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What qualifies as evidence of effective practice?
What qualifies as research on which to judge effective practice?
Does manualization improve therapy outcomes?
Are research patients and clinical trials representative of clinical practice?
What should be validated?
What else materially influences what is represented and published as evidence?
Do therapies designated as ESTs for specific disorders produce outcomes superior to non-EST therapies?
How well do both evidence-based practices and TAU satisfactorily address the various dimensions of diversity?
Are efficacious laboratory-validated treatments readily transportable to clinical practice?

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