Introduction and historical overview / Kenneth B. Stoller and George E. Bigelow
Regulatory, cost, and policy issues / Kenneth B. Stoller and George E. Bigelow
Epidemiology of opioid use, abuse, and dependence / Rosa M. Crum
Pharmacology of methadone / Sharon L. Walsh and Eric C. Strain
Beginning and ending methadone dosing: induction and withdrawal / Eric C. Strain
Methadone dose during maintenance treatment / Eric C. Strain
Counseling and psychosocial services / Michael Kidorf, Van L. King, and Robert K. Brooner
Contingency management therapies / Maxine L. Stitzer, Nancy Petry, and Kenneth Silverman
Practical issues of program organization and operation / Mary Bailes and Connie Lowery
Pharmacology of buprenorphine / Eric C. Strain
Clinical use of buprenorphine / Eric C. Strain
Office-based treatment with buprenorphine and other medications / David Fiellin and Eric C. Strain
Pharmacology and clinical use of LAAM, clonidine, and lofexidine / Eric C. Strain


Pharmacology and clinical use of naltrexone / Maria A. Sullivan, Sandra D. Comer, and Edward V. Nunes
Medication-free treatment of opioid dependence / George De Leon, Hendrée E. Jones, and Maxine L. Stitzer
Medically supervised withdrawal as stand-alone treatment / Michael Gossop
Other substance use disorders in the treatment of opioid dependence: prevalence, consequences, detection, and management / Maxine L. Stitzer and Stacey C. Sigmon
Co-morbid medical disorders / Michael I. Fingerhood
Co-morbid psychiatric disorders / Van L. King, Jessica Peirce, and Robert K. Brooner
Specialty treatment for women / Hendrée E. Jones ... [et al.]
Treatment of persons under legal restrictions / Carl G. Leukefeld ... [et al.]
Treatment of adolescents / Lisa A. Marsch
Prescription opioid nonmedical use and abuse / James P. Zacny
Pain management in addicted patients / Mitchell J.M. Cohen and Samar A. Jasser.