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1. Introduction (basic science, systems and analysis, manufacturing)
2. Grand challenges (threat reduction, preparation, situational awareness, threat neutralization and remediation)
3. Specific challenges (threat reduction, preparation-medical countermeasures, interdisciplinary and multidisciplinary research, situational awareness, threat neutralization and remediation)
4. Research directions (threat reduction, preparation, situational awareness, threat neutralization and remediation).

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