The calculation of genetic risks : worked examples in DNA diagnostics / Peter J. Bridge.

General introduction to the estimation of genetic risks
Mendelian risk
Risk modified by reproductive history
Risk based upon phenotype
Risk based upon genotype
Familial versus new mutations
Meiotic versus mitotic mutations
Non-Mendelian genetic mechanisms
Bayesian risk calculations for X-linked recessive disorders
Unaffected sons
Daughters with unaffected grandsons
Which branches of the family may be used?
Negative family history
Incorporation of females with biochemical test results into bayesian calculations
Linearity of the test results
Column ratios
Biochemical tests on the consultand herself
Stating conditional probabilities in words
Resolution of conflicting evidence
Noncarrier ratios
Negative family history
Pedigree risks in autosomal conditions
Autosomal dominant inheritance
Autosomal recessive inheritance
Introduction to DNA polymorphisms
Statistical approaches to gene mapping
Iod scores
Probabilities over pedigrees
Multipoint linkage analysis.

(cont) Use of DNA polymorphisms in predicting genetic risks
Single markers in familial cases
Flanking markers in familial cases
Single markers and potentially new mutations
Flanking markers and potentially new mutations
Direct detection of mutations
Uniparental disomy
Genetic heterogeneity
Linkage disequilibrium and haplotype analysis
When do mutations occur?
Integration of RFLP data with non-DNA parameters
Biochemical test results
Incomplete penetrance and age-at-onset corrections
Decoding lod scores
Pascal's triangle and the binomial expansion
Program to generate phase values for flanking markers and reduced penetrance or delayed age at onset.