000386045 000__ 02295cam\a2200373\a\4500 000386045 001__ 386045 000386045 005__ 20210513135041.0 000386045 006__ m\\\\\\\\u\\\\\\\\ 000386045 007__ cr\cn||||||||| 000386045 008__ 080709s2008\\\\dcua\\\\sb\\\\000\0\eng\d 000386045 010__ $$z 2008299448 000386045 020__ $$z9780309116688 000386045 020__ $$z0309116686 000386045 035__ $$a(CaPaEBR)ebr10235163 000386045 035__ $$a(OCoLC)646754057 000386045 040__ $$aCaPaEBR$$cCaPaEBR 000386045 043__ $$an-us--- 000386045 05014 $$aRC270.8$$b.I47 2008eb 000386045 08204 $$a362.196/994007$$222 000386045 24500 $$aImproving the quality of cancer clinical trials$$h[electronic resource] :$$bworkshop summary /$$cNational Cancer Policy Forum, Margie Patlack and Sharyl Nass, rapporteurs. 000386045 260__ $$aWashington, D.C. :$$bNational Academies Press,$$cc2008. 000386045 300__ $$axii, 124 p. :$$bill. (some col.) ;$$c23 cm. 000386045 504__ $$aIncludes bibliographical references. 000386045 5050_ $$aIntroduction -- New clinical trial designs. Phase 0 trials -- Adaptive trial designs -- Targeting multiple pathways with multiple drugs -- Preclinical model systems -- Molecular imaging. Current and developing methods -- Challenges of molecular imaging -- Screening for predictive markers. The challenges of clinical validation -- Bioimaging predictive markers -- Clinical translation -- Panel discussion -- Costs of clinical trials. Regulatory costs -- Patient accrual -- Global outsourcing -- Time is money -- Public-private collaborations -- Regulatory issues. Regulatory barriers to innovation -- Patient advocacy perspective -- Regulation of in vitro diagnostics -- Regulatory issues in improving cancer clinical trials -- Reports from the case study discussion groups. Adaptive trial design -- Phase 0 trials -- Imaging -- Use of proteomics/genomics to assign therapy in lung cancer -- Use of genetics/genomics to assign therapy. 000386045 506__ $$aAccess limited to authorized users. 000386045 530__ $$aAlso available on the World Wide Web. 000386045 650_0 $$aCancer$$xTreatment$$zUnited States. 000386045 650_0 $$aClinical trials. 000386045 655_7 $$aElectronic books.$$2lcsh 000386045 7001_ $$aPatlak, Margie. 000386045 7001_ $$aNass, Sharyl J. 000386045 85280 $$bebk$$hProquest Ebook Central Academic Complete 000386045 85640 $$3ProQuest Ebook Central Academic Complete$$uhttps://univsouthin.idm.oclc.org/login?url=http://site.ebrary.com/lib/usiricelib/Doc?id=10235163$$zOnline Access 000386045 909CO $$ooai:library.usi.edu:386045$$pGLOBAL_SET 000386045 980__ $$aEBOOK 000386045 980__ $$aBIB 000386045 982__ $$aEbook 000386045 983__ $$aOnline