Title
High-throughput screening methods in toxicity testing [electronic resource] / edited by Pablo Steinberg.
ISBN
9781118065631 (hardback)
9781118538180 (e-book)
Imprint
Hoboken, N.J. : Wiley, 2013.
Language
English
Description
xv, 552 p., [16] p. of plates : ill. (some col.)
Call Number
RS419.5 .H542 2013eb
Dewey Decimal Classification
615.1/9
Summary
"High-throughput assays are part of a paradigm shift, to more cost-effective and reliable methods, in the testing of chemical and drug safety. This book covers methods, data generation, data analysis, and applications in risk assessment for major toxicological assays to help toxicologists apply and understand the benefits and limits of high-throughput testing assays. Each chapter describes method principles and includes detailed information on data generation, data analysis, and applications in risk assessment. The topic is especially timely given Europe's REACH legislation and the US National Research Council"-- Provided by publisher.
Bibliography, etc. Note
Includes bibliographical references and index.
Access Note
Access limited to authorized users.
pt. 1. General aspects
pt. 2. High-throughput assays to assess different cytotoxicity endpoints
pt. 3. High-throughput assays to assess DNA damage and carcinogenesis
pt. 4. High-throughput assays to assess reproductive toxicity, cardiotoxicity, and haematotoxicity
pt. 5. High-throughput assays to assess drug metabolism and receptor-related toxicity.
