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Approaches used by others and existing safety frameworks
The framework
Categories of scientific evidence
human information and data
Categories of scientific evidence
animal data
Categories of scientific evidence
information about related substances
Categories of scientific evidence
in vitro data
Interactions
Vulnerable groups and prevalence of use
Scientific principles for integrating and evaluating the available data
Applying the framework: case studies using the prototype safety monographs
Factors influencing use of the safety framework
Findings and recommendations.

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