Chronic fatigue: definition and history
Definition of chronic fatigue
History of chronic fatiguing illnesses
Definition of chronic fatigue syndrome and cancer-related fatigue
Factors that influence the diagnosis and treatment of fatigue and chronic fatiguing illnesses
Measurement of fatigue perception and severity
Relevance of fatigue to other symptoms, and to diagnosis, predisposition, and treatment of illnesses such as cancer
Relevance of fatigue to symptom distress and quality of life
Relevance of fatigue in the diagnosis of other diseases such as cancer
Relevance of fatigue and chronic fatiguing illnesses in predisposition to diseases such as cancer
Relevance of fatigue in the treatment of other disease such as cancer


Possible causative, predisposing, and perpetuating factors of chronic fatiguing illnesses
Body defense factors (immunological factors)
Endocrine factors
Neurological factors
Psychological and psychiatric factors
Hematological factors
Musculoskeletal factors
Nutritional factors
Treatment of chronic fatiguing illnesses
Graded exercise
Graded activity (energy management) therapy
Sleep therapy
Cognitive behavioral therapy
Nutritional therapy
Pharmacological therapy
Complementary and alternative therapy
Immunotherapy
Antimicrobial therapies.