Historical perspective
Gene transfer with plasmid biopharmaceuticals
Product and process development
Structure
Analytical characterization
Delivery
Ethical and safety issues
Human and veterinary markets
Human case studies : pandemic influenza and critical limb ischaemia
Veterinary case studies : West Nile, infectious hematopoietic necrosis, and melanoma
GMPS and validation
Product specifications and quality control
Cell culture
An overview of downstream processing
Primary isolation
Intermediate recovery
Final purification
Process synthesis
Concluding remarks and outlook.