIPs for water contaminants
14.8 Electrochemical biosensors
14.9 MIP nanoparticles
14.10 Conclusions
References.
Preface
Acknowledgments
Editor biographies
Raju Khan
Ayushi Singhal
List of contributors
Chapter 1 An introduction to molecularly imprinted polymers: the plastic antibodies
1.1 Introduction
1.2 The early history of MIPs
1.3 MIPs compared to other biorecognition elements
1.4 The properties of MIPs
1.5 The applications of MIPs in various fields
1.5.1 Environmental applications
1.5.2 Food analysis
1.5.3 Biomedical diagnostics
1.5.4 Drug delivery
1.6 Challenges
1.7 Conclusion and future prospects
References
Chapter 2 Synthesis and characterization of molecularly imprinted polymers
2.1 Synthesis of imprinted polymers
2.1.1 Imprinted polymers from monomers
2.1.2 Imprinted polymers from polymers
2.1.3 Imprinted polymers from co-blocks
2.1.4 Initiator assisted synthesis
2.1.5 Flexible imprinted polymers
2.1.6 Resist modified imprinted polymers
2.2 Surface characterization techniques for MIPs
2.2.1 FTIR spectroscopy
2.2.2 NMR spectroscopy
2.2.3 Chromatography
2.2.4 BET analysis
2.2.5 TGA
2.2.6 Isotherms governing MIPs
2.2.7 SEM and TEM analysis
2.3 Applications of imprinted polymers
2.4 Challenges in synthesizing imprinted polymers
References
Chapter 3 Theoretical and computational approaches and strategies in molecularly imprinted polymer development
3.1 Introduction
3.2 Molecular imprinting technology
3.2.1 The physical forms of imprinted polymers
3.2.2 Target molecules and applications
3.3 Theoretical and computational strategies for MIP development
3.3.1 Electronic structure calculations
3.3.2 Molecular dynamics
3.3.3 Multivariate analysis
3.4 The pre-polymerization stage
3.4.1 Electronic structure calculations
3.4.2 Molecular dynamics
3.4.3 Multivariate analysis
3.5 The polymerization stage.
3.5.1 Electronic structure calculations
3.5.2 Molecular dynamics
3.5.3 Multivariate analysis
3.6 MIP structure and function
3.6.1 Electronic structure calculations
3.6.2 Molecular dynamics
3.6.3 Multivariate analysis
3.7 Conclusions and perspectives
References
Chapter 4 The role of nanomaterials in molecularly imprinted polymers for disease diagnosis
4.1 Fundamentals of nanomaterials in molecularly imprinted polymers (MIPs)
4.2 MIP sensors for disease diagnosis purposes
4.3 Assembled nanomaterials on MIPs for improved disease diagnosis purposes
4.3.1 Electrochemical sensors
4.3.2 Optical sensors
4.4 Conclusion, challenges, and prospects
References
Chapter 5 Current and emerging techniques for the detection of environmental contaminants
5.1 Introduction
5.2 Existing techniques for the detection of environmental contaminants
5.3 Electrochemical detection of contaminants
5.4 Optical detection
5.5 Fluorescent detection
5.6 Future perspectives
Acknowledgments
References
Chapter 6 The importance of molecularly imprinted polymers in wastewater treatment
6.1 Introduction
6.2 The significance of MIPs in wastewater treatment
6.3 Literature review of MIPs for wastewater treatment
6.4 Current status and future prospects
6.5 Conclusion
Funding statement
Conflicts of interest
References
Chapter 7 Molecularly imprinted polymers for the detection of heavy metals
7.1 Introduction
7.1.1 Heavy metals
7.1.2 Biomimetics: methods of detection
7.1.3 Polymers to molecular-imprinted polymers
7.2 Molecularly imprinted polymers
7.3 MIP-based sensing and removal of heavy metals
7.3.1 Mercury (II) ions
7.3.2 Lead (II) ions
7.3.3 Cadmium (II) ions
7.3.4 Chromium (III) ions
7.3.5 Copper (II) ions
7.3.6 Arsenic ions
7.3.7 Selenium ions.
7.3.8 Iron (II) ions
7.3.9 Nickel (II) ions
7.4 Transformed MIP-based detection
7.5 Future prospects of MIPs in toxicity remediation
7.6 Conclusion
References
Chapter 8 Molecularly imprinted polymers for the extraction and sensing of vitamins
8.1 Overview of molecular imprinting
8.2 Imprinted polymers for vitamins
8.2.1 Water-soluble vitamins
8.2.2 MIPs against fat-soluble vitamins
8.3 Future perspective
References
Chapter 9 Molecularly imprinted polymers for the detection of toxic anions
9.1 Introduction
9.2 Molecularly imprinted polymer constituents, technologies, and strategies
9.2.1 The different components of MIPs
9.2.2 Molecular imprinting technologies (MITs)
9.2.3 Strategies and approaches
9.3 Molecular imprinting for anion recognition
9.3.1 Sensing of inorganic anions
9.3.2 Sensing of organic anions
9.4 Conclusion and outlook
References
Chapter 10 Molecularly imprinted polymers for the detection of environmental estrogens
10.1 Introduction
10.1.1 What are environmental estrogens?
10.2 Overview of molecularly imprinted polymers
10.3 The preparation of MIP-based chemical sensors
10.4 Types of MIP-based chemical sensors
10.4.1 MIP-based electrochemical sensors
10.4.2 MIP-based optical sensors
10.4.3 MIP-based quartz crystal microbalance sensors
10.4.4 MIP-based thermal sensors
10.5 Application of MIP-based sensors in the analysis of EEs
10.5.1 Detection of natural estrogens in the environment
10.5.2 Detection of synthetic environmental estrogens
10.5.3 Persistent organic pollutants
10.5.4 Phthalates
10.6 Conclusion and future perspectives
Acknowledgments
References
Chapter 11 Molecularly imprinted polymer based detection of pesticides
11.1 Introduction
11.2 General concepts of MIPs.
11.3 The synthesis procedure for MIPs
11.4 MIPs as recognition elements for electrochemical sensors
11.5 The development of MIP-based electrochemical sensors
11.6 Electrochemical techniques combined with MIP sensors
11.6.1 Voltammetric detection
11.6.2 Amperometric detection
11.6.3 Electrochemical impedance spectroscopic detection
11.6.4 Potentiometric detection
11.7 Recent advances of MIP-based electrochemical sensors for pesticide detection
11.7.1 Pesticides
11.7.2 Insecticides
11.7.3 Herbicides
11.7.4 Fungicides and biocides
11.8 Challenges and limitations of MIP application in pesticide detection
11.9 Conclusion and future perspectives
References
Chapter 12 Molecularly imprinted polymers for the detection of pharmaceutical residues
12.1 Introduction
12.2 MIPs-artificial antibodies
12.3 MIPs-life-saving tools
12.4 MIP-based sensors for the detection of pharmaceutical residues
12.5 Conclusion and future perspectives
Acknowledgements
References
Chapter 13 Molecularly imprinted polymers for the sensing of microorganisms
13.1 Introduction
13.2 Detection of microorganisms
13.3 Traditional methods of detection and analysis
13.4 Emerging methods for detection and selective methods of recognition
13.5 Electrochemical based detection
13.6 Fluorescence based detection
13.7 Surface plasmon resonance based detection
13.8 Quartz crystal microbalance-based detection
13.9 Conclusion and future perspectives
Acknowledgements
References
Chapter 14 Future perspectives on molecularly imprinted polymers for environmental monitoring
14.1 Introduction
14.2 Molecular imprinting for environmental monitoring
14.3 Pre-polymerization studies
14.4 Green aspects in molecularly imprinted microspheres
14.5 The detection of contaminants using MIPs.
14.6 MIPs for microbial contaminants
14.7 MIPs for water contaminants
14.8 Electrochemical biosensors
14.9 MIP nanoparticles
14.10 Conclusions
References.