000461790 000__ 02398cam\a2200349\a\4500 000461790 001__ 461790 000461790 005__ 20210513161834.0 000461790 006__ m\\\\\\\\d\\\\\\\\ 000461790 007__ cr\cn||||||||| 000461790 008__ 110620s2012\\\\njuaf\\\sb\\\\000\0\eng\d 000461790 010__ $$z 2011026192 000461790 020__ $$z9780470497180 (cloth) 000461790 020__ $$z9781118150542 (e-book) 000461790 035__ $$a(CaPaEBR)ebr10521349 000461790 035__ $$a(OCoLC)778431548 000461790 040__ $$aCaPaEBR$$cCaPaEBR 000461790 05014 $$aRS403$$b.A53 2012eb 000461790 08204 $$a615.1/9$$223 000461790 24500 $$aAnalysis of aggregates and particles in protein pharmaceuticals$$h[electronic resource] /$$cedited by Hanns-Christian Mahler, Wim Jiskoot. 000461790 260__ $$aHoboken, N.J. :$$bJohn Wiley & Sons, Inc.,$$c2012. 000461790 300__ $$axvi, 443 p., [12] p. of plates :$$bill. (some col.) 000461790 504__ $$aIncludes bibliographical references. 000461790 5050_ $$aThe critical need for robust assays for quantitation and characterization of aggregates of therapeutic proteins -- Separation based analytical methods for measuring protein aggregation -- Laser light scattering-based techniques used for the characterization of protein therapeutics -- Online detection methods and emerging techniques for soluble aggregates in protein pharmaceuticals -- Analytical methods to measure sub-visible particulates -- Detection of visible particles in parenteral products -- Characterization of aggregates and particles using emerging techniques -- Ultraviolet absorption spectroscopy -- Fluorescence spectroscopy to characterize protein aggregates and particles -- Infrared spectroscopy to characterize protein aggregates -- Raman microscopy for characterization of particles -- Microscopic methods for particle characterization in protein pharmaceuticals -- Comparison of methods for soluble aggregate detection and size characterization -- Protein purification and its relation to protein aggregation and particles -- Formulation development and its relation to protein aggregation and particles. 000461790 506__ $$aAccess limited to authorized users. 000461790 650_0 $$aPharmaceutical chemistry. 000461790 650_0 $$aProtein drugs$$xAnalysis. 000461790 655_7 $$aElectronic books.$$2lcsh 000461790 7001_ $$aMahler, Hanns-Christian. 000461790 7001_ $$aJiskoot, Wim. 000461790 852__ $$bebk 000461790 85640 $$3ProQuest Ebook Central Academic Complete$$uhttps://univsouthin.idm.oclc.org/login?url=http://site.ebrary.com/lib/usiricelib/Doc?id=10521349$$zOnline Access 000461790 909CO $$ooai:library.usi.edu:461790$$pGLOBAL_SET 000461790 980__ $$aEBOOK 000461790 980__ $$aBIB 000461790 982__ $$aEbook 000461790 983__ $$aOnline