000462170 000__ 01991cam\a2200337\a\4500 000462170 001__ 462170 000462170 005__ 20210513161942.0 000462170 006__ m\\\\\\\\d\\\\\\\\ 000462170 007__ cr\cn||||||||| 000462170 008__ 110510s2011\\\\njua\\\\sb\\\\001\0\eng\d 000462170 010__ $$z 2011019939 000462170 020__ $$z9780470484067 (cloth) 000462170 020__ $$z9781118140383 (e-book) 000462170 035__ $$a(CaPaEBR)ebr10558150 000462170 035__ $$a(OCoLC)794619804 000462170 040__ $$aCaPaEBR$$cCaPaEBR 000462170 05014 $$aRM301.5$$b.P48 2011eb 000462170 08204 $$a615/.7$$223 000462170 1001_ $$aPeters, Sheila Annie. 000462170 24510 $$aPhysiologically-based pharmacokinetic (PBPK) modeling and simulations$$h[electronic resource] :$$bprinciples, methods, and applications in the pharmaceutical industry /$$cSheila Annie Peters. 000462170 260__ $$aHoboken, N.J. :$$bWiley,$$cc2011. 000462170 300__ $$axvii, 430 p. :$$bill. 000462170 504__ $$aIncludes bibliographical references and index. 000462170 5050_ $$aModelling in the pharmaceutical industry -- Physiologically-based modelling -- A review of pharmacokinetic principles -- Physiological model for absorption -- Physiological model for distribution -- Physiological models for drug metabolism and excretion -- Generic whole-body physiologically-based pharmacokinetic modelling -- Variability, uncertainty and sensitivity analysis -- Evaluation of drug-drug interaction risk with pbpk models -- PBPK of biotherapeutics -- Data integration and sensitivity analysis -- Hypothesis generation and pharmacokinetic predictions -- Integration of PBPK and pharmacodynamics -- PBPK modelling of populations -- PBPK models along the drug discovery and development value chain. 000462170 506__ $$aAccess limited to authorized users. 000462170 650_0 $$aPharmacokinetics$$xMathematical models. 000462170 650_0 $$aDrugs$$xDesign$$xMathematical models. 000462170 655_7 $$aElectronic books.$$2lcsh 000462170 852__ $$bebk 000462170 85640 $$3ProQuest Ebook Central Academic Complete$$uhttps://univsouthin.idm.oclc.org/login?url=http://site.ebrary.com/lib/usiricelib/Doc?id=10558150$$zOnline Access 000462170 909CO $$ooai:library.usi.edu:462170$$pGLOBAL_SET 000462170 980__ $$aEBOOK 000462170 980__ $$aBIB 000462170 982__ $$aEbook 000462170 983__ $$aOnline