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Table of Contents
Intro
Foreword
Author biographies
Rishabha Malviya
Deepika Yadav
Sonali Sundram
Seifedine Kadry
Gurvinder Singh Virk
About the book
Chapter Nanorobotics: materials, design, and technology
1.1 Introduction
1.2 Nanorobot design and development
1.3 Nanorobots designed for a broad spectrum of healthcare uses
1.4 The applications of nanorobots in the field of biomedicine
1.4.1 Microbiology
1.4.2 Cancer therapy using nanorobots
1.4.3 Biologically inspired nanorobots
1.4.4 The prospects of nanorobots for use in hematology
1.4.5 The neurosurgical prospects of nanorobots
1.5 The prospects of nanorobots for use in dentistry
1.6 The use of nanorobots in gene therapy
1.7 The biocompatibility and toxicity of nanorobots
1.8 Conclusions
References and further reading
Chapter Robotics and biophysics: technology advances and challenges in organic and inorganic domains
2.1 Introduction
2.2 An introduction to the use of robots in the field of biophysics
2.2.1 The importance of robots in the field of biophysical research
2.2.2 The possible application of robots in areas of biophysical investigation
2.2.3 Biophysical applications of robot-based systems
2.3 Technology advances of soft robotics in the organic domain
2.3.1 The applications of soft robots in medical and biological settings
2.3.2 Biomimetic design
2.3.3 The benefits of biomimetic design in biophysics
2.3.4 The challenges of applying biomimetic design principles in the field of biophysics
2.4 Developments in inorganic measurement technology
2.4.1 The integration of advanced prosthetic limbs and biophysics
2.4.2 Robotics in diagnostic imaging and laboratory tasks
2.5 Challenges in integration
2.5.1 Ethical and regulatory issues.
2.5.2 Regulatory challenges in the development of biophysics-based robotic systems
2.5.3 Interdisciplinary collaboration
2.6 Future prospects
2.7 Conclusions
References
Chapter Nanorobots: a primer for deciphering the biophysics of cancer
3.1 Introduction
3.2 Multiscale cancer biophysics
3.3 The biology of cancer cells
3.4 The reason for a biophysical strategy for cancer
3.5 Nanorobots
3.6 Nanorobots for the detection and treatment of cancer
3.7 Conclusions
References and further reading
Chapter The biophysics of cancer: management at the nanoscale
4.1 Introduction
4.2 Important aspects of nanorobots for cancer therapy
4.3 Nanorobot propulsion systems for anticancer medicine delivery
4.3.1 Nanorobots propelled by magnets
4.3.2 Nanorobots propelled by ultrasound
4.3.3 Biologically propelled nanorobots
4.3.4 Hybrid-drive nanorobots
4.3.5 Nanorobots propelled by other power sources
4.4 Precision cancer diagnosis and treatment with nanorobots
4.4.1 The identification and assessment of cancerous conditions
4.4.2 Gene therapy involving the precise administration of nucleic DNA
4.4.3 Vascular infarction in tumors
4.5 Nanorobots in cancer therapy: potential and clinical problems
4.5.1 The complexity and accuracy of the technology
4.5.2 Concerns regarding personal safety
4.5.3 Regulatory concerns
4.5.4 Scalability
4.5.5 Cost
4.5.6 Quality control
4.5.7 Management of the supply chain and its components
4.6 Future perspectives and conclusions
References
Chapter Magnetomechanical systems at the micro/nanoscale for cancer management
5.1 Introduction
5.2 Cancer therapy using magnetomechanical particles
5.2.1 Principle
5.3 The magnetomechanical identification of telomerase and nuclear acids in cancerous cells.
5.4 The therapeutic applications of telomerase studies in cancer
5.5 The clinical applications of telomeres and telomerase in oncology
5.6 Conclusions
Funding
Conflict of interest
References
Chapter The role of micro/nanorobotics in personalized healthcare
6.1 Introduction
6.2 Surgical operations
6.2.1 Biopsy and sample collection
6.2.2 The invasion or penetration of tissues
6.2.3 The breakdown of biofilms
6.2.4 Deliveries conducted within cells
6.3 Diagnosis
6.3.1 Biological sensors
6.3.2 Isolation
6.3.3 Physical sensors
6.4 Imaging and diagnostic medicine
6.4.1 Optical imaging
6.4.2 Imaging using ultrasound
6.4.3 Imaging using radionuclides
6.5 Prospective view
6.6 Regulatory challenges in personalized healthcare
6.7 Conclusions
References and further reading
Chapter The development of active nanorobots in personalized healthcare
7.1 Introduction
7.2 Nanorobots
7.3 Nanorobots in healthcare
7.3.1 Helices
7.3.2 Nanorods
7.3.3 DNA nanorobots
7.4 Applications of nanorobots in personalized healthcare
7.4.1 The use of nanorobots in dentistry
7.4.2 The use of nanorobots in cancer treatment
7.4.3 The application of nanorobots in the treatment and diagnosis of diabetes
7.4.4 The application of nanorobots in neurology
7.4.5 The application of nanorobots in hematology
7.5 Future perspectives
7.6 Conclusions
References
Chapter Nanozyme-based nanorobots for cancer treatment applications
8.1 Introduction
8.2 Nanomedicine and nanotheranostics
8.3 Targeted tumor vessel infarction with nanomedicine
8.4 Targeted tumor drug delivery systems
8.4.1 Passively targeted drug delivery systems
8.4.2 Actively targeted medication delivery systems
8.5 Micro- and nanorobots
8.5.1 Chemically powered micro- and nanorobots.
8.5.2 External-field-powered micro- and nanorobots
8.5.3 Biohybrid micro- and nanorobots
8.6 Difficulties with cancer nanomedicines
8.7 Future perspectives
8.8 Conclusions
References
Chapter Progress in the bioelectrochemical and biophysical diagnostic profiling of malignant cancer cells
9.1 Introduction
9.2 The use of biosensors in clinical assessment
9.3 Electrochemical biosensors
9.3.1 Various electrochemical measurement methods
9.4 Conventional apoptotic and metastatic cell detection methods
9.5 Bioelectricity in cancer processes
9.5.1 Cancer and ion channels
9.5.2 Calcium channels
9.5.3 Sodium channels
9.5.4 Intracellular potassium channels
9.5.5 Chloride channels
9.5.6 Piezoelectric channels
9.6 The detection of bioelectric characteristics
9.7 Bioelectrical modifications
9.8 Electrification and extracellular vesicles
9.9 Biosensors for in vitro cancer cell assessment
9.10 Conclusions
References and further reading
Chapter Wireless microrobots: the next frontier in medical advancements
10.1 Introduction
10.2 Microrobots and their potential therapeutic applications
10.2.1 The imaging of functional capabilities for disorder diagnosis
10.2.2 Mobile situational awareness for disease diagnosis and health management
10.3 Targeted therapy
10.4 The applications of microrobotics in medicine, particularly in the human cardiovascular system and the bloodstream
10.5 Biomechanical restrictions that impede microrobots
10.6 Current challenges facing miniaturized biomedical robots and their potential future applications
10.7 Methods for the actuation and control of therapeutic microrobots
10.8 Conclusions
References and further reading
Chapter Revolutionizing cancer treatment using micro/nanorobotic devices
11.1 Introduction.
11.2 Nano/microrobots for drug delivery
11.3 Cancer-targeted drug delivery systems
11.3.1 Enhancing treatment precision using passive drug delivery
11.3.2 Enhancing treatment precision using active drug targeting
11.3.3 Surgical advancements with micro/nanorobotic assistance
11.3.4 Robotic biosensing
11.3.5 Enhancing drug delivery with micro/nanorobot mobility
11.3.6 Field-guided micro/nanorobotics
11.4 Conclusions and prospects
References and further reading
Chapter Cyborgs and cyberorgans: biosecurity in biorobotics for healthcare-a case study
12.1 Introduction
12.2 Biorobotics in healthcare
12.3 Cyborgs and cyberorgans in healthcare
12.4 Case study
12.5 Patent list
12.6 Conclusions
References.
Foreword
Author biographies
Rishabha Malviya
Deepika Yadav
Sonali Sundram
Seifedine Kadry
Gurvinder Singh Virk
About the book
Chapter Nanorobotics: materials, design, and technology
1.1 Introduction
1.2 Nanorobot design and development
1.3 Nanorobots designed for a broad spectrum of healthcare uses
1.4 The applications of nanorobots in the field of biomedicine
1.4.1 Microbiology
1.4.2 Cancer therapy using nanorobots
1.4.3 Biologically inspired nanorobots
1.4.4 The prospects of nanorobots for use in hematology
1.4.5 The neurosurgical prospects of nanorobots
1.5 The prospects of nanorobots for use in dentistry
1.6 The use of nanorobots in gene therapy
1.7 The biocompatibility and toxicity of nanorobots
1.8 Conclusions
References and further reading
Chapter Robotics and biophysics: technology advances and challenges in organic and inorganic domains
2.1 Introduction
2.2 An introduction to the use of robots in the field of biophysics
2.2.1 The importance of robots in the field of biophysical research
2.2.2 The possible application of robots in areas of biophysical investigation
2.2.3 Biophysical applications of robot-based systems
2.3 Technology advances of soft robotics in the organic domain
2.3.1 The applications of soft robots in medical and biological settings
2.3.2 Biomimetic design
2.3.3 The benefits of biomimetic design in biophysics
2.3.4 The challenges of applying biomimetic design principles in the field of biophysics
2.4 Developments in inorganic measurement technology
2.4.1 The integration of advanced prosthetic limbs and biophysics
2.4.2 Robotics in diagnostic imaging and laboratory tasks
2.5 Challenges in integration
2.5.1 Ethical and regulatory issues.
2.5.2 Regulatory challenges in the development of biophysics-based robotic systems
2.5.3 Interdisciplinary collaboration
2.6 Future prospects
2.7 Conclusions
References
Chapter Nanorobots: a primer for deciphering the biophysics of cancer
3.1 Introduction
3.2 Multiscale cancer biophysics
3.3 The biology of cancer cells
3.4 The reason for a biophysical strategy for cancer
3.5 Nanorobots
3.6 Nanorobots for the detection and treatment of cancer
3.7 Conclusions
References and further reading
Chapter The biophysics of cancer: management at the nanoscale
4.1 Introduction
4.2 Important aspects of nanorobots for cancer therapy
4.3 Nanorobot propulsion systems for anticancer medicine delivery
4.3.1 Nanorobots propelled by magnets
4.3.2 Nanorobots propelled by ultrasound
4.3.3 Biologically propelled nanorobots
4.3.4 Hybrid-drive nanorobots
4.3.5 Nanorobots propelled by other power sources
4.4 Precision cancer diagnosis and treatment with nanorobots
4.4.1 The identification and assessment of cancerous conditions
4.4.2 Gene therapy involving the precise administration of nucleic DNA
4.4.3 Vascular infarction in tumors
4.5 Nanorobots in cancer therapy: potential and clinical problems
4.5.1 The complexity and accuracy of the technology
4.5.2 Concerns regarding personal safety
4.5.3 Regulatory concerns
4.5.4 Scalability
4.5.5 Cost
4.5.6 Quality control
4.5.7 Management of the supply chain and its components
4.6 Future perspectives and conclusions
References
Chapter Magnetomechanical systems at the micro/nanoscale for cancer management
5.1 Introduction
5.2 Cancer therapy using magnetomechanical particles
5.2.1 Principle
5.3 The magnetomechanical identification of telomerase and nuclear acids in cancerous cells.
5.4 The therapeutic applications of telomerase studies in cancer
5.5 The clinical applications of telomeres and telomerase in oncology
5.6 Conclusions
Funding
Conflict of interest
References
Chapter The role of micro/nanorobotics in personalized healthcare
6.1 Introduction
6.2 Surgical operations
6.2.1 Biopsy and sample collection
6.2.2 The invasion or penetration of tissues
6.2.3 The breakdown of biofilms
6.2.4 Deliveries conducted within cells
6.3 Diagnosis
6.3.1 Biological sensors
6.3.2 Isolation
6.3.3 Physical sensors
6.4 Imaging and diagnostic medicine
6.4.1 Optical imaging
6.4.2 Imaging using ultrasound
6.4.3 Imaging using radionuclides
6.5 Prospective view
6.6 Regulatory challenges in personalized healthcare
6.7 Conclusions
References and further reading
Chapter The development of active nanorobots in personalized healthcare
7.1 Introduction
7.2 Nanorobots
7.3 Nanorobots in healthcare
7.3.1 Helices
7.3.2 Nanorods
7.3.3 DNA nanorobots
7.4 Applications of nanorobots in personalized healthcare
7.4.1 The use of nanorobots in dentistry
7.4.2 The use of nanorobots in cancer treatment
7.4.3 The application of nanorobots in the treatment and diagnosis of diabetes
7.4.4 The application of nanorobots in neurology
7.4.5 The application of nanorobots in hematology
7.5 Future perspectives
7.6 Conclusions
References
Chapter Nanozyme-based nanorobots for cancer treatment applications
8.1 Introduction
8.2 Nanomedicine and nanotheranostics
8.3 Targeted tumor vessel infarction with nanomedicine
8.4 Targeted tumor drug delivery systems
8.4.1 Passively targeted drug delivery systems
8.4.2 Actively targeted medication delivery systems
8.5 Micro- and nanorobots
8.5.1 Chemically powered micro- and nanorobots.
8.5.2 External-field-powered micro- and nanorobots
8.5.3 Biohybrid micro- and nanorobots
8.6 Difficulties with cancer nanomedicines
8.7 Future perspectives
8.8 Conclusions
References
Chapter Progress in the bioelectrochemical and biophysical diagnostic profiling of malignant cancer cells
9.1 Introduction
9.2 The use of biosensors in clinical assessment
9.3 Electrochemical biosensors
9.3.1 Various electrochemical measurement methods
9.4 Conventional apoptotic and metastatic cell detection methods
9.5 Bioelectricity in cancer processes
9.5.1 Cancer and ion channels
9.5.2 Calcium channels
9.5.3 Sodium channels
9.5.4 Intracellular potassium channels
9.5.5 Chloride channels
9.5.6 Piezoelectric channels
9.6 The detection of bioelectric characteristics
9.7 Bioelectrical modifications
9.8 Electrification and extracellular vesicles
9.9 Biosensors for in vitro cancer cell assessment
9.10 Conclusions
References and further reading
Chapter Wireless microrobots: the next frontier in medical advancements
10.1 Introduction
10.2 Microrobots and their potential therapeutic applications
10.2.1 The imaging of functional capabilities for disorder diagnosis
10.2.2 Mobile situational awareness for disease diagnosis and health management
10.3 Targeted therapy
10.4 The applications of microrobotics in medicine, particularly in the human cardiovascular system and the bloodstream
10.5 Biomechanical restrictions that impede microrobots
10.6 Current challenges facing miniaturized biomedical robots and their potential future applications
10.7 Methods for the actuation and control of therapeutic microrobots
10.8 Conclusions
References and further reading
Chapter Revolutionizing cancer treatment using micro/nanorobotic devices
11.1 Introduction.
11.2 Nano/microrobots for drug delivery
11.3 Cancer-targeted drug delivery systems
11.3.1 Enhancing treatment precision using passive drug delivery
11.3.2 Enhancing treatment precision using active drug targeting
11.3.3 Surgical advancements with micro/nanorobotic assistance
11.3.4 Robotic biosensing
11.3.5 Enhancing drug delivery with micro/nanorobot mobility
11.3.6 Field-guided micro/nanorobotics
11.4 Conclusions and prospects
References and further reading
Chapter Cyborgs and cyberorgans: biosecurity in biorobotics for healthcare-a case study
12.1 Introduction
12.2 Biorobotics in healthcare
12.3 Cyborgs and cyberorgans in healthcare
12.4 Case study
12.5 Patent list
12.6 Conclusions
References.